Mixtures of chiral monodentate phosphites, phosphonites and phosphines as ligands in Rh-catalyzed hydrogenation of N-acyl enamines: Extension of the combinatorial approach

Tetrahedron Asymmetry

Volumn 15, Issue 14, 2004, Pages 2165-2167

  Reetz, Manfred T ^a   Mehler, Gerlinde ^a   Meiswinkel, Andreas ^a  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENAMINE; LIGAND; METAL; PHOSPHITE; TRANSITION ELEMENT;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOSELECTIVITY; EQUILIBRIUM CONSTANT; HYDROGENATION; PRIORITY JOURNAL;

EID: 3843149637     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2004.04.038     Document Type: Article

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39. 4 (0.5 mL) in dichloromethane and stirred for 5 min at room temperature. Then a 0.112 M solution of substrate 4a in dichloromethane (9 mL) is added. Vacuum is applied three times until the solvent begins to evaporate gently and then hydrogen is introduced. Hydrogenation is carried out at 1.3 bar for 20 h. Following dilution, conversion is determined by NMR spectroscopy. To determine the ee values, about 1.5 mL of the reaction solution can be passed through a small amount of silica gel prior to the GC analysis