Gene expression profiling in Paget's disease of bone: Upregulation of interferon signaling pathways in pagetic monocytes and lymphocytes

Journal of Bone and Mineral Research

Volumn 23, Issue 2, 2008, Pages 253-259

  Nagy, Zsolt B ^a,b   Gergely Jr , Péter ^a,b   Donáth, Judit ^a   Borgulya, Gábor ^a   Csanád, Mónika ^a   Poór, Gyula ^a,b  

^a NATIONAL INSTITUTE OF RHEUMATOLOGY AND PHYSIOTHERAPY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Gene expression; Interferon; Lymphocyte; Monocyte; Paget's disease of bone

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GAMMA INTERFERON RECEPTOR 2; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE P38; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE METABOLISM; BONE REMODELING; BONE TURNOVER; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; IFN ALPHA GENE; IFN BETA GENE; IFN GAMMA GENE; IFN GAMMAR1 GENE; IFN GAMMAR2 EGNE; LYMPHOCYTE; MALE; MONOCYTE; NUCLEOTIDE SEQUENCE; OSTEOCLAST; P38 BETA2 MAPK GENE; PAGET BONE DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 GENE; TNF ALPHA GENE;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERFERON TYPE II; LYMPHOCYTES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MONOCYTES; OSTEITIS DEFORMANS; SIGNAL TRANSDUCTION;

EID: 38549119003     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.071021     Document Type: Article

References (40)

