The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy

Anesthesia and Analgesia

Volumn 106, Issue 2, 2008, Pages 650-653

  Liu, Jian ^a,b   Li, Weiyan ^a   Zhu, Juan ^a   Zhang, Jing ^a   Feng, Xiaomei ^a   Guan, Ren ^a   Xu, Jianguo ^a  

^a NANJING UNIVERSITY   (China)

^b NONE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PENTOXIFYLLINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; GLIA CELL; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; MECHANICAL STIMULATION; NERVE TRANSECTION; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL NERVE;

EID: 38549142555     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31815efaba     Document Type: Article

References (16)

1. Moalem G, Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Brain Res Rev 2006;51:240-64
2. Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallel the development of allodynic behavior. Glia 1998;23:75-83
3. Winkelstein BA, Rutkowski MD, Sweitzer SM, Pahl JL, DeLeo JA. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol 2001;439:127-39
4. Tanga FY, Nutile-McMenemy N, DeLeo JA. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci USA 2005;102:5856-61
5. Chao CC, Hu S, Ehrlich L, Peterson PK. Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immunol 1995;9:355-65
6. Serou MJ, DeCoster MA, Bazan NG. Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. J Neurosci Res 1999;58:593-8
7. Inoue A, Ikoma K, Morioka N, Kumagai K, Hashimoto T, Hide I, Nakata Y. Interleukin-1 beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system. J Neurochem 1999;73:2206-13
8. Liu J, Feng X, Yu M, Xie W, Zhao X, Li W, Guan R, Xu J. Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain. Neurosci Lett 2007;412:268-72
9. Colburn RW, Rickman AJ, DeLeo JA. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol 1999;157:289-304
10. Vale ML, Benevides VM, Sachs D, Brito GA, da Rocha FA, Poole S, Ferreira SH, Cunha FQ, Ribeiro RA. Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol 2004;143:833-44
11. Ding M, Hart RP, Jonakait FM. Tumor necrosis factor-α induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. J Neurobiol 1995;28:445-54
12. Jeanjean AP, Moussaoui SM, Maloteaux JM, Laduron PM. Interleukin-1β induces long term increase of axonally transported opiate receptors and substance P. Neuroscience 1995;68:151-7
13. Tonai T, Taketani Y, Ueda N, Nishisho T, Ohmoto Y, Sakata Y, Muraguchi M, Wada K, Yamamoto S. Possible involvement of interleukin-1β in cyclooxygenase-2 induction after spinal cord injury in rats. J Neurochem 1999;72:302-9
14. Sweitzer SM, Schubert P, DeLeo JA. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 2001;297:1210-17
15. Tawfik VL, Nutile-McMenemy N, Lacroix-Fralish ML, Deleo JA. Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. Brain Behav Immun 2007;21:238-46
16. Dorazil-Dudzik M, Mika J, Schafer MK, Li Y, Obara I, Wordliczek J, Przewlocka B. The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw. Anesth Analg 2004;98:1566-73