Optimization of a DNA vaccine against SARS

DNA and Cell Biology

Volumn 26, Issue 10, 2007, Pages 721-726

  Zakhartchouk, Alexander N ^a   Viswanathan, Sathiyanarayanan ^a,c   Moshynskyy, Igor ^a   Petric, Martin ^b   Babiuk, Lorne A ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; PLASMID VECTOR; CD5 ANTIGEN; MEMBRANE PROTEIN; SIGNAL PEPTIDE; SPIKE GLYCOPROTEIN, CORONAVIRUS; TEGUMENT PROTEIN VP22, BOVINE HERPESVIRUS 1; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BOVINE HERPES VIRUS; CARBOXY TERMINAL SEQUENCE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORONAVIRUS; FEMALE; IMMUNOGENICITY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY PRODUCTION; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; PLASMID; SARS CORONAVIRUS;

BOVINE HERPESVIRUS 1; MUS; SARS CORONAVIRUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD5; FEMALE; HUMANS; IMMUNITY, CELLULAR; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN SORTING SIGNALS; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VACCINES, DNA; VIRAL ENVELOPE PROTEINS; VIRAL STRUCTURAL PROTEINS; VIRAL VACCINES;

EID: 38449107834     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2007.0616     Document Type: Article

References (27)

1. Andre, S., Seed, B., Eberle, J., Schraut, W., Bultmann, A., and Haas, J. (1998). Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J. Virol. 72, 1497-1503.
2. Babcock, G.J., Esshaki, D.J., Thomas, W.D., Jr., and Ambrosino, D.M. (2004). Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J. Virol. 78, 4552-4560.
3. Berry, J.D., Jones, S., Drebot, M.A., Andonov, A., Sabara, M., Yuan, X.Y., Weingartl, H., Fernando, L., Marszal, P., Gren, J., Nicolas, B., Andonova, M., Ranada, F., Gubbins, M.J., Ball, T.B., Kitching, P., Li, Y., Kabani, A., and Plummer, F. (2004). Development and characterisation of neutralising monoclonal antibody to the SARS-coronavirus. J. Virol. Methods 120, 87-96.
4. Buchholz, U.J., Bukreyev, A., Yang, L., Lamirande, E.W., Murphy, B.R., Subbarao, K., and Collins, P.L. (2004). Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proc. Natl. Acad. Sci. USA 101, 9804-9809.
5. Gallagher, T.M., and Buchmeier, M.J. (2001). Coronavirus spike proteins in viral entry and pathogenesis. Virology 279, 371-374.
6. Godet, M., Grosclaude, J., Delmas, B., and Laude, H. (1994). Major receptor-binding and neutralization determinants are located within the same domain of the transmissible gastroenteritis virus (coronavirus) spike protein. J. Virol. 68, 8008-8016.
7. Greenough, T.C., Babcock, G.J., Roberts, A., Hernandez, H.J., Thomas, W.D., Jr., Coccia, J.A., Graziano, R.F., Srinivasan, M., Lowy, I., Finberg, R.W., Subbarao, K., Vogel, L., Somasundaran, M., Luzuriaga, K., Sullivan, J.L., and Ambrosino, D.M. (2005). Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J. Infect. Dis. 91, 507-514.
8. Harms, J.S., Ren, X., Oliveira, S.C., and Splitter, G.A. (2000). Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations. J. Virol. 74, 3301-3312.
9. He, Y., Lu, H., Siddiqui, P., Zhou, Y., and Jiang, S. (2005). Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies. J. Immunol. 174, 4908-4915.
10. Huang, J., Ma, R., and Wu, C. (2006). Immunization with SARSCoV S DNA vaccine generates memory CD4+ and CD8+ T cell immune responses. Vaccine 24, 4905-4913.
11. Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Sullivan, J.L., Luzuriaga, K., Greenough, T.C., Choe, H., and Farzan, M. (2003). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426, 450-454.