1. Maldague B, Malghem J 1987 Dynamic radiologic patterns of Paget's disease of bone. Clin Orthop 217:126-251.
2. Roodman GD, Windle JJ 2005 Paget disease of bone. J Clin Invest 115:200-208.
3. Poor G, Donath J, Fornet B, Cooper C 2006 Epidemiology of Paget's disease in Europe: The prevalence is decreasing. J Bone Miner Res 10:1545-1549.
4. Morales-Piga AA, Rey-Rey JS, Corres-Gonzales J, Garcia-Sagredo JM, Lopez-Abente G 1995 Frequency and characteristics of familial aggregation of Paget's disease of bone. J Bone Miner Res 10:663-670.
5. Laurin N, Brown JP, Morissette J, Raymond V 2001 Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am J Hum Genet 69:528-543.
6. Good DA, Busfield F, Fletcher BH, Duffy DL, Kesting JB, Andersen J, Shaw JT 2002 Linkage of Paget disease of bone to a novel region on human chromosome 18q23. Am J Hum Genet 70:517-525.
7. Johnson-Pais TL, Wisdom JH, Weldon KS, Cody JD, Hansen MF, Singer FR, Leach RJ 2003 Three novel mutations in SQSTM1 identified in familial Paget's disease of bone. J Bone Miner Res 18:1748-1753.
8. Nakatsuka K, Nishizawa Y, Raltson SH 2003 Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A gene. J Bone Miner Res 18:1381-1385.
9. Kurihara N, Hiruma Y, Zhou H, Subler MA, Dempster DW, Singer FR, Reddy SV, Gruber HE, Windle JJ, Roodman GD 2007 Mutation of the SQSTM1 (p62) gene increases osteoclastogenesis but does not induce PD. J Clin Invest 117:133-142.
10. Geetha T, Wooten MW 2002 Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett 512:19-24.
11. Campbell IA, Douglas JG, Francis RM, Prescott RJ, Reid DM 2004 Five year study of etidronate and/or calcium as prevention and treatment for osteoporosis and fractures in patients with asthma receiving long term oral and/or inhaled glucocorticoids. Thorax 59:761-768.
12. Hirayama T, Sabokbar A, Athanasou NA 2002 Effect of corticosteroids on human osteoclast formation and activity. J Endocrinol 175:155-163.
13. Takuma A, Kaneda T, Sato T, Ninomiya S, Kumegawa M, Hakeda Y 2003 Dexamethasone enhances osteoclast formation synergistically with transforming growth factor-beta by stimulating the priming of osteoclast progenitors for differentiation into osteoclasts. J Biol Chem 278:44667-44674.
14. Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, De Jong FH, Lamberts SW 1998 A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. Clin Endocrinol Metab 83:144-151.
15. Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L 2006 Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem 281:11846-11855.
16. Yogesha SD, Shruti M, Khapli M, Wani MR 2005 Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor inhibits Tumor Necrosis Factor (TNF)-α-induced osteoclast differentiation by down-regulation of expression of TNF receptors 1 and 2. J Biol Chem 280:11759-11769.
17. van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C 2002 Incidence and natural history of Paget's disease of bone in England and Wales. J Bone Miner Res 17:465-471.
18. Doyle T, Gunn J, Anderson G, Gill M, Cundy T 2002 Paget's disease in New Zealand: evidence for declining prevalence. Bone 31:616-619.
19. Mills BG, Singer FR, Weiner LP, Suffin SC, Stabile E, Holst P 1984 Evidence for both respiratory syncytial virus and measles virus antigens in the osteoclast of patients with Paget's disease of bone. Clin Orthop 183:303-311.
20. Gattoni A, Parlato A, Vangieri B, Bresciani M, Dema R 2006 Interferon-gamma biologic functions and HCV therapy (type I/II) (2 of 2 parts). Clin Ter 157:457-468.
21. Mills BG, Frausto A, Singer FR, Ohsaki Y, Demulder A, Roodman GD 1994 Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens. Bone 15:443-448.
22. Isaacs A, Lindenmann J 1957 Virus interference. The interferon. Proc R Lond Soc Biol Sci 147:258-267.
23. Biron CA 2001 Interferon α and β as immune regulators - a new look. Immunity 14:661-664.
24. Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, Auget M 1994 Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
25. Kotake S, Nanke Y, Mogi M, Kawamoto M, Furuya T, Yago T, Kobashigawa T, Togari A, Kamatani N 2005 IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol 35:3353-3363.
26. Aaronson DS, Horvath CM 2002 A road map for those who don't know JAK-STAT. Science 296:1653-1655.
27. Weitzmann MN, Pacifici R 2005 The role of T lymphocytes in bone metabolism. Immunol Rev 208:154-168.
28. Shinoda K, Sugiyama FE, Taki H, Harada S, Mino T, Maruyama M, Kobayashi M 2003 Resting T cells negatively regulate osteoclast generation from peripheral blood monocytes. Bone 33:711-720.
29. Fox SW, Chambers TJ 2000 Interferon-γ directly inhibits TRANCE-induced osteoclastogenesis. Biochem Biophys Res Commun 276:868-872.
30. Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe J, Recker RR, Deng HW 2005 A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem 32:29011-29016.
31. Kee CG, Jaharulhaque S, Williams RG 1999 p38 MAP Kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18:5601-5608.
32. Kim N, Kadono Y, Takami M, Lee J, Lee SH, Okada F, Kim JH, Kobayashi T, Odgren PR, Nakano H, Yeh WC, Lee K, Lorenzo JA, Choi Y 2005 Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med 202:589-595.
33. Hocking L, Slee F, Haslam SI, Cundy T, Nicholson T, van Hul W, Ralston SH 2000 Familial Paget's disease of bone: Patterns of inheritance and frequency of linkage to chromosome 18q. Bone 6:577-580.
34. Hocking LJ, Lucas GJ, Daroszewska A, Cundy T, Nicholson GC, Donath J, Walsh JP, Finlayson C, Cavey JR, Ciani B, Sheppard PW, Searle MS, Layfield R, Ralston SH 2004 Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: Genotype phenotype correlation, functional analysis, and structural consequences. J Bone Miner Res 7:1122-1127.
35. Li X, Udagawa N, Itoh K, Suda K, Murase Y, Nishihara T, Suda T, Takahashi N 2002 p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology 8:3105-3113.
36. Vollstedt S, Arnold S, Schwerdel C, Franchini M, Alber G, Di Santo JP, Ackermann M, Suter M 2004 Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense againts herpes simplex virus type 1. J Virol 8:3846-3850.
37. Rath PC, Aggarwal BB 1999 TNF-induced signaling in apoptosis. J Clin Immunol 19:350-364.
38. Takayanagi H, Sato K, Takaoka A, Taniguchi T 2005 Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 208:181-193.
39. Brandwood CP, Hoyland JA, Hillarby MC, Berry JL, Davies M, Selby PL, Mee AP 2003 Apoptotic gene expression in Paget's disease: A possible role for Bcl-2. J Pathol 201:504-512.
40. Naot D, Bava U, Matthews B, Callon KE, Gamble GD, Black M, Song S, Pitto RP, Cundy T, Cornish J, Reid IR 2007 Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone. J Bone Miner Res 22:298-309.