mRNA Expression alteration of two-pore potassium channels in the brain of β-amyloid peptide25-35-induced memory impaired rats

Yaoxue Xuebao

Volumn 38, Issue 10, 2003, Pages 721-724

  Pan, Ya Ping ^a   Xu, Xiang Hua ^a   Wang, Xiao Liang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Amyloid peptide; RT PCR; Two pore potassium channel

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (25 35); AMYLOID BETA-PROTEIN (25-35); KCNK10 PROTEIN, RAT; KCNK4 PROTEIN, RAT; MESSENGER RNA; PEPTIDE FRAGMENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN CORTEX; CHEMICALLY INDUCED DISORDER; GENETICS; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY DISORDER; METABOLISM; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PROTEIN; ANIMALS; CEREBRAL CORTEX; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; PEPTIDE FRAGMENTS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 3843120102     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Hirakura Y, Satoh Y, Hirashima N, et al. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment beta 25-35 requires aggregation and beta-sheet formation[J]. Biochem Mol Biol Int, 1998, 46(4): 787-794.
2. + channels[J]. Ann N Y Acad Sci, 1999, 868: 233-285.
3. Alkon DL. Ionic conductance determinants of synaptic memory nets and their implications for Alzheimer's disease [J]. J Neurosci Res, 1999, 58(1): 24-32.
4. Medhurst AD, Rennie G, Chapman CG, et al. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and eriphery[J]. Brain Res Mol Brain Res, 2001, 86(1-2): 101-114.
5. + channel[J]. Chin Pharmacol Bull, 2002, 18(4): 369-373.
6. Tong XY, Wang XL. The expression levels of GIRK1 and IRK1 in memory deficit rats[J] . Acta Pharm Sin, 2001, 36(7): 488-492.
7. Yamaguchi Y, Kawashima S. Effects of amyloid-beta-(25-35) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat[J]. Eur J Pharmacol, 2001, 412(3): 265-272.
8. Lauritzen I, Blondeau N, Heurteaux C, et al. Polyunsaturated fatty acids are potent neuroprotectors[J]. EMBO J, 2000, 19(8): 1784-1793.
9. + channel[J]. J Biol Chem, 1999, 274(3): 1381-1387.
10. Maingret F, Patel AJ, Lesage F, et al. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel [J] . J Biol Chem, 1999, 274(38): 26691 -26696.
11. Maingret F, Patel AJ, Lesage F, et al. Lysophospholipids open the two-pore domain mechano-gated K (+) channels TREK-1 and TRAAK[J]. J Biol Chem, 2000, 275(14): 10128-10133.