Codeine induced respiratory depression in a child [3]

Paediatric Anaesthesia

Volumn 18, Issue 3, 2008, Pages 272-273

  Stamer, Ulrike M ^a   Stüber, Frank ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CODEINE; CYTOCHROME P450 2D6; O NORTRAMADOL; TRAMADOL;

ALLELE; CAUCASIAN; COUGHING; GENE DUPLICATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; RESPIRATION DEPRESSION;

ANTITUSSIVE AGENTS; CHILD, PRESCHOOL; CODEINE; CYTOCHROME P-450 CYP2D6; ETHNIC GROUPS; HUMANS; RESPIRATORY INSUFFICIENCY;

EID: 38549165713     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2008.02415.x     Document Type: Letter

References (6)

1. Voronov P, Przybylo HJ, Jagannathan N. Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer. Paediatr Anaesth 2007 17 : 684 687.
2. Kirchheiner J, Schmidt H, Tzvetkov M et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J 2007 7 : 257 265.
3. Stamer UM, Mußhoff F, Kobilay M et al. Concentrations of tramadol and O-demethyltramadol in different CYP2D6 genotypes. Clin Pharmacol Ther 2007 82 : 41 47.
4. Williams DG, Patel A, Howard RF. Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. Br J Anaesth 2002 89 : 839 845.
5. Gasche Y, Daali Y, Fathi M et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 2004 351 : 2827 2831.
6. Koren G, Cairns J, Chitayat D et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006 368 : 704.