First enantioselective synthesis of the novel antiinfective TAN-1057A via its aminomethyl-substituted dihydropyrimidinone heterocycle

Tetrahedron

Volumn 60, Issue 35, 2004, Pages 7579-7589

  Belov, Vladimir N ^a,b   Brands, Michael ^c   Raddatz, Siegfried ^d   Krüger, Jochen ^d   Nikolskaya, Sofia ^a,e   Sokolov, Viktor ^a,e   De Meijere, Armin ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b KAdemCustomChem GmbH   (Germany)

^c BAYER CORPORATION   (United States)

^d BAYER PHARMA AG   (Germany)

^e ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

Amino acids; Chiral pool; Natural products; Nitrogen heterocycles; Total synthesis

Indexed keywords

ANTIINFECTIVE AGENT; CARBONYL DERIVATIVE; FLUOROPHOSPHATE; HETEROCYCLIC COMPOUND; HOMOARGININE; N,N DIMETHYLACETAMIDE; O (7 AZABENZOTRIAZOL 1 YL) N,N,N',N' TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; PYRIMIDINONE DERIVATIVE; TAN 1057 A; UNCLASSIFIED DRUG;

ARTICLE; COLUMN CHROMATOGRAPHY; CYCLIZATION; DEGRADATION; DIASTEREOISOMER; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HYDROGENOLYSIS; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SUBSTITUTION REACTION;

EID: 3843108171     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.06.034     Document Type: Article

References (29)

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