The antioxidant effect of lovastatin on phagocyte-induced DNA damage: Implications for cancer prevention

Journal of Experimental and Clinical Cancer Research

Volumn 26, Issue 4, 2007, Pages 583-586

  Weitberg, Alan B ^a  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

Author keywords

Antioxidants; DNA damage; HMG CoA reductase inhibitors; Inflammation

Indexed keywords

ACID; CYTOCHROME C; DOUBLE STRANDED DNA; HYDROGEN PEROXIDE; LACTONE; MEVINOLIN; PHORBOL ESTER; SUPEROXIDE;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; DNA DAMAGE; DNA DENATURATION; DNA STRAND BREAKAGE; DRUG EFFECT; FETUS; FLUOROMETRY; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MAMMAL CELL; PHAGOCYTE; PRIORITY JOURNAL;

ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; DNA DAMAGE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; NEOPLASMS; PHAGOCYTES; REACTIVE OXYGEN SPECIES;

EID: 38549121817     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Shovman O., Levy Y., Gilburd B., Shoenfeld Y.: Antiinflammatory and immunomodulatory properties of statins. Immunol Res. 25:271-285, 2002.
2. Cerutti P.A.: Prooxidant states and tumor promotion. Science. 227:375-381, 1985.
3. Weitzman S.A., Weitberg A.B., Clark E.P., Stossel T.P.: Phagocytes as carcinogens: malignant transformation produced by human heutrophils. Science. 227:1231-1233, 1985.
4. Birnboim H.C., Jevcak J.J.: Fluorometric method for the rapid detection of DNA strand breaks in human white cells produced by low doses of radiation. Cancer Res. 41:1889-1892, 1981.
5. McCord J.M., Fridovich I.: Superoxide dismutase. An enzymatic function of erythrocuprein (hemocuprein). J. Biol. Chem. 244:6049-6055, 1969.
6. Bovcris A., Oshino N., Chance B.: The cellular production of hydrogen peroxide. Biochem. J. 128:617-630, 1972.
7. Pick E., Mizel D.: Rapid microassays for the measurement of superoxide and hydrogen peroxide by macrophages in using automatic enxyme immunoassay reader. J. Immunol. Methods. 46:211-226, 1981.
8. Yoshida M.: Potential role of statins in inflammation and atherosclerosis. J. Atheroscler. Thromb. 10:140-144,2003.
9. Wassman S., Nickenig G.: Interrelationship of free oxygen radicals and endothelial dysfunction - modulation by statins. Endothelium. 10:23-33, 2003.
10. Shishehbor M.H., Brennan M.L., Aviles R.J. et al.: Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation. 108:426-431, 2003.
11. Wassman S., Laufs U., Muller K. et al.: Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 22:300-305, 2002.
12. Giroux L.M., Davignon J., Naruszewicz M.: Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. Biochimica et Biophysica Acta. 1165:335-338, 1993.
13. Weitberg A.B., Weitzman S.A., Destrempes M., Latt S.A., Stossel T.P.: Stimulated human phagocytes produce cytogenetic changes in cultured mammalian cells. N. Engl. J. Med. 308:26-29, 1983.
14. Weitzman S.A., Stossel T.P.: Mutation caused by human phagocytes. Science. 212:546-547, 1981.