Persistent hypertension and progressive renal injury induced by salt overload after short term nitric oxide inhibition

Clinics

Volumn 62, Issue 6, 2007, Pages 749-756

  Mattar, Ana Lúcia ^a   Machado, Flávia Gomes ^a   Fujihara, Clarice Kazue ^a   Malheiros, Denise Maria Avancini Costa ^a   Zatz, Roberto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin II; AT 1 receptor blocker; Chronic kidney disease; Mycophenolate mofetil; Salt overload

Indexed keywords

EID: 38549115116     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322007000600015     Document Type: Article

References (28)

1. Ribeiro MO, Antunes E, De Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension. 1992;20:298-303.
2. Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest. 1992;90:278-281.
3. Zatz R, Baylis C. Chronic Nitric Oxide Inhibition Model Six Years On. Hypertension. 1998;32:958-964.
4. Fujihara CK, Michellazzo SM, De Nucci G, Zatz R. Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition. Am J Physiol. 1994;266:F697-705.
5. Fujihara CK, Sena CR, Malheiros DM, Mattar AL, Zatz R. Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury. Am J Physiol Renal Physiol. 2006;290:F632-40.
6. Quiroz Y, Pons H, Gordon KL, Rincon J, Chavez M, Parra G et al. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition. Am J Physiol Renal Physiol. 2001;281:F38-47.
7. Fujihara CK, De Nucci G, Zatz R. Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy. J Am Soc Nephrol. 1995;5:1498-1507.
8. Matavelli LC, Zhou X, Varagic J, Susic D, Frohlich ED. Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2007;292:H814-19.
9. Tian N, Gu JW, Jordan S, Rose RA, Hughson MD, Manning RD, Jr. Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol. 2007;292:H1018-25.
10. Roson MI, Cavallero S, Della PS, Cao G, Gorzalczany S, Pandolfo M et al. Acute sodium overload produces renal tubulointerstitial inflammation in normal rats. Kidney Int. 2006;70:1439-1446.
11. Franco M, Martinez F, Rodriguez-Iturbe B, Johnson RJ, Santamaria J, Montoya A et al. Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2006;291:F1281-F1287.
12. Sanders PW. Effect of salt intake on progression of chronic kidney disease. Curr Opin Nephrol Hypertens. 2006;15:54-60.
13. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965;2:235-254.
14. Jepsen FL, Mortensen PB. Interstitial fibrosis of the renal cortex in minimal change lesion and its correlation with renal function. A quantitative study. Virchows Arch A Pathol Anat Histol. 1979;383:265-270.
15. Goncalves AR, Fujihara CK, Mattar AL, Malheiros DMAC, Noronha IL, De Nucci G et al. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. Am J Physiol Renal Physiol. 2004;286:F945-954.
16. Daniels BS, Hostetter TH. Adverse effects of growth in the glomerular microcirculation. Am J Physiol. 1990;258:F1409-1416.
17. Fujihara CK, Velho M, Malheiros DMAC, Zatz R. An extremely high dose of losartan affords superior renoprotection in the remnant model. Kidney Int. 2005;67:1913-1924.
18. Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS et al. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest. 1999;104:1693-1701.
19. Grafe M, Auch-Schwelk W, Zakrzewicz A, Regitz-Zagrosek V, Bartsch P, Graf K et al. Angiotensin II-induced leukocyte adhesion on human coronary endothelial cells is mediated by E-selectin. Circ Res. 1997;81:804-811.
20. Ruiz-Ortega M, Ruperez M, Lorenzo O, Esteban V, Blanco J, Mezzano S et al. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int Suppl. 2002;8212-22.
21. Wolf G. Renal injury due to renin-angiotensin-aldosterone system activation of the transforming growth factor-beta pathway. Kidney Int. 2006;70:1914-1919.
22. Fujihara CK, Malheiros DMAC, Zatz R, Noronha IL. Mycophenolate mofetil attenuates renal injury in the rat remnant kidney. Kidney Int. 1998;54:1510-1519.
23. Romero F, Rodriguez-Iturbe B, Parra G, Gonzalez L, Herrera-Acosta J, Tapia E. Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. Kidney Int. 1999;55:945-955.
24. Utimura R, Fujihara CK, Mattar AL, Malheiros DM, Noronha IL, Zatz R. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int. 2003;63:209-216.
25. Fujihara CK, Malheiros DMAC, Noronha IL, De Nucci G, Zatz R. Mycophenolate Mofetil Reduces Renal Injury in the Chronic Nitric Oxide Synthase Inhibition Model. Hypertension. 2001;37:170-175.
26. Hamar P, Peti-Peterdi J, Razga Z, Kovacs G, Heemann U, Rosivall L. Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney. J Am Soc Nephrol. 1999;10 Suppl 11:S234-238.
27. Remuzzi G, Zoja C, Gagliardini E, Corna D, Abbate M, Benigni A. Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals. J Am Soc Nephrol. 1999;10:1542-1549.
28. Fujihara CK, Noronha IL, Malheiros DMAC, Antunes GR, Oliveira IB, Zatz R. Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney. J Am Soc Nephrol. 2000;11:283-290.