Diffusion behaviors of drugs in thermosensitive in situ gels

Yaoxue Xuebao

Volumn 39, Issue 3, 2004, Pages 232-235

  Wei, Gang ^a   Lu, Wei Yue ^a   Zheng, Jun Min ^b  

^a FUDAN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Diffusion; Poloxamer; Thermosensitive in situ gel

Indexed keywords

HYALURONIC ACID; POLOXAMER; PROPRANOLOL DERIVATIVE; SALBUTAMOL SULFATE; TIMOLOL MALEATE; DRUG CARRIER; PROPRANOLOL; SALBUTAMOL; SURFACTANT; TIMOLOL;

ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; DIFFUSION; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; HEAT SENSITIVITY; MICELLE; STATISTICAL SIGNIFICANCE; VISCOSITY; CHEMISTRY; DELAYED RELEASE FORMULATION; GEL;

ALBUTEROL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; POLOXAMER; PROPRANOLOL; SURFACE-ACTIVE AGENTS; TIMOLOL;

EID: 3843146317     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Jeong B, Kim SW, Bae YH. Thermosensitive sol-gel reversible hydrogels [J]. Adv Drug Deliv Rev, 2002,54(1):37-51.
2. Hatefi A, Amsden B. Biodegradable injectable in situ forming drug delivery systems [J]. J Controlled Release, 2002,80(1):9-28.
3. Carfors J, Edsman K, Petersson R, et al. Rheological evaluation of Gelrite® in situ gels for ophthalmic use [J]. Eur J Pharm Sci, 1998,6(2):113-119.
4. Srividya B, Cardoza RM, Amin PD. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system [J]. J Controlled Release, 2001,73(2):205-211.
5. Wei G, Xu H, Ding PT, et al. Thermosetting gels with modulated gelation temperature for ophthalmic use: rheological and gamma scintigraphic studies [J]. J Controlled Release, 2002,83(1):65-74.
6. Bohorquez M, Koch C, Trygstad T, et al. A study of the temperature-dependent micellization of Pluronic F127 [J]. J colloid Interface Sci, 1999,216(1):34-40.
7. Paavola A, Yliruusi J, Rosenberg P. Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels [J]. J Controlled Release, 1998,52(1-2):169-178.
8. Yun MO, Choi HG, Jung JH, et al. Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement [J]. Int J Pharm, 1999,189(2):137-145.
9. Shin SC, Cho CW, Oh IJ. Effect of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins [J]. Int J Pharm, 2001,222(2):199-203.
10. Wei G, Xu H, Ma Y, et al. Effect of pH on the permeability of timolol maleate across isolated rabbit cornea [J]. Acta Pharm Sin, 2001,36(9):707-710.
11. Upadrashta SM, Häglund BO, Sundelöf LO. Diffusion and concentration profiles of drugs in gels [J]. J Pharm Sci, 1993,82(11):1094-1098.
12. Sjoberg H, Bergman R, Sundelöf LO. A new method for diffusion measurement in polymeric films based on a standard sheet concept [J]. Pharm Res, 1996,13(12):1871-1874.
13. French DL, Häglund BO, Himmelstein KJ, Mauger JW. Controlled release of substituted benzoic and naphthoic acids using Carbopol® gels: measurement of drug concentration profiles and correlation to release rate kinetics [J]. Pharm Res, 1995,12(10):1513-1520.
14. Lu GW, Jun HW. Diffusion studies of methotrexate in carbopol and poloxamer gels [J]. Int J Pharm, 1998,160 (1):1-9.
15. Shu H, Jun HW. Physicochemical and release studies of naproxen in poloxamer gels [J]. Int J Pharm, 1996,129(1):3-20.
16. Chi SC, Jun HW. Release rates of ketoprofen from poloxamer gels in a membraneless diffusion cell [J]. J Pharm Sci, 1991,80(3):280-283.