Targeting osteoporosis and rheumatoid arthritis by active vaccination against RANKL

Advances in Experimental Medicine and Biology

Volumn 602, Issue , 2007, Pages 135-142

  Spohn, Gunther ^a   Bachmann, Martin F ^a  

^a CYTOS BIOTECHNOLOGY AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BACTERIOPHAGE QBETA RANKL VACCINE; DEOXYPYRIDINOLINE; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PEPTIDE ANTIBODY; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; UNCLASSIFIED DRUG; VACCINE;

ACTIVE IMMUNIZATION; ANTIBODY RESPONSE; ANTIBODY TITER; BACTERIOPHAGE; BONE DENSITY; CONFERENCE PAPER; COST BENEFIT ANALYSIS; DISEASE MODEL; DRUG COST; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; LEWIS RAT; MOUSE STRAIN; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; VIRUS LIKE AGENT; ANIMAL; ARTICLE; ECONOMICS; IMMUNOLOGY; METABOLISM; MOUSE; VACCINATION;

ANIMALS; ARTHRITIS, RHEUMATOID; MICE; OSTEOPOROSIS; RANK LIGAND; VACCINATION; VACCINES;

EID: 38449086622     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-72009-8_17     Document Type: Conference Paper

References (21)

1. Ashcroft, A.J., S.M. Cruickshank, P.I. Croucher, M.J. Perry, S. Rollinson, J.M. Lippitt, J.A. Child, C. Dunstan, P.J. Felsburg, G.J. Morgan, and S.R. Carding. 2003. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19(6): 849-861.
2. Bachmann, M.F., and M.R. Dyer. 2004. Therapeutic vaccination for chronic diseases: a new class of drugs in sight. Nat Rev Drug Discov 3(1): 81-88.
3. Bachmann, M.F., B.R. Wong, R. Josien, R.M. Steinman, A. Oxenius, and Y. Choi. 1999. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med 189(7): 1025-1031.
4. Bekker, P.J., D.L. Holloway, A.S. Rasmussen, R. Murphy, S.W. Martin, P.T. Leese, G.B. Holmes, C.R. Dunstan, and A.M. DePaoli. 2004. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 19(7): 1059-1066.
5. Chackerian, B., D.R. Lowy, and J.T. Schiller. 2001. Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J Clin Invest 108(3): 415-423.
6. De Klerck, B., I. Carpentier, R.J. Lories, Y. Habraken, J. Piette, G. Carmeliet, R. Beyaert, A. Billiau, and P. Matthys. 2004. Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knockout mice as related to increased splenic CD11b+ myelopoiesis. Arthritis Res Ther 6(3): R220-R231.
7. Gravallese, E.M., C. Manning, A. Tsay, A. Naito, C. Pan, E. Amento, and S.R. Goldring. 2000. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43(2): 250-258.
8. Jegerlehner, A., A. Tissot, F. Lechner, P. Sebbel, I. Erdmann, T. Kundig, T. Bachi, T. Storni, G. Jennings, P. Pumpens, W.A. Renner, and M.F. Bachmann. 2002. A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine 20(25-26): 3104-3112.
9. Kong, Y.Y., U. Feige, I. Sarosi, B. Bolon, A. Tafuri, S. Morony, C. Capparelli, J. Li, R. Elliott, S. McCabe, T. Wong, G. Campagnuolo, E. Moran, E.R. Bogoch, G. Van, L.T. Nguyen, P.S. Ohashi, D.L. Lacey, E. Fish, W.J. Boyle, and J.M. Penninger. 1999. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402(6759): 304-309.
10. Kong, Y.Y., H. Yoshida, I. Sarosi, H.L. Tan, E. Timms, C. Capparelli, S. Morony, A.J. Oliveira-dos-Santos, G. Van, A. Itie, W. Khoo, A. Wakeham, C.R. Dunstan, D.L. Lacey, T.W. Mak, W.J. Boyle, and J.M. Penninger. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397(6717): 315-323.
11. Lawrence, R.C., C.G. Helmick, F.C. Arnett, R.A. Deyo, D.T. Felson, E.H. Giannini, S.P. Heyse, R. Hirsch, M.C. Hochberg, G.G. Hunder, M.H. Liang, S.R. Pillemer, V.D. Steen, and F. Wolfe. 1998. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41(5): 778-799.
12. Lechner, F., A. Jegerlehner, A.C. Tissot, P. Maurer, P. Sebbel, W.A. Renner, G.T. Jennings, and M.F. Bachmann. 2002. Virus-like particles as a modular system for novel vaccines. Intervirology 45(4-6): 212-217.
13. Li, P., E.M. Schwarz, R.J. O'Keefe, L. Ma, B.F. Boyce, and L. Xing. 2004. RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res 19(2): 207-213.
14. Li, P., E.M. Schwarz, R.J. O'Keefe, L. Ma, R.J. Looney, C.T. Ritchlin, B.F. Boyce, and L. Xing. 2004. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum 50(1): 265-276.
15. McClung, M.R., E.M. Lewiecki, S.B. Cohen, M.A. Bolognese, G.C. Woodson, A.H. Moffett, M. Peacock, P.D. Miller, S.N. Lederman, C.H. Chesnut, D. Lain, A.J. Kivitz, D.L. Holloway, C. Zhang, M.C. Peterson, and P.J. Bekker. 2006. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354(8): 821-831.
16. Pettit, A.R., H. Ji, D. von Stechow, R. Muller, S.R. Goldring, Y. Choi, C. Benoist, and E.M. Gravallese. 2001. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159(5): 1689-1699.
17. Riggs, B.L., S. Khosla, and L.J. Melton III. 2002. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23(3): 279-302.
18. Seshasayee, D., H. Wang, W.P. Lee, P. Gribling, J. Ross, N. Van Bruggen, R. Carano, and I.S. Grewal. 2004. A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response. J Biol Chem 279(29): 30202-30209.
19. Spohn, G., K. Schwarz, P. Maurer, H. Illges, N. Rajasekaran, Y. Choi, G.T. Jennings, and M.F. Bachmann. 2005. Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles. J Immunol 175(9): 6211-6218.
20. Takayanagi, H., H. Iizuka, T. Juji, T. Nakagawa, A. Yamamoto, T. Miyazaki, Y. Koshihara, H. Oda, K. Nakamura, and S. Tanaka. 2000. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis, Arthritis Rheum 43(2): 259-269.
21. Xing, L., E.M. Schwarz, and B.F. Boyce. 2005. Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev 208: 19-29.