Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation

Reproduction, Fertility and Development

Volumn 20, Issue 2, 2008, Pages 247-252

  Marquez, Becky ^a   Suarez, Susan S ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Sperm motility

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; BICARBONATE; BUCLADESINE; CALCIUM ION; CYCLIC AMP ACETOXYMETHYL ESTER; CYCLIC AMP DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; MALE; MOUSE; NONHUMAN; NULL ALLELE; SIGNAL TRANSDUCTION; SPERMATOZOON MOTILITY; WILD TYPE;

ADENYLATE CYCLASE; AMMONIUM CHLORIDE; ANIMALS; BUCLADESINE; MALE; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SPERM CAPACITATION; SPERM MOTILITY; THIMEROSAL;

MUS;

EID: 38549116059     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD07146     Document Type: Article

References (35)

1. Blusztajn, J. K. (1992). Acetylcholine synthesis and release is enhanced by dibutyryl cyclic AMP in a neuronal cell line derived from mouse septum. J. Neurosci. 12, 793-799.
2. Carrera, A., Moos, J., Ning, X. P., Gerton, G. L., Tesarik, J., Kopf, G. S., and Moss, S. B. (1996). Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation. Dev. Biol. 180, 284-296. doi:10.1006/DBIO.1996.0301
3. Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., and Buck, J. (2000). Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289, 625-628. doi:10.1126/SCIENCE.289.5479.625
4. DeMott, R. P., and Suarez, S. S. (1992). Hyperactivated sperm progress in the mouse oviduct. Biol. Reprod. 46, 779-785. doi:10.1095/BIOLREPROD46.5.779
5. Esposito, G., Jaiswal, B. S., Xie, F., Krajnc-Franken, M. A. M., Robben, T. J. A. A., et al. (2004). Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc. Natl. Acad. Sci. USA 101, 2993-2998. doi:10.1073/PNAS.0400050101
6. Hess, K. C., Jones, B. H., Marquez, B., Chen, Y., Ord, T. S., et al. (2005). Bicarbonate responsive 'soluble' adenylyl cyclase is responsible for multiple specific signaling events in mammalian sperm required for fertilization. Dev. Cell 9, 249-259. doi:10.1016/J.DEVCEL.2005.06. 007
7. 2+ store is involved in regulating sperm hyperactivated motility. Biol. Reprod. 65, 1606-1615. doi:10.1095/BIOLREPROD65.5.1606
8. Hyne, R. V., and Garbers, D. L. (1979). Regulation of guinea pig sperm adenylate cyclase by calcium. Biol. Reprod. 21, 1135-1142. doi:10.1095/BIOLREPROD21.5.1135
9. Jaiswal, B. S., and Conti, M. (2003). Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc. Natl. Acad. Sci. USA 100, 10676-10681. doi:10.1073/PNAS.1831008100
10. Katz, D. F., and Yanagimachi, R. (1980). Movement characteristics of hamster spermatozoa within the oviduct. Biol. Reprod. 22, 759-764. doi:10.1095/BIOLREPROD22.4.759
11. 2+ channel. Nature 439, 737-740. doi:10.1038/ NATURE04417
12. Litvin, T. N., Kamenetsky, A. Z., Buck, J., and Levin, L. R. (2003). Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate. J. Biol. Chem. 278, 15922-15926. doi:10.1074/JBC. M212475200
13. Marquez, B., and Suarez, S. S. (2004). Different signalling pathways in bovine sperm regulate capacitation and hyperactivation. Biol. Reprod. 70, 1626-1633. doi:10.1095/BIOLREPROD.103.026476
14. 2+ influx. Biol. Reprod. 76, 660-665. doi:10.1095/BIOLREPROD.106.055038
15. Mortimer, S. T., and Mortimer, D. (1990). Kinematics of human spermatozoa incubated under capacitating conditions. J. Androl. 11, 195-203.
16. Naaby-Hansen, S., Mandal, A., Wolkowicz, M. J., Sen, B., Westbrook, V. A., et al. (2002). CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. Dev. Biol. 242, 236-254. doi:10.1006/DBIO.2001.0527
