The limited efficacy of tramadol in postoperative patients: A study of ED80 using the continual reassessment method

Anesthesia and Analgesia

Volumn 106, Issue 2, 2008, Pages 622-627

  Thévenin, Aude ^a   Beloeil, Hélène ^a   Blanie, Antonia ^a   Benhamou, Dan ^a   Mazoit, Jean Xavier ^a,b  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; TRAMADOL;

ADULT; ANTINOCICEPTION; ARTICLE; CARDIOPULMONARY HEMODYNAMICS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; FEMALE; HUMAN; MALE; NAUSEA; OPERATION DURATION; PAIN ASSESSMENT; PAIN THRESHOLD; PATIENT ASSESSMENT; POSTANESTHESIA CARE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROBABILITY; PRURITUS; RECOVERY ROOM; RESPIRATION DEPRESSION; SEDATION; SEIZURE; SIDE EFFECT; SURGICAL PATIENT; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; VOMITING; XEROSTOMIA;

EID: 38549156031     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31816053aa     Document Type: Review

References (22)

1. Lee CR, McTavish D, Sorkin EM. Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs 1993;46:313-40
2. Grond S, Meuser T, Zech D, Hennig U, Lehmann KA. Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient-controlled analgesia. Pain 1995;62:313-20
3. Houmes RJ, Voets MA, Verkaaik A, Erdmann W, Lachmann B. Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain with special regard to respiratory depression. Anesth Analg 1992;74:510-4
4. Babul N, Noveck R, Chipman H, Roth SH, Gana T, Albert K. Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee. J Pain Symptom Manage 2004;28:59-71
5. Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 2000;60:139-76
6. Marcou TA, Marque S, Mazoit JX, Benhamou D. The median effective dose of tramadol and morphine for postoperative patients: a study of interactions. Anesth Analg 2005;100:469-74
7. Paul M, Fisher DM. Are estimates of MAC reliable? Anesthesiology 2001;95:1362-70
8. Lu W, Ramsay JG, Bailey JM. Reliability of pharmacodynamic analysis by logistic regression: mixed-effects modeling. Anesthesiology 2003;99:1255-62
9. O'Quigley J, Pepe M, Fisher L. Continual reassessment method: a practical design for phase 1 clinical trials in cancer. Biometrics 1990;46:33-48
10. Beloeil H, Eurin M, Thevenin A, Benhamou D, Mazoit JX. Effective dose of nefopam in 80% of patients (ED80): a study using the Continual Reassessment Method. Br J Pharmacol 2007;64:686-93
11. Zohar S, Latouche A, Taconnet M, Chevret S. Software to compute and conduct sequential Bayesian phase I or II doseranging clinical trials with stopping rules. Comput Methods Programs Biomed 2003;72:117-25
12. Venables W, Ripley B. Modern applied statistics with S-Plus. Statistics and computing series. 3rd ed. New York: Springer-Verlag, 1999
13. Fabre E, Chevret S, Piechaud JF, Rey E, Vauzelle-Kervoedan F, D'Athis P, Olive G, Pons G. An approach for dose finding of drugs in infants: sedation by midazolam studied using the continual reassessment method. Br J Clin Pharmacol 1998;46:395-401
14. Lehmann KA, Kratzenberg U, Schroeder-Bark B, Horrichs-Haermeyer G. Postoperative patient-controlled analgesia with tramadol: analgesic efficacy and minimum effective concentrations. Clin J Pain 1990;6:212-20
15. Silvasti M, Svartling N, Pitkanen M, Rosenberg PH. Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. Eur J Anaesthesiol 2000;17:448-55
16. Dougherty TB, Porche VH, Thall PF. Maximum tolerated dose of nalmefene in patients receiving epidural fentanyl and dilute bupivacaine for postoperative analgesia. Anesthesiology 2000;92:1010-6
17. Desfrere L, Zohar S, Morville P, Brunhes A, Chevret S, Pons G, Morietet G, Rey E, Treluyer JM. Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method. J Clin Pharm Ther 2005;30:121-32
18. Gana TJ, Pascual ML, Fleming RR, Schein JR, Janagap CC, Xiang J, Vorsanger GJ. Extended-release tramadol in the treatment of osteoarthritis: a multicenter, randomized, double-blind, placebo-controlled clinical trial. Curr Med Res Opin 2006;22:1391-401
19. Webb AR, Leong S, Myles PS, Burn SJ. The addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trial. Anesth Analg 2002;95:1713-8
20. Stiller CO, Lundblad H, Weidenhielm L, Tulberg T, Grantinger B, Lafolie P, Jansson KA. The addition of tramadol to morphine via patient-controlled analgesia does not lead to better postoperative pain relief after total knee arthroplasty. Acta Anaesthesiol Scand 2007;51:322-30
21. Torres LM, Rodriguez MJ, Montero A, Herrera J, Calderon E, Cabrera J, Porres R, de la Torre MR, Martinez T, Gomez JL, Ruiz J, Garcia-Magaz I, Camara J, Ortiz P. Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: a randomized, double-blind, multicenter study. Reg Anesth Pain Med 2001;26:118-24
22. O'Quigley J, Chevret S. Methods for dose finding studies in cancer clinical trials: a review and results of a Monte Carlo study. Stat Med 1991;10:1647-64