Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment

Journal of Bone and Mineral Research

Volumn 22, Issue 11, 2007, Pages 1759-1765

  Allen, Matthew R ^a   Burr, David B ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Indiana University Purdue University Indianapolis   (United States)

Author keywords

Biomechanics; Bisphosphonates; Osteoporosis; Remodeling; Toughness

Indexed keywords

ALENDRONIC ACID; SODIUM CHLORIDE; BONE DENSITY CONSERVATION AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE INJURY; BONE TURNOVER; CONTROLLED STUDY; DENSITOMETRY; DOG; DRUG DOSE COMPARISON; ENERGY ABSORPTION; FEMALE; LUMBAR VERTEBRA; MORPHOMETRICS; NONHUMAN; OSTEOPOROSIS; PAGET BONE DISEASE; RIGIDITY; TRABECULAR BONE; TREATMENT DURATION; ANIMAL; CAT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; FRACTURE; HARDNESS; INJURY; RADIOGRAPHY;

ALENDRONATE; ANIMALS; BIOMECHANICS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CATS; FEMALE; FRACTURES, BONE; HARDNESS; LUMBAR VERTEBRAE;

EID: 38449101476     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070720     Document Type: Article

References (26)

1. Frost HM 1960 Presence of microscopic cracks in vivo in bone. Henry Ford Med Bull 8:417-423.
2. Schaffler MB, Choi K, Milgrom C 1995 Aging and matrix microdamage accumulation in human compact bone. Bone 17:521-525.
3. Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH 1997 Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12:6-15.
4. Donahue SW, Galley SA 2006 Microdamage in bone: Implications for fracture, repair, remodeling, and adaptation. Crit Rev Biomed Eng 34:215-271.
5. Burr DB, Martin RB, Schaffler MB, Radin EL 1985 Bone remodeling in response to in vivo fatigue microdamage. J Biomech 18:189-200.
6. Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB 1998 Intracortical remodeling in adult rat long bones after fatigue loading. Bone 23:275-281.
7. Mori S, Burr DB 1993 Increased intracortical remodeling following fatigue damage. Bone 14:103-109.
8. Parfitt AM 1993 Bone age, mineral density, and fatigue damage. Calcif Tissue Int 53(Suppl 1):S82-S85.
9. Norman TL, Wang Z 1997 Microdamage of human cortical bone: Incidence and morphology in long bones. Bone 20:375-379.
10. Wasserman N, Yerramshetty J, Akkus O 2005 Microcracks colocalize within highly mineralized regions of cortical bone tissue. Eur J Morphol 42:43-51.
11. Bone HG, Hosking D, Devogelaer J-P, Tucci JR, Emkey RD, Tonino RP, Rodriguez-Portales JA, Downs RW, Gupta J, Santora AC, Liberman UA, the Alendronate Phase III Osteoporosis Treatment Study Group 2004 Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 350:1189-1199.
12. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE 1996 Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348:1535-1541.
13. Cummings SR, Black DM, Thompson DE, Applegate WB, Barrett-Connor E, Musliner TA, Palermo L, Prineas R, Rubin SM, Scott JC, Vogt T, Wallace R, Yates AJ, LaCroix AZ 1998 Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: Results from the Fracture Intervention Trial. JAMA 280:2077-2082.
14. Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB 2000 Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613-620.
15. Mashiba T, Turner CH, Hirano T, Forwood MR, Johnston CC, Burr DB 2001 Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone 28:524-531.
16. Komatsubara S, Mori S, Mashiba T, Li J, Nonaka K, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H 2004 Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib. J Bone Miner Res 19:999-1005.
17. Komatsubara S, Mori S, Mashiba T, Ito M, Li J, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H 2003 Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. J Bone Miner Res 18:512-520.
18. Allen MR, Iwata K, Phipps R, Burr DB 2006 Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate. Bone 39:872-879.
19. Allen MR, Burr DB 2007 Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs. Osteoporos Int (in press).
20. Burr DB, Stafford T 1990 Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop 260:305-308.
21. Parfitt A, Drezner M, Glorieux F, Kanis J, Malluche H, Meunier P, Ott S, Recker R 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610.
22. Huja SS, Hasan MS, Pidaparti R, Turner CH, Garetto LP, Burr DB 1999 Development of a fluorescent light technique for evaluating microdamage in bone subjected to fatigue loading. J Biomech 32:1243-1249.
23. Gineyts E, Allen MR, Burr DB, Delmas PD 2006 Effects of antiresorptive therapy on the bone tissue concentration of enzymatic mature collagen crosslinks and pentosidine. J Bone Miner Res 21;S1:M344.
24. Allen MR, Burr DB 2007 Mineralization, microdamage, and matrix: How bisphosphonates influence material properties of bone. BoneKEy 4:49-60.
25. Hernandez C, Keaveny T 2006 A biomechanical perspective on bone quality. Bone 39:1173-1181.
26. Stepan JJ, Burr DB, Pavo I, Sipos A, Michalska D, Li J, Fahrleitner-Pammer A, Petto H, Westmore M, Michalsky D, Sato M, Dobnig H 2007 Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women. Bone 41:378-385.