Genetic variations of human neuropsin gene and psychiatric disorders: Polymorphism screening and possible association with bipolar disorder and cognitive functions

Neuropsychopharmacology

Volumn 33, Issue 13, 2008, Pages 3237-3245

  Izumi, Aiko ^a,b   Iijima, Yoshimi ^a   Noguchi, Hiroko ^a   Numakawa, Tadahiro ^a   Okada, Takeya ^a   Hori, Hiroaki ^a   Kato, Tadafumi ^c   Tatsumi, Masahiko ^d,e   Kosuga, Asako ^d   Kamijima, Kunitoshi ^d   Asada, Takashi ^f   Arima, Kunimasa ^g   Saitoh, Osamu ^g   Shiosaka, Sadao ^b   Kunugi, Hiroshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Yokohama Shinryo Clinic   (Japan)

^f UNIVERSITY OF TSUKUBA   (Japan)

^g NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Association study; Bipolar disorder; Intelligence; Memory; Neuropsin; Polymorphism screening

Indexed keywords

LUCIFERASE; NEUROPSIN;

3' UNTRANSLATED REGION; ADULT; ALLELE; ANIMAL CELL; ARTICLE; ATTENTION; BIPOLAR DISORDER; CHROMOSOME 19Q; COGNITION; CONTROLLED STUDY; FEMALE; GENE MAPPING; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTELLIGENCE; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MEMORY; MENTAL CONCENTRATION; MENTAL DISEASE; MOOD DISORDER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; WECHSLER INTELLIGENCE SCALE; WECHSLER MEMORY SCALE;

ADULT; BIPOLAR DISORDER; BRAIN CHEMISTRY; CHROMOSOMES, HUMAN, PAIR 19; COGNITION; DEPRESSIVE DISORDER; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETIC VARIATION; GENOTYPE; HUMANS; INTELLIGENCE; KALLIKREINS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SCHIZOPHRENIA;

EID: 38549112201     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.29     Document Type: Article

References (37)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Press: Washington, DC.
2. Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A et al (2002). A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19. Mol Psychiatry 7: 851-859.
3. Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
4. Chen JM, Férec C, Cooper DN (2006). A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes I: general principles and overview. Hum Genet 120: 1-21.
5. Chen ZL, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T et al (1995). Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci 15: 5088-5097.
6. Daban C, Martinez-Aran A, Torrent C, Tabarés-Seisdedos R, Balanzá-Martínez V, Salazar-Fraile J et al (2006). Specificity of cognitive deficits in bipolar disorder versus schizophrenia. A systematic review. Psychother Psychosom 75: 72-84.
7. Dudbridge F, Koeleman BP, Todd JA, Clayton DG (2000). Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet 66: 2009-2012.
8. Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J et al (2000). Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130.
9. Green MF (2006). Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67: 3-8.
10. Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA (2000). Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem 275: 37397-37406.
11. Komai S, Matsuyama T, Matsumoto K, Kato K, Kobayashi M, Imamura K et al (2000). Neuropsin regulates an early phase of Schaffer-collateral long-term potentiation in the murine hippocampus. Eur J Neurosci 12: 1479-1486.
12. Laifenfeld D, Karry R, Klein E, Ben-Shachar D (2005). Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study. Biol Psychiatry 57: 716-725.
13. Laifenfeld D, Klein E, Ben-Shachar D (2002). Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms. J Neurochem 83: 1054-1064.
14. Li Y, Qian YP, Yu XJ, Wang YQ, Dong DG, Sun W et al (2004). Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory. Mol Biol Evol 21: 2111-2115.
15. Lu ZX, Peng J, Su B (2007). A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory. Hum Mutat 28: 978-984.
16. Macgregor S, Visscher PM, Knott SA, Thomson P, Porteous DJ, Millar JK et al (2004). A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry 9: 1083-1090.
17. Magklara A, Scorilas A, Katsaros D, Massobrio M, Yousef GM, Fracchioli S et al (2001). The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Clin Cancer Res 7: 806-811.
18. Matsumoto-Miyai K, Ninomiya A, Yamasaki H, Tamura H, Nakamura Y, Shiosaka S (2003). NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci 23: 7727-7736.
19. Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (1999). A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain. Eur J Biochem 260: 627-634.
20. Nakamura Y, Tamura H, Horinouchi K, Shiosaka S (2006). Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci 119: 1341-1349.
21. Numakawa T, Yamagishi S, Adachi N, Matsumoto T, Yokomaku D, Yamada M et al (2002). Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. J Biol Chem 277: 6520-6529.
22. Okabe A, Momota Y, Yoshida S, Hirata A, Ito J, Nishino H et al (1996). Kindling induces neuropsin mRNA in the mouse brain. Brain Res 728: 116-120.
23. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M et al (2006). A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry 11: 695-703.
24. Otsubo T, Tanaka K, Koda R, Shinoda J, Sano N, Tanaka S et al (2005). Reliability and validity of Japanese version of the Mini-International Neuropsychiatric Interview. Psychiatry Clin Neurosci 59: 517-526.
25. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN et al (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 93: 105-115.
26. Sairanen M, O'Leary OF, Knuuttila JE, Castrén E (2007). Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience 144: 368-374.
27. Schretlen DJ, Cascella NG, Meyer SM, Kingery LR, Testa SM, Munro CA et al (2007). Neuropsychological functioning in bipolar disorder and schizophrenia. Biol Psychiatry 62: 179-186.
28. Sharma T, Antonova L (2003). Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment. Psychiatr Clin North Am 26: 25-40.
29. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al (1998). The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20): 22-57.
30. Shih RA, Belmonte PL, Zandi PP (2004). A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry 16: 260-283.
31. Shinagawa F, Kobayashi S, Fujita K, Maekawa H (1990). Japanese Wechsler Adult Intelligence Scale-Revised. Nihonbunkakagakusha: Tokyo. (in Japanese).
32. Sugishita M (2001). Japanese Wechsler Memory Scale-Revised. Nihonbunkakagakusha: Tokyo. (in Japanese).
33. Tadokoro K, Hashimoto R, Tatsumi M, Kamijima K, Kunugi H (2004). Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. Neuropsychobiology 50: 206-210.
34. Tamura H, Ishikawa Y, Hino N, Maeda M, Yoshida S, Kaku S et al (2006). Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol 570: 541-551.
35. Wechsler D (1981). Wechsler Adult Intelligence Scale, Revised. Psychological Corporation: New York.
36. Wechsler D (1987). Wechsler Memory Scale Manual, Revised. Psychological Corporation: San Antonio.
37. Yoshida S, Taniguchi M, Hirata A, Shiosaka S (1998). Sequence analysis and expression of human neuropsin cDNA and gene. Gene 213: 9-16.