E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer

Head and Neck

Volumn 30, Issue 1, 2008, Pages 85-92

  De Moraes, Renato Vieira ^a   Oliveira, Denise Tostes ^a   Landman, Gilles ^a   De Carvalho, Fabrício ^a   Caballero, Otávia ^a   Nonogaki, Suely ^a   Nishimoto, Inês ^a   Kowalski, Luis Paulo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

E cadherin; Methylation; Oral cancer; Squamous cell carcinoma; Verrucous carcinoma

Indexed keywords

UVOMORULIN;

ADULT; ARTICLE; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; E CADHERIN GENE; FEMALE; GENE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MOUTH CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; VERRUCOUS CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, SQUAMOUS CELL; CARCINOMA, VERRUCOUS; CPG ISLANDS; DNA METHYLATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; POLYMERASE CHAIN REACTION;

EID: 38549124453     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.20666     Document Type: Article

References (21)

1. Christofori G, Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999;24:73-76.
2. Hajra KM, Fearon ER. Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer 2002;34: 255-268.
3. Mattijssen V, Peters HM, Schalkwijk L, et al. E-cadherin expression in head and neck squamous cell carcinoma is associated with clinical outcome. Int J Cancer 1993;55:580-585.
4. Ziober BL, Silverman SS, Kramer RH. Adhesive mechanisms regulating invasion and metastasis in oral cancer. Crit Rev Oral Biol Med 2001;12:499-510.
5. Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 2000;275:2727-2732.
6. Kudo Y, Kitajima S, Ogawa I, et al. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous β-catenin. Clin Cancer Res 2004;10:5455-5463.
7. Chang HW, Chow V, Lam KY, Wei WI, Yuen A. Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002;94:386-392.
8. Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun 2004;315: 850-8566.
9. Nakayama S, Sasaki A, Mese H, Alcalde RE, Tsuji T, Matsumura T. The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Int J Cancer 2001;93:667-673.
10. Viswanathan M, Tsuchida N, Shanmugam G. Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. Int J Cancer 2003;105:41-46.
11. Yeh KT, Shih MC, Lin TH, et al. The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma. Anticancer Res 2002;22:3971-3975.
12. Goldenberg D, Harden S, Masayesva BG, et al. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg 2004;130:39-44.
13. Zöchbauer-Müller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. Aberrant promoter methylation of the multiple genes in non-small cell lung cancer. Cancer Res 2001;61:249-255.
14. Hirohashi S, Kanai Y. Cell adhesion system and human cancer morphogenesis. Cancer Sci 2003;94:575-581.
15. Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK. J Cell Biol 2003;163: 847-857.
16. Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT. Patterns of gene promoter methylation in squamous cell cancer of the head and neck. Oncogene 2002;21: 4231-4236.
17. Slaus NP. Tumor suppressor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int 2003;3:17-23.
18. Tang ZG, Zou P, Xie XL. Expression of E-cadherin gene protein in oral verrucous carcinoma. Hunan Yi Ke Da Xue Xue Bao 2003;28:206-208.
19. Tian Z, Guo W, Zhang WG. The expression of E-cadherin in oral cancer with different biological behavior. Shanghai Kou Qiang Yi Xue 2002;11:350-352.
20. Chow V, Yuen AP, Lam KY, Tsao GS, Ho WK, Wei WI. A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol 2001;127:59-63.
21. Koch BB, Trask DK, Hoffman HT, et al. National survey of head and neck verrucous carcinoma. Cancer 2001;92: 110-120.