17. Neill, J. M., and Olds-Clarke, P. (1987). A computer-assisted assay for mouse sperm hyperactivation demonstrates that bicarbonate but not bovine serum albumin is required. Gamete Res. 18, 121-140. doi:10.1002/MRD. 1120180204
18. Okamura, N., Tajima, Y., Soejima, A., Masuda, H., and Sugita, Y. (1985). Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. J. Biol. Chem. 260, 9699-9705.
19. Quill, T. A., Sugden, S. A., Ross, K. L., Doolittle, L. K., Hammer, R. E., and Garbers, D. L. (2003). Hyperactivated spermmotility driven by CatSper2 is required for fertilization. Proc. Natl. Acad. Sci. USA 100, 14869-14874. doi:10.1073/PNAS.2136654100
20. 2+ permeation pathway present in male germ cells with possible roles in spermatogenesis and mature sperm function. J. Gen. Physiol. 112, 33-35. doi:10.1085/JGP.112.1.33
21. Si, Y., and Okuno, M. (1999). Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation. Biol. Reprod. 61, 240-246. doi:10.1095/BIOLREPROD61.1.240
22. Stauss, C. R., Votta, T. J., and Suarez, S. S. (1995). Spermmotility hyperactivation facilitates penetration of the hamster zona pellucida. Biol. Reprod. 53, 1280-1285. doi:10.1095/BIOLREPROD53.6.1280
23. Suarez, S. S. (1987). Sperm transport and motility in the mouse oviduct: observations in situ. Biol. Reprod. 36, 203-210. doi:10.1095/BIOLREPROD36.1.203
24. Travis, A. J., Jorgez, C. J., Merdiushev, T., Jones, B. H., Dess, D. M., Diaz-Cueto, L., Storey, B. T., Kopf, G. S., and Moss, S. B. (2001). Functional relationships between capacitation-dependent cell signalling and compartmentalized metabolic pathways in murine spermatozoa. J. Biol. Chem. 276, 7630-7636. doi:10.1074/JBC.M006217200
25. Vijayaraghavan, S., Critchlow, L. M., and Hoskins, D. D. (1985). Evidence for a role for cellular alkalinization in the cyclic adenosine 3′,5′-monophosphate-mediated initiation of motility in bovine caput spermatozoa. Biol. Reprod. 32, 489-500. doi:10.1095/BIOLREPROD32. 3.489
26. Visconti, P. E., Bailey, J. L., Moore, G. D., Pan, D., Olds-Clarke, P., and Kopf, G. S. (1995a). Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 121, 1129-1137.
27. Visconti, P. E., Moore, G.D., Bailey, J. L., Leclerc, P., Connors, S. A., Pan, D., Olds-Clarke, P., and Kopf, G. S. (1995b). Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development 121, 1139-1150.
28. Visconti, P. E., Galantino-Homer, H., Ning, X. P., Moore, G. D., Valenzuela, P., Jorgez, C. J., Alvarez, J. G., and Kopf, G. S. (1999). Cholesterol efflux-mediated signal transduction in mammalian sperm. J. Biol. Chem. 274, 3235-3242. doi:10.1074/JBC.274.5.3235
29. 2+-channel responses: initial events in sperm activation. Development 130, 1317-1326. doi:10.1242/DEV.00353
30. Whitten, W. K. (1971). Nutrient requirements for the culture of preimplantation embryos in vitro. Adv. Biosci. 6, 129-139.
31. Wiechmann, A. F., Kyritsis, A. P., Fletcher, R. T., and Chader, G. J. (1990). Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells. J. Neurochem. 55, 208-214. doi:10.1111/J.1471-4159.1990.TB08840.X
32. 2+ entry into sperm. J. Cell Biol. 142, 473-484. doi:10.1083/JCB.142.2.473
33. Xie, F., Garcia, M. A., Carlson, A. E., Schuh, S. M., Babcock, D. F., Jaiswal, B. S., Gossen, J. A., Esposito, G., van Duin, M., and Conti, M. (2006). Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev. Biol. 296, 353-362. doi:10.1016/J.YDBIO.2006. 05.038
34. Yanagimachi, R. (1970). The movement of golden hamster spermatozoa before and after capacitation. J. Reprod. Fertil. 23, 193-196.
35. Yanagimachi, R. (1994). Mammalian fertilization. In 'The Physiology of Reproduction'. (Eds E. Knobil and J. Neill.) pp. 189-317. (Raven Press: New York.)