Influence of extracellular and cytoplasmic domains of M2 ion channel of influenza A virus on its activity

Acta Virologica

Volumn 51, Issue 2, 2007, Pages 119-124

  Kollerova E ^a   Betakova T ^a  

^a INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Influenza A virus; Ion channel; M2 protein; Mutational analysis

Indexed keywords

ION CHANNEL; PROTEIN M2; M2 PROTEIN, INFLUENZA A VIRUS; MATRIX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; MUTATIONAL ANALYSIS; NONHUMAN; PH MEASUREMENT; PLASMID; PROTEIN EXPRESSION; SUBSTITUTION REACTION; VACCINIA; WESTERN BLOTTING; CELL LINE; CHEMISTRY; GENETICS; HELA CELL; METABOLISM; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION;

INFLUENZA A VIRUS; INFLUENZA B VIRUS;

CELL LINE; DNA MUTATIONAL ANALYSIS; HELA CELLS; HUMANS; INFLUENZA A VIRUS; ION CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL MATRIX PROTEINS;

EID: 38449087665     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Betakova T, Ciampor F, Hay AJ (2005): Influence of residue 44 on the activity of the M2 proton channel of influenza A virus. J. Gen. Virol. 86, 181-184. (Pubitemid 40081164)
2. Betáková T, Kollerová E (2006): pH modulating activity of ion channels of influenza A, B, and C viruses. Acta Virol. 50, 187-193. (Pubitemid 46030061)
3. Chizhmakov IV, Geraghty FM, Ogden DC, Hayhurst A, Antoniou M, Hay AJ (1996): Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukemia cells. J. Phiosiol. 494, 329-336. (Pubitemid 26318773)
4. Chizhmakov IV, Ogden DC, Geraghty FM, Hayhurst A, Skinner A, Betakova T, Hay AJ (2003): Differences in conductance of M2 proton channels of two influenza viruses at low and high pH. J. Physiol. 546, 427-438 (Pubitemid 36175978)
5. Ciampor F, Bayley PM, Nermut MV, Hirst EM, Sugrue RJ, Hay AJ (1992): Evidence that the amantadine-induced M2- mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans- Golgi compartment. Virology 188, 14-24.
6. Czabotar PE, Martin SR, Hay AJ (2004): Studies of structural changes in the M2 proton channel of influenza A virus by trypthophan fluorescence. Virus Research 99, 57-61.
7. Grambas S, Bennet MS, Hay AJ (1992): Influence of amantadine resistance mutations on the pH encoutered during transport and its regulation by the M2 protein. Virology 191, 541-549. (Pubitemid 23022458)
8. Grambas S, Hay AJ (1992): Maturation of influenza A virus hemagglutinin-Estimates of the pH encountered during transport and its regulation by the M2 protein. Virology 190, 11-18.
9. Hay AJ, Wolstenholme AJ, Skehel JJ, Smith MH (1985): The molecular basis of the specific anti-influenza action of amantadine. EMBO J. 4, 3021-3024.
10. von Heijne GV (1986): The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology. EMBO J. 5, 3021-3027.
11. Helenius A (1992): Unpacking the incoming influenza virus. Cell 69, 577-578.
12. Iwatsuki-Horimoto K, Horimoto T, Noda T, Kiso M, Maeda J, Watanabe S, Muramoto Y, Fujii K, Kawaoka Y (2006): The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. J. Virol. 80, 5233-5240. (Pubitemid 43752768)
13. Kollerova E, Betáková T (2006): Influenza viruses and their ion channels. Acta Virol. 50, 7-16. (Pubitemid 47434332)
14. Lamb RA, Zebedee SL, Richardson CD (1985): Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40, 627-633.
15. Liu W, Li H, Chen YH (2003): N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication. FEMS Immunol. Med. Microbiol. 35, 141-146. (Pubitemid 36298936)
16. Martin K, Helenius A (1991): Nuclear transport of influenza virus ribonucleoproteins: The viral matrix protein (M1) promotes export and inhibits import. Cell 67, 117-130. (Pubitemid 121001429)
17. McCown MF, Pekosz A (2006): Distinct domains of the influenza A virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J. Virol. 80, 8178-8189.
18. Mould JA, Drury JE, Frings SM, Kaupp UB, Pekosz A, Lamb RA Pinto LH (2000): Permeation and activation of the M2 ion channel of influenza A virus. J. Biol. Chem. 275, 31038-31050. (Pubitemid 30757762)
19. Okada A, Miura T, Takeuchi H (2001): Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza A virus. Biochemistry 40, 6053-6060. (Pubitemid 32466308)
20. Park EK, Castrucci MR, Portner A, Kawaoka Y (1998): The M2 ectodomain is important for its incorporation into influenza A virions. J. Virol. 72, 2449-2455. (Pubitemid 28100806)
21. Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy M, Lear JD, Lamb RA, DeGrado WF (1997): A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc. Natl. Acad. Sci. USA 4, 11301-21136 (Pubitemid 27450993)
22. Sugrue RJ, Belshe RB, Hay AJ (1990): Palmitoylation of the influenza A virus M2 protein. Virology 179, 51-56.
23. Sugrue RJ, Hay AJ (1991): Structural characteristics of the M2 protein of influenza A viruses: Evidence that it forms a tetrameric channel. Virology 180, 617-624.
24. Tobler K, Kelly ML, Pinto LH, Lamb RA (1999): Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus. J. Virol. 73, 9695-9701.
25. Wang C, Lamb RA, Pinto LH (1995): Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue. Biophys J. 69, 1363-1371.
26. 2-terminal region. Mol. Cell. Biol. 6, 4317-4328.
27. Williams MA, Lamb RA (1988): Polylactosaminoglycan modification of small integral membrane glycoprotein, influenza B virus NB. Mol. Cell. Biol. 8, 1186-1196.
28. Zebedee SL, Lamb RA (1988): Influenza A virus M2 protein: Monoclonal antibody restriction of growth and detection of M2 in virions. J. Virol. 62, 2762-2772.