The periodontitis and vascular events (PAVE) pilot study: Recruitment, retention, and community care controls

Journal of Periodontology

Volumn 79, Issue 1, 2008, Pages 80-89

  Couper, David J ^a   Beck, James D ^b   Falkner, Karen L ^c   Graham, Susan P ^c   Grossi, Sara G ^d   Gunsolley, John C ^e   Madden, Theresa ^f,g   Maupome, Gerardo ^h   Offenbacher, Steven ^b   Stewart, Dawn D ^a   Trevisan, Maurizio ^c   Van Dyke, Thomas E ⁱ   Genco, Robert J ^c  

^a IL   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d EAST CAROLINA UNIVERSITY   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g AUCKLAND UNIVERSITY OF TECHNOLOGY   (New Zealand)

^h INDIANA UNIVERSITY   (United States)

ⁱ BOSTON UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Controlled clinical trial; Periodontal disease; Pilot study; Subgingival scaling

Indexed keywords

AGED; ARTICLE; CLINICAL TRIAL; COMMUNITY CARE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DENTAL CARE; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; MOUTH HYGIENE; MULTICENTER STUDY; PATIENT COMPLIANCE; PATIENT SELECTION; PERIODONTITIS; PILOT STUDY; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SAMPLE SIZE; SMOKING; TREATMENT OUTCOME;

AGED; COMMUNITY HEALTH SERVICES; CONTROL GROUPS; CORONARY ARTERY DISEASE; DENTAL CARE; DENTAL SCALING; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; ORAL HYGIENE; PATIENT COMPLIANCE; PATIENT SELECTION; PERIODONTITIS; PILOT PROJECTS; RESEARCH DESIGN; RISK FACTORS; ROOT PLANING; SAMPLE SIZE; SMOKING; TREATMENT OUTCOME;

EID: 38549121965     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.070216     Document Type: Article

References (55)

1. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003;8:38-53.
2. Janket SJ, Baird AE, Chuang SK, Jones JA. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:559-569.
3. Khader YS, Albashaireh ZS, Alomari MA. Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: A meta-analysis. J Periodontol 2004; 75:1046-1053.
4. Dietrich T, Garcia RI. Associations between periodontal disease and systemic disease: Evaluating the strength of the evidence. J Periodontol 2005;76(11 Suppl.):2175-2184.
5. Beck JD, Offenbacher S. Systemic effect of periodontitits: Epidemiology of periodontal disease and cardiovascular disease. J Periodontol 2005;76(11 Suppl.): 2089-2100.
6. Loesche WJ, Schork A, Terpenning MS, Chen Y-M, Kerr C, Dominguez BL. The relationship between dental disease and cerebral vascular accident in elderly united States veterans. Ann Periodontol 1998;3:161-174.
7. Mattila K, Nieminen MS, Valtonen V, et al. Association between dental health and acute myocardial infarction. BMJ 1989;298:779-781.
8. Nakib SA, Pankow JS, Beck JD, et al. Periodontitis and coronary artery calcification: The Atherosclerosis Risk in Communities (ARIC) study. J Periodontol 2004; 75:505-510.
9. Paunio K, Impivaara O, Tiekso J, Maki J. Missing teeth and ischaemic heart disease in men aged 45-64 years. Eur Heart J 1993;14(Suppl. K):54-56.
10. Pussinen PJ, Jousilahti P, Alfthan G, Palosuo T, Asikainen S, Salomaa V. Antibodies to periodontal pathogens are associated with coronary heart disease. Arterioscler Thromb Vasc Biol 2003;23:1250-1254.
11. Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S. Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med 2003;163:1172-1179.
12. Syrjanen J, Peltola J, Valtonen V, Iivanainen M, Kaste M, Huttunen JK. Dental infections in association with cerebral infarction in young and middle-aged men. J Intern Med 1989;225:179-184.
13. Beck JD, Elter JR, Heiss G, Couper D, Mauriello MS, Offenbacher S. Relationship of periodontal disease to carotid artery intimal-media wall thickness: The Atherosclerosis Risk In Communities (ARIC) Study. Arterioscler Thromb Vasc Biol 2001;21:1816-1822.
14. Arbes SJ Jr., Slade GD, Beck JD. Association between extent of periodontal attachment loss and self-reported history of heart attack: An analysis of NHANES III data. J Dent Res 1999;78:1777-1782.
15. Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol 2003;23: 1245-1249.
16. Desvarieux M, Demmer RT, Rundek T, et al. Relationship between periodontal disease, tooth loss, and carotid artery plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Stroke 2003; 34:2120-2125.
17. Elter JR, Offenbacher S, Toole JF, Beck JD. Relationship of periodontal disease and edentulism to stroke/ TIA. J Dent Res 2003;82:998-1001.
18. Emingil G, Buduneli E, Aliyev A, Akilli A, Atilla G. Association between periodontal disease and acute myocardial infarction. J Periodontol 2000;71:1882-1886.
19. Engebretson SP, Lamster IB, Elkind MS, et al. Radiographic measures of chronic periodontitis and carotid artery plaque. Stroke 2005;36:561-566.
20. Genco RJ, Wu TJ, Grossi S, Falkner K, Zambon JJ, Trevisan M. Periodontal microflora related to the risk for myocardial infarction: A case-control study. J Dent Res 1999;78:457.
21. Grau A, Buggle F, Ziegler C, et al. Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke 1997;28:1724-1729.
22. Joshipura KJ, Wand HC, Merchant AT, Rimm EB. Periodontal disease and biomarkers related to cardiovascular disease. J Dent Res 2004;83:151-155.
23. Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 2003;34:47-52.
24. Hung H-C, Joshipura K, Colditz G, et al. The association between tooth loss and coronary heart disease in men and women. J Public Health. Dent 2004;64:209-215.
25. Hung HC, Willett W, Merchant A, Rosner BA, Ascherio A, Joshipura KJ. Oral health and peripheral arterial disease. Circulation 2003;107:1152-1157.
26. DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. BMJ 1993;306:688-691.
27. Beck JD, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol 1996;67(10 Suppl.):1123-1137.
28. Manila K, Valtonen V, Nieminen M, Huttunen J. Dental infection and the risk of new coronary events: Prospective study of patients with documented coronary artery disease. Clin Infect Dis 1995;20:588-592.
29. Morrison HI, Ellison LF, Taylor GW. Periodontal disease and risk of fatal coronary heart and cerebrovascular disease. J Cardiovasc Risk 1999;6:7-11.
30. Pussinen PJ, Alfthan G, Tuomilehto J, Asikainen S, Jousilahti P. High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction. Eur J Cardiovasc Prev Rehabil 2004;11:408-411.
31. Pussinen PJ, Alfthan G, Rissanen H, Reunanen A, Asikainen S, Knekt P. Antibodies to periodontal pathogens and stroke risk. Stroke 2004;35:2020-2023.
32. Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willett WC. Poor oral health and coronary heart disease. J Dent Res 1996;75:1631-1636.
33. Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Periodontal disease and coronary heart disease risk. JAMA 2000;284:1406-1410.
34. Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Examining the link between coronary heart disease and the elimination of chronic dental infections. J Am Dent Assoc 2001;132:883-889.
35. Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Periodontitis-systemic disease associations in the presence of smoking - Causal or coincidental? Periodontol 2000 2002;30:51-60.
36. Howell TH, Ridker PM, Ajani UA, Hennekens CH, Christen WG. Periodontal disease and risk of subsequent cardiovascular disease in U.S. male physicians. J Am Coll Cardiol 2001;37:445-450.
37. Tuominen R, Reunanen A, Paunio M, Paunio I, Aromaa A. Oral health indicators poorly predict coronary heart disease deaths. J Dent Res 2003;82:713-718.
38. Herzberg MC, Brintzenhofe KL, Clawson CC. Aggregation of human platelets and adhesion of Streptococcus sanguis. Infect Immun 1983;39:1457-1469.
39. Herzberg M, Meyer M. Effects of oral flora on platelets: Possible consequences in cardiovascular disease. J Periodontol 1996;67(10 Suppl.):1138-1142.
40. Haraszthy V, Zambon J, Trevisan M, Zeid M, Genco R. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000;71:1554-1560.
41. Dorn B, Dunn WJ, Progulske-Fox A. Invasion of human coronary artery cells by periodontal pathogens. Infect Immun. 1999;67:5792-5798.
42. Deshpande RG, Khan MB, Genco CA. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun 1998;66:5337-5343.
43. Lalla E, Lamster I, Spessot A, et al. Oral infection with an established periodontal pathogen accelerates atherosclerosis in APO E null mice. Circulation 2000; 102(Suppl. II):II41-II42(Abstr. 188).
44. Castell JV, Andus T, Kunz D, Heinrich PC. Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat. Ann N YAcad Sci 1989;557:87-99.
45. Yamauchi-Takihara K, Ihara Y, Ogata A, Yoshizaki K, Azuma J, Kishimoto T. Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 1995;91: 1520-1524.
46. Wu T, Trevisan M, Genco RJ, Dorn JP, Falkner KL, Sempos CT. Periodontal disease and risk of cerebrovascular disease: The First National Health and Nutrition Examination Survey and its follow-up study. Arch Intern Med 2000;160:2749-2755.
47. Slade GD, OffenbacherS, Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res 2000;79:49-57.
48. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: Meta-analyses of prospective studies. JAMA 1998;279:1477-1482.
49. Liuzzo G, Biasucci LM, Gallimore JR, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 1994; 331:417-424.
50. Pietila K, Harmoinen A, Hermens W, Simoons ML, Van de Werf F, Verstraete M. Serum C-reactive protein and infarct size in myocardial infarct patients with a closed versus an open infarct-related coronary artery after thrombolytic therapy. Eur Heart J 1993;14:915-919.
51. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-843.
52. Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis: A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 2001;285:2481-2485.
53. D'Aiuto F, Parkar M, Nibali L, Suvan J, Lessem J, Tonetti M. Periodontal infections cause changes in traditional and novel risk factors: Results from a randomized controlled clinical trial. Am Heart J 2006;151:977-984.
54. Berkman L, Blumenthal J, Burg M, et al. Effects of treating depression and low perceived social support on clinical event after myocardial infarction: The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA 2003;289: 3106-3116.
55. Beck JD, Couper DJ, Falkner KL, et al. The Periodontitis and Vascular Events (PAVE) pilot study: Adverse events. J Periodontol 2008;79:90-96.