Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 3, 2006, Pages

  Fujihara, Clarice K ^a   Sena, Claudia R ^a   Malheiros, Denise M A C ^a   Mattar, Ana L ^a   Zatz, Roberto ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Laboratorio de Fisiopatologia Renal   (Brazil)

Author keywords

Angiotensin II; Kidney glomerulus physiopathology; N L nitro arginine methyl ester; Type 1 angiotensin receptor

Indexed keywords

ALBUMIN; LOSARTAN POTASSIUM; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SODIUM CHLORIDE; ENZYME INHIBITOR;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; GLOMERULAR DYSFUNCTION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY STRUCTURE; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; REMISSION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; HEMODYNAMICS; KIDNEY; KIDNEY CIRCULATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SODIUM INTAKE; URODYNAMICS; WISTAR RAT;

ANIMALS; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; KIDNEY; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RATS; RATS, WISTAR; RENAL CIRCULATION; SODIUM, DIETARY; URODYNAMICS;

EID: 33645561479     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00259.2005     Document Type: Article

References (39)

1. Akai Y, Homma T, Burns KD, Yasuda T, Badr KF, and Harris RC. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol Cell Physiol 267: C482-C490, 1994.
2. Alvarez V, Quiroz Y, Nava M, Pons H, and Rodriguez-Iturbe B. Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells. Am J Physiol Renal Physiol 283: F1132-F1141, 2002.
3. Anderson S, Diamond JR, Karnovsky MJ, and Brenner BM. Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome. J Clin Invest 82: 1757-1768, 1988.
4. Anderson S, Meyer TW, Rennke HG, and Brenner BM. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 76: 612-619, 1985.
5. Arcos MI, Fujihara CK, Sesso A, Prado EBA, Prado MJA, de Nucci G, and Zatz R. Mechanisms of albuminuria in the chronic nitric oxide inhibition model. Am J Physiol Renal Physiol 279: F1060-F1066, 2000.
6. Baylis C, Mitruka B, and Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest 90: 278-281, 1992.
7. Becker BN, Yasuda T, Kondo S, Vaikunth S, Homma T, and Harris RC. Mechanical stretch/relaxation stimulates a cellular renin-angiotensin system in cultured rat mesangial cells. Exp Nephrol 6: 57-66, 1998.
8. Boffa JJ, Lu Y, Placier S, Stefanski A, Dussaule JC, and Chatziantoniou C. Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases. J Am Soc Nephrol 14: 1132-1144, 2003.
9. Bonsib SM. Focal-segmental glomerulosclerosis. The relationship between tubular atrophy and segmental sclerosis. Am J Clin Pathol 111: 343-348, 1999.
10. Fioretto P, Steffes MW, Sutherland DE, Goetz FC, and Mauer M. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 339: 69-75, 1998.
11. Floege J, Alpers CE, Burns MW, Pritzl P, Gordon K, Couser WG, and Johnson RJ. Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model. Lab Invest 66: 485-497, 1992.
12. Fujihara CK, Malheiros DMAC, Noronha IL, de Nucci G, and Zatz R. Mycophenolate mofetil reduces renal injury in the chronic nitric oxide synthase inhibition model. Hypertension 37: 170-175, 2001.
13. Fujihara CK, Malheiros DMAC, Zatz R, and Noronha IL. Mycophenolate mofetil attenuates renal injury in the rat remnant kidney. Kidney Int 54: 1510-1519, 1998.
14. Fujihara CK, Michellazzo SM, de Nucci G, and Zatz R. Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition. Am J Physiol Renal Fluid Electrolyte Physiol 266: F697-F705, 1994.
15. Fujihara CK, Velho M, Malheiros DMAC, and Zatz R. An extremely high dose of losartan affords superior renoprotection in the remnant model. Kidney Int 67: 1913-1924, 2005.
16. Goncalves AR, Fujihara CK, Mattar AL, Malheiros DMAC, Noronha IL, de Nucci G, and Zatz R. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. Am J Physiol Renal Physiol 286: F945-F954, 2004.
17. Graciano ML, Cavaglieri RdC, Delle H, Dominguez WV, Casarini DE, Malheiros DMAC, and Noronha IL. Intrarenal renin-angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 15: 1805-1815, 2004.
