Three step to cancer: How phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 2, 2004, Pages 101-104

  Idriss, Haitham T ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apoptosis; Cancer cells; Multidrug resistance; Phosphorylation; Tubulin modifications; Tubulin tyrosine ligase

Indexed keywords

ANTINEOPLASTIC AGENT; GLYCOPROTEIN P; LIGASE; PROTEIN KINASE C; TUBULIN; TUBULIN TYROSINE LIGASE; UNCLASSIFIED DRUG; PEPTIDE SYNTHASE;

APOPTOSIS; BINDING AFFINITY; BREAST ADENOCARCINOMA; CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CELL SURVIVAL; CELL TRANSFORMATION; HUMAN; MICROTUBULE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVIEW; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

APOPTOSIS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, MULTIPLE; HUMANS; MICROTUBULES; NEOPLASMS; P-GLYCOPROTEIN; PEPTIDE SYNTHASES; PHOSPHORYLATION; TUBULIN;

EID: 3843133014     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Alnemri ES (1997) Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases. J Cell Biochem 64:33-42
2. Banerjee A (2002) Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. Biochem Biophys Res Commun 293:598-601
3. Banerjee A, Kasmala LT (1998) Differential assembly kinetics of alpha-tubulin isoforms in the presence of paclitaxel. Biochem Biophys Res Commun 245:349-351
4. Chang W, Webster DR, Salam AA, Gruber D, Prasad A, Eiserich JP, Bulinski JC (2002) Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation. J Biol Chem 277:30690-30698
5. Chen WY, Yang YM, Chuang NN (2002) Selective enhanced phosphorylation of shrimp beta-tubulin by PKC-delta with PEP (taxol), a synthetic peptide encoding the taxol binding region. J Exp Zool 292:376-383
6. Eiserich JP, Estevez AG, Bamberg TV, Ye YZ, Chumley PH, Beckman JS, Freeman BA (1999) Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. Proc Natl Acad Sci U S A 96:6365-6370
7. Idriss HT (2000a) Man to trypanosome: the α-tubulin tyrosination/detyrosination cycle revisited. Cell Motil Cytoskeleton 45:173-184
8. Idriss HT (2000b) Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of α-tubulin tyrosination. Cell Motil Cytoskeleton 46:1-5
9. Idriss HT (2000c) Do TNF α insensitive cancer cells escape α-tubulin nitro-tyrosination? Nitric Oxide 4:1-3
10. Idriss H, Urquidi V, Basavappa S (2000a) Selective regulation of P-glycoprotein's ATPase and anion efflux activities with PKC α and PKC ε in Sf9 cells. Cancer Chemother Pharmacol46:287-292
11. - channels. J Physiol 524:629-636
12. Ischiropoulos H (1998) Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys 356:1-11
13. Khan IA, Luduena RF (1996) Phosphorylation of betaIII-tubulin. Biochemistry 35:3704-3711
14. Khan IA, Luduena RF (2003) Different effects of vinblastine on the polymerization of isotypically purified tubulins from bovine brain. Invest New Drugs 21:3-13
15. Mialhe A, Lafanechere L, Treilleux I, Peloux N, Dumontet C, Bremond A, Panh MH, Payan R, Wehland J, Margolis RL, Job D (2001) Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res 61:5024-5027
16. Nicotera P (2002) Apoptosis and age-related disorders: role of caspase-dependent and caspase-independent pathways. Toxicol Lett 127:189-195
17. O'Brian CA, Ward NE, Stewart JR, Chu F (2001) Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer - an evolving story. Cancer Metastasis Rev 20:95-100
18. Ranganathan S, Dexter DW, Benetatos CA, Chapman AE, Tew KD, Hudes GR (1996) Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance. Cancer Res 56:2584-2589
19. Rao S, Aberg F, Nieves E, Band Horwitz S, Orr GA (2001) Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines. Biochemistry 40:2096-2103
20. Sanchez I, Mahlke C, Yuan J (2003) Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 421:373-379
21. Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E (2001) The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proc Natl Acad Sci U S A 98:5312-5316
22. Yoshida N, Haga K, Haga T (2003) Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin. Eur J Biochem 270:1154-1163