12. Oliveira, S.C., Harms, J.S., Afonso, R.R., and Splitter, G.A. (2001). A genetic immunization adjuvant system based on BVP22-antigen fusion. Hum. Gene Ther. 12, 1353-1359.
13. See, R.H., Zakhartchouk, A.N., Petric, M., Lawrence, D.J., Mok, C.P.Y., Hogan, R.J., Rowe, T., Zitzow, L.A., Karunakaran, K.P., Hitt, M.M., Graham, F.L., Prevec, L., Mahony, J.B., Sharon, C., Auperin, T.C., Rini, J.M., Tingle, A.J., Scheifele, D.W., Skowronski, D.M., Patrick D.M., Voss, T.G., Babiuk, L.A., Gauldie, J., Roper, R.L., Brunham, R.C., and Finlay, B.B. (2006). Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. J. Gen. Virol. 87, 641-650.
14. Ter Meulen, J., Bakker, A.B., van den Brink, E.N., Weverling, G.J., Martina, B.E., Haagmans, B.L., Kuiken, T., de Kruif, J., Preiser, W., Spaan, W., Gelderblom, H.R., Goudsmit, J., and Osterhaus, A.D. (2004). Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Lancet 363, 2139-2141.
15. Wang, Z., Yuan, Z., Matsumoto, M., Hengge, U.R., and Chang, Y.F. (2005). Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice. Biochem. Biophys. Res. Commun. 327, 130-135.
16. Weiss, S.R., and Navas-Martin, S. (2005). Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol. Mol. Biol. Rev. 69, 635-664.
17. Wong, S.K., Li, W., Moore, M.J., Choe, H., and Farzan, M.A. (2004). A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 279, 3197-3201.
18. Yang, Z.Y., Kong, W.P., Huang, Y., Roberts, A., Murphy, B.R., Subbarao, K., and Nabel, G.J. (2004). A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428, 561-564.
19. Zakhartchouk, A.N., Liu, Q., Petric, M., and Babiuk, L.A. (2005). Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines. Vaccine 23, 4385-4391.
20. Zakhartchouk, A.N., Reddy, P.S., Baxi, M., Baca-Estrada, M.E., Mehtali, M., Babiuk, L.A., and Tikoo, S.K. (1998). Construction and characterization of E3-deleted bovine adenovirus type 3 expressing full-length and truncated form of bovine herpesvirus type 1 glycoprotein gD. Virology 250, 220-229.
21. Zakhartchouk, A.N., Sharon, C., Satkunarajah, M., Auperin, T., Viswanathan, S., Mutwiri, G., Petric, M., See, R.H., Brunham, R.C., Finlay, B.B., Cameron, C., Kelvin, D.J., Cochrane, A., Rini, J.M., and Babiuk, L.A. (2007). Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine. Vaccine 25, 136-143.
22. Zeng, F., Chow, K.Y., Hon, C.C., Law, K.M., Yip, C.W., Chan, K.H., Peiris, J.S., and Leung, F.C. (2004). Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. Biochem. Biophys. Res. Commun. 315, 1134-1139.
23. Zeng, F., Hon, C.C., Yip, C.W., Law, K.M., Yeung, Y.S., Chan, K.H., Peiris, J.S., and Leung, F.C. (2006). Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit. FEBS Lett. 580, 5612-5620.
24. Zhao, B., Jin, N.Y., Wang, R.L., Zhang, L.S., and Zhang, Y.J. (2006). Immunization of mice with a DNA vaccine based on severe acute respiratory syndrome coronavirus spike protein fragment 1. Viral Immunol. 19, 518-524.
25. Zheng, C., Babiuk, L.A., and van Drunen Little-van den Hurk, S. (2005). Bovine herpesvirus 1 VP22 enhances the efficacy of a DNA vaccine in cattle. J. Virol. 79, 1948-1953.
26. Zheng, C.F., Brownlie, R., Huang, D.Y., Babiuk, L.A., and van Drunen Little-van den Hurk, S. (2006). Intercellular trafficking of the major tegument protein VP22 of bovine herpesvirus-1 and its application to improve a DNA vaccine. Arch. Virol. 151, 985-993.
27. Zhi, Y., Kobinger, G.P., Jordan, H., Suchma, K., Weiss, S.R., Shen, H., Schumer, G., Gao, G., Boyer, J.L., Crystal, R.G., and Wilson, J.M. (2005). Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein. Virology 335, 34-45.