18. Hirakata M, Kaname S, Chung UG, Joki N, Hori Y, Noda M, Takuwa Y, Okazaki T, Fujita T, Katoh T, and Kurokawa K. Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells. Kidney Int 51: 1028-1036, 1997.
19. Hughson MD, Johnson K, Young RJ, Hoy WE, and Bertram JF. Glomerular size and glomerulosclerosis: relationships to disease categories, glomerular solidification, and ischemic obsolescence. Am J Kidney Dis 39: 679-688, 2002.
20. Jepsen FL and Mortensen PB. Interstitial fibrosis of the renal cortex in minimal change lesion and its correlation with renal function. A quantitative study. Virchows Arch A Pathol Anat Histol 383: 265-270, 1979.
21. Kagami S, Border WA, Miller DE, and Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells. J Clin Invest 93: 2431-2437, 1994.
22. Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, and Scholey JW. Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. J Am Soc Nephrol 14: 2790-2800, 2003.
23. Kriz W and LeHir M. Pathways to nephron loss starting from glomerular diseases-insights from animal models. Kidney Int 67: 404-419, 2005.
24. Ma LJ, Nakamura S, Aldigier JC, Rossini M, Yang H, Liang X, Nakamura I, Marcantoni C, and Fogo AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J Am Soc Nephrol 16: 966-976, 2005.
25. Mezzano S, Aros C, Droguett A, Burgos ME, Ardiles L, Flores C, Schneider H, Ruiz-Ortega M, and Egido J. NF-κB activation and overexpression of regulated genes in human diabetic nephropathy. Nephrol Dial Transplant 19: 2505-2512, 2004.
26. Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, Ruiz P, Smithies O, and Coffman TM. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest 104: 1693-1701, 1999.
27. Navarro-Cid J, Maeso R, Rodrigo E, Munoz-Garcia R, Ruilope LM, Lahera V, and Cachofeiro V. Renal and vascular consequences of the chronic nitric oxide synthase inhibition. Effects of antihypertensive drugs. Am J Hypertens 9: 1077-1083, 1996.
28. 1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats. Kidney Int 65: 972-981, 2004.
29. Quiroz Y, Pons H, Gordon KL, Rincon J, Chavez M, Parra G, Herrera-Acosta J, Gomez-Garre D, Largo R, Egido J, Johnson RJ, and Rodriguez-Iturbe B. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition. Am J Physiol Renal Physiol 281: F38-F47, 2001.
30. Remuzzi A, Gagliardini E, Donadoni C, Fassi A, Sangalli F, Lepre MS, Remuzzi G, and Benigni A. Effect of angiotensin II antagonism on the regression of kidney disease in the rat. Kidney Int 62: 885-894, 2002.
31. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, and Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 20: 298-303, 1992.
32. Riser BL, Cortes P, Heilig C, Grondin J, Ladson-Wofford S, Patterson D, and Narins RG. Cyclic stretching force selectively up-regulates transforming growth factor-β isoforms in cultured rat mesangial cells. Am J Pathol 148: 1915-1923, 1996.
33. Rodriguez-Iturbe B, Pons H, Quiroz Y, Gordon K, Rincon J, Chavez M, Parra G, Herrera-Acosta J, Gomez-Garre D, Largo R, Egido J, and Johnson RJ. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure. Kidney Int 59: 2222-2232, 2001.
34. Ruiz-Ortega M, Bustos C, Hernandez-Presa MA, Lorenzo O, Plaza JJ, and Egido J. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-κB activation and monocyte chemoattractant protein-1 synthesis. J Immunol 161: 430-439, 1998.
35. Takebayashi S, Kiyoshi Y, Hisano S, Uesugi N, Sasatomi Y, Meng J, and Sakata N. Benign nephrosclerosis: incidence, morphology and prognosis. Clin Nephrol 55: 349-356, 2001.
36. Utimura R, Fujihara CK, Mattar AL, Malheiros DMAC, Noronha IL, and Zatz R. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int 63: 209-216, 2003.
37. Wallenstein S, Zucker CL, and Fleiss JL. Some statistical methods useful in circulation research. Circ Res 47: 1-9, 1980.
38. 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin system. Kidney Int 51: 1553-1567, 1997.
39. Zatz R. A low cost tail-cuff method for the estimation of mean arterial pressure in conscious rats. Lab Anim Sci 40: 198-201, 1990.