A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Journal of Antibiotics

Volumn 60, Issue 7, 2007, Pages 459-462

  Ueda, Jun Ya ^b   Togashi, Takushi ^b   Matukura, Susumu ^b   Nagai, Aya ^b   Nakashima, Takuji ^c   Komaki, Hisayuki ^c   Anzai, Kozue ^c   Harayama, Shigeaki ^c   Doi, Takayuki ^d   Takahashi, Takashi ^d   Natsume, Tohru ^a   Kisu, Yasutomo ^a   Goshima, Naoki ^a   Nomura, Nobuo ^a   Takagi, Motoki ^b   Shin ya, Kazuo ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b Japan Biological Information Research Center   (Japan)

^c NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION   (Japan)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

JBIR 02; Leptomycin; Nuclear transport; Piericidin; Streptomyces sp.

Indexed keywords

ANTIBIOTIC AGENT; BETA ARRESTIN; IT 143B; JBIR 02; PIERICIDIN; PIERICIDIN A 1; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; JBIR 02 COMPOUND; JBIR-02 COMPOUND; PIERICIDIN A; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; ENZYME ISOLATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MYCELIUM; NONHUMAN; NUCLEAR EXPORT SIGNAL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPECTROSCOPY; STREPTOMYCES; ACTIVE TRANSPORT; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT;

STREPTOMYCES SP.;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTI-BACTERIAL AGENTS; HELA CELLS; HUMANS; PYRIDINES; PYRIDONES; SPECTRUM ANALYSIS; STREPTOMYCES;

EID: 38449099283     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.59     Document Type: Article

References (10)

1. Ferguson SS, Downey WE 3rd, Colapietro AM, Barak LS, Menard L, Caron MG. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271: 363-366 (1996)
2. Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. β-Arrestin: a protein that regulates β-adrenergic receptor function. Science 248: 1547-1550 (1990)
3. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. β-Arrestins and cell signaling. Annu Rev Physiol 69: 483-510 (2007)
4. Sacks DB. The role of scaffold proteins in MEK/ERK signalling. Biochem Soc Trans 34: 833-836 (2006)
5. Buchanan FG, DuBois RN. Related emerging roles of beta-arrestins. Cell Cycle 5: 2060-2063 (2006)
6. Schnermann MJ, Boger DL. Total synthesis of piericidin A1 and B1. J Am Chem Soc 127: 15704-15705 (2005). See also their Supporting Information.
7. Urakawa A, Sasaki T, Yoshida K, Otani T. IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp. J Antibiot 49: 1052-1055 (1996)
8. Kominato K, Watanabe Y, Hirano S, Kioka T, Terasawa T, Yoshioka T, Okamura K, Tone H. Mer-A2026A and B, novel piericidins with vasodilating effect. II. Physico-chemical properties and chemical structures. J Antibiot 48: 103-105 (1995)
9. Hamamoto T, Gunji S, Tsuji H, Beppu T. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. J Antibiot 36: 639-645 (1983)
10. Yashiroda Y, Yoshida M. Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs. Curr Med Chem 10: 741-748 (2003)