Antinociceptive and anti-inflammatory effects of saponin and iridoid glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 62, Issue 11-12, 2007, Pages 813-820

  Akkol, Esra Küpeli ^a   Tatli, I Irem ^b   Akdemir, Zeliha S ^b  

^a GAZI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Anti inflammatory activity; Antinociceptive activity; Verbascum pterocalycinum var. mutense

Indexed keywords

VERBASCUM;

EID: 38549083824     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2007-11-1207     Document Type: Article

References (24)

1. Amadio P. Jr., Cummings D. M., and Amadio P. (1993), Nonsteroidal anti-inflammatory drugs. Tailoring therapy to achieve results and avoid toxicity. Postgrad. Med. 93, 73-76.
2. Anam E. M. (2001), Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae). Phytomedicine 8, 24-27.
3. Baytop T. (1999), Therapy with Medicinal Plants in Turkey (Past and Present), 2nd ed. Nobel Tip Kitabevleri Ltd., Istanbul, p. 334.
4. De Young L. M., Kheifets J. B., Ballaron S. J., and Young J. M. (1989), Edema and cell infiltration in the phorbol ester treated mouse ear are temporally separate and can be differently modulated by pharmacologic agents. Agents Activity 26, 335-341.
5. Gamache D. A., Povlishock J. T, and Ellis E. F. (1986), Carrageenan induced brain inflammation. Characterization of the model. J. Neurosurg. 65, 679-685.
6. Garcia-Pastor P., Randazzo A., Gomez-Paloma L., Alcaraz M. J., and Paya M. (1999), Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. J. Pharmacol. Exp. Ther. 289, 166-172.
7. Gepdiremen A., Mshvildadze V., Suleyman H., and Elias R. (2005), Acute anti-inflammatory activity of four saponins isolated from ivy; alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine 12, 440-444.
8. Giner R. M., Villalba M. L., Recio M. C., Manez S., Cerda-Nicolas M., and Rios J. L. (2000), Anti-inflammatory glycoterpenoids from Scrophularia auriculata. Eur. J. Pharmacol. 389, 243-252.
9. Gurbuz I., Ozkan A. M., Yesilada E., and Kutsal O. (2005), Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey). J. Ethnopharmacol. 101, 313-318.
10. Hostettmann K. and Marston A. (1995), Saponins. Cambridge University Press, Cambridge, UK.
11. Huber-Morath A. (1978), In: Flora of Turkey and the East Aegean Islands, Vol. 6 (P. H. Davis, ed.). University Press, Edinburgh, p. 461.
12. Kasahara Y., Hikino H., Tsurufiji S., Watanabe M., and Ohuchi K. (1985), Antiinflammatory actions of ephedrines in acute inflammations. Planta Med. 51, 325-331.
13. Küpeli E., Harput U. S., Varel M., Yesilada E., and Saracoglu I. (2005), Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L. J. Ethnopharmacol. 102, 170-176.
14. K̈peli E., Tatli I.I., Akdemir Z. S., and Yesilada E. (2007), Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoproteins from the flowers of Verbascum lasianthum Boiss. ex Bentham. J. Ethnopharmacol. 110, 498-503.
15. Kulkarni S. K., Mehta A. K., and Kunchandy J. (1986), Anti-inflammatory actions of clonidine, guanfacine and B-HT 920 against various inflammagen-induced acute paw oedema in rats. Arch. Int. Pharmacodyn. Ther. 279, 324-334.
16. Nishizuka Y. (1988), The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 334, 661-665.
17. Okun R., Liddon S. C., and Lasagnal L. (1963), The effect of aggregation, electric shock and adrenergic bloking drugs on inhibition of the "writhing syndrome". J. Pharm. Exp. Ther. 139, 107-109.
18. Paszkiewicz-Gadek A., Grochowska K., and Galasinski W. (1990), Effect of the aqueous extract and saponin fraction from the flowers of Verbascum thapsiforme on protein biosynthesis in a rat liver ribosomal system. Phytother. Res. 4, 177-181.
19. Sezik E., Yesilada E., Honda G., Takaishi Y., Takeda Y., and Tanaka T. (2001), Traditional medicine in Turkey X. Folk medicine in Central Anatolia. J. Ethnopharmacol. 75, 95-115.
20. Szolcsanyi J., Helyes Z., Oroszi G., Nemeth J., and Pinter E. (1998), Release of somatostatin and its role in the mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve. Br. J. Pharmacol. 123, 936-942.
21. Tatli I.I., Akdemir Z. S., Bedir E., and Khan I. A. (2004), Saponin, iridoid, phenylethanoid and monoterpene glycosides from Verbascum pterocalycinum var. mutense. Turkish J. Chem. 28, 111-122.
22. Tokuda H., Konoshima T., Kozuka M., and Kimura R. (1991), Antitumour activities of triterpene saponins from Verbascum songaricum. Oncology 48, 77-80.
23. Turker A. and Camper N. D. (2002), Biological activity of common mullein, a medicinal plant. J. Ethnopharmacol. 82, 117-125.
24. Tuzlaci E. and Erol M. K. (1999), Turkish folk medicinal plants. Part II: Egirdir (Isparta). Fitoterapia 70, 593-610.