Combining host modulation and topical antimicrobial therapy in the management of moderate to severe periodontitis: A randomized multicenter trial

Journal of Periodontology

Volumn 79, Issue 1, 2008, Pages 33-41

  John Novak, M ^a   Dawson III, Dolphus R ^a   Magnusson, Ingvar ^b   Karpinia, Katherine ^b   Poison, Alan ^c   Polson, Anne ^c   Ryan, Maria E ^d   Ciancio, Sebastian ^e   Drisko, Connie H ^f   Kinane, Denis ^g   Powala, Christopher ^h   Bradshaw, Mark ^a,i  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

^f MEDICAL COLLEGE OF GEORGIA   (United States)

^g UNIVERSITY OF LOUISVILLE   (United States)

^h Managed Care and Professional Affairs   (United States)

ⁱ Global Consulting Partners in Medical Biometrics   (United States)

Author keywords

Clinical trial; Periodontitis; Root planing; Therapy

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GINGIVA BLEEDING; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; ORAL DRUG ADMINISTRATION; PERIODONTAL DISEASE; PERIODONTICS; PERIODONTITIS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; COMBINED MODALITY THERAPY; DENTAL SCALING; DOXYCYCLINE; FEMALE; FOLLOW-UP STUDIES; GINGIVAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PLACEBOS; ROOT PLANING; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 38549164354     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.070237     Document Type: Article

References (19)

1. Page RC, Kornman KS. The pathogenesis of human periodontitis: An introduction. Periodontol 2000 1997; 14:9-11.
2. Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000 2001;25:77-88.
3. Hallmon WW, Rees TD. Local anti-infective therapy: Mechanical and physical approaches. A systematic review. Ann Periodontol 2003;8:99-113.
4. Hanes PJ, Purvis JP. Local anti-infective therapy: Pharmacological agents. A systematic review. Ann Periodontol 2003;8:79-94.
5. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective therapy. A systematic review. Ann Periodontol 2003;8:115-179.
6. Golub LM, Ciancio S, Ramamurthy NS, Leung M, McNamara TF. Low-dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans. J Periodontal Res 1990;25:321-330.
7. Golub LM, Sorsa T, Lee HM, et al. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 1995;22:100-109.
8. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. A systematic review. Ann Periodontol 2003;8:12-34.
9. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odont Scand 1963;21: 533-551.
10. American Academy of Periodontology. Parameter on chronic periodontitis with slight to moderate loss of periodontal support. J Periodontol 2000;71(5 Suppl.): 853-858.
11. Cobb CM. Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996;1:443-490.
12. Lamster I, Novak MJ. Host mediators in gingival crevicular fluid: Implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med 1992;3: 31-60.
13. Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000 2001;25:8-20.
14. Wennstrom JL, Newman HN, MacNeill SR, et al. Utilization of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-center trial of 2 treatment approaches. J Clin Periodontol 2001;28: 753-761.
15. Caton JQ, Ciancio SG, Blieden TM, et al. Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol 2000;71: 521-532.
16. Preshaw PM, Hefti AF, Novak MJ, et al. Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: A multicenter trial. J Periodontol 2004;75:1068-1076.
17. American Academy of Periodontology. Modulation of the host response in periodontal therapy (informational paper). J Periodontol 2002;73:460-470.
18. Walker CB, Godowski KC, Borden L, et al. The effects of sustained release doxycycline on the anaerobic flora and antibiotic-resistant patterns in subgingival plaque and saliva. J Periodontol 2000;71:768-774.
19. Stoller NH, Johnson LR, Trapnell S, Harrold CQ, Garrett S. The pharmacokinetic profile of a biodegradable controlled-release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. J Periodontol 1998;69:1085-1091.