Functional topology of the mossy fibre-granule cell-Purkinje cell system revealed by imaging of intrinsic fluorescence in mouse cerebellum

European Journal of Neuroscience

Volumn 20, Issue 3, 2004, Pages 740-748

  Coutinho, V ^a   Mutoh, H ^a   Knopfel T ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

In vitro; Mitochondria; Optical imaging; Parallel fibres; Purkinje cell

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CARBOXYLATE ETHYL ESTER; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BICUCULLINE; CHROMENE DERIVATIVE; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; PICROTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLUE LIGHT; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL STIMULATION; CEREBELLUM; CONTROLLED STUDY; ELECTROSTIMULATION; EXCITATION; FLUORESCENCE; GRANULE CELL; ILLUMINATION; IMAGING; MEMORY CONSOLIDATION; METABOLISM; MOSSY FIBER; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RECEPTOR BLOCKING; SPIKE WAVE; WHITE MATTER;

2-AMINO-5-PHOSPHONOVALERATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM; CEREBELLUM; CHROMONES; DIAGNOSTIC IMAGING; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENCE; GABA ANTAGONISTS; METHOXYHYDROXYPHENYLGLYCOL; MICE; MICE, INBRED ICR; NERVE FIBERS; NEURONS; PICROTOXIN; QUINOXALINES; TIME FACTORS;

EID: 3843051493     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2004.03533.x     Document Type: Article

References (40)

1. Batchelor, A.M., Knöpfel, T., Gasparini, F. & Garthwaite, J. (1997) Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices. Neuropharmacology, 36, 401-403.
2. Bessey, O.A., Bates, C.J. & Love, R.H. (1949) The fluorimetric measurement of the nucleotides of riboflavin and their concentration in tissues. J. Biol. Chem., 180, 755-769.
3. Billups, B. & Forsythe, I.D. (2002) Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses. J. Neurosci., 22, 5840-5847.
4. Bower, J.M. (2002) The organization of cerebellar cortical circuitry revisited: implications for function. Ann. N Y Acad. Sci., 978, 135-155.
5. Bower, J.M. & Woolston, D.C. (1983) Congruence of spatial organization of tactile projections to granule cell and Purkinje cell layers of cerebellar hemispheres of the albino rat: vertical organization of cerebellar cortex. J. Neurophysiol., 49, 745-766.
6. Braitenberg, V. & Atwood, R.P. (1958) Morphological observations on the cerebellar cortex. J. Comp Neurol., 109, 1-33.
7. Casado, M., Isope, P. & Ascher, P. (2002) Involvement of presynaptic N-methyl-D-aspartate receptors in cerebellar long-term depression. Neuron, 33, 123-130.
8. Chance, B. (1991) Optical method. Annu. Rev. Biophysics Biophys. Chem., 20, 1-28.
9. Chance, B., Schoener, B., Oshino, R., Itshak, F. & Nakase, Y. (1979) Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. J. Biol. Chem., 254, 4764-4771.
10. Chen, G., Hanson, C.L. & Ebner, T.J. (1998) Optical responses evoked by cerebellar surface stimulation in vivo using neutral red. Neuroscience, 84, 645-668.
11. Cohen, L.B., Keynes, R.D. & Hille, B. (1968) Light scattering and birefringence changes during nerve activity. Nature, 218, 438-441.
12. Cohen, D. & Yarom, Y. (1998) Patches of synchronized activity in the cerebellar cortex evoked by mossy-fiber stimulation: questioning the role of parallel fibers. Proc. Natl Acad. Sci. USA, 95, 15032-15036.
13. D'Angelo, E., De Filippi, G., Rossi, P. & Taglietti, V. (1995) Synaptic excitation of individual rat cerebellar granule cells in situ. Evidence for the role of NMDA receptors. J. Physiol. (Lond.), 484, 397-413.
14. Eccles, J.C., Sasaki, K. & Strata, P. (1966) The profiles of physiological events produced by a parallel fibre volley in the cerebellar cortex. Exp. Brain Res., 2, 18-34.
15. Fierro, L., DiPolo, R. & Llano, I. (1998) Intracellular calcium clearance in Purkinje cell somata from rat cerebellar slices. J. Physiol. (Lond.), 510, 499-512.
16. Gao, W., Dunbar, R.L., Chen, G., Reinert, K.C., Oberdick, J. & Ebner, T.J. (2003) Optical imaging of long-term depression in the mouse cerebellar cortex in vivo. J. Neurosci., 23, 1859-1866.
17. Garwicz, M. & Andersson, G. (1992) Spread of synaptic activity along parallel fibres in cat cerebellar anterior lobe. Exp. Brain Res., 88, 615-622.
18. Grinvald, A. (1985) Real-time optical imaging of neuronal activity: from single growth cones to the intact mammalian brain. Annu. Rev. Neurosci., 8, 263-305.
19. Gundappa-Sulur, G., De Schutter, E. & Bower, J.M. (1999) Ascending granule cell axon: an important component of cerebellar cortical circuitry. J. Comp. Neurol., 408, 580-596.
20. Harvey, R.J. & Napper, R.M. (1988) Quantitative study of granule and Purkinje cells in the cerebellar cortex of the rat. J. Comp. Neurol., 274, 151-157.
21. Harvey, R.J. & Napper, R.M. (1991) Quantitative studies on the mammalian cerebellum. Prog. Neurobiol., 36, 437-463.
22. Hassinen, I. & Chance, B. (1968) Oxidation-reduction properties of the mitochondrial flavoprotein chain. Biochem. Biophys. Res. Commun., 31, 895-900.
23. Isope, P. & Barbour, B. (2002) Properties of unitary granule cell - Purkinje cell synapses in adult rat cerebellar slices. J. Neurosci., 22, 9668-9678.
24. Ito, M. (1984) The Cerebellum and Neural Control. Raven Press, New York.
25. Ito, M. (2001) Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol. Rev., 81, 1143-1195.
26. Kolb, F.P., Arnold, G., Lerch, R., Straka, H. & Buttner-Ennever, J. (1997) Spatial distribution of field potential profiles in the cat cerebellar cortex evoked by peripheral and central inputs. Neuroscience, 81, 1155-1181.
27. Kunz, W.S. & Gellerich, F.N. (1993) Quantification of the content of fluorescent flavoproteins in mitochondria from liver, kidney cortex, skeletal muscle, and brain. Biochem. Med. Metab. Biol., 50, 103-110.
28. LaManna, J.C., Light, A.L., Pretsman, S.J. & Rosenthal, M. (1984) Oxygen insufficiency during hypoxic hypoxia in cat brain cortex. Brain Res., 293, 313-318.
29. Llinás, R. (1982) General discussion: radial connectivity in the cerebellar cortex: a novel view regarding the functional organization of the molecular layer. In Palay, S.L. & Chan-Palay, V. (Eds), The Cerebellum. Springer, New York, pp. 189-192.
30. Llinas, R. & Sugimori, M. (1992) The electrophysiology of the cerebellar Purkinje cell revisited. In Llinas, R. & Sotelo, C. (Eds), The Cerebellum Revisited. Springer, New York, pp. 167-181.
31. Martin, L.J., Blackstone, C.D., Huganir, R.L. & Price, D.L. (1992) Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron, 9, 259-270.
32. Masters, B.R. (1984) Noninvasive redox fluorometry: how light can be used to monitor alterations of corneal mitochondrial function. Curr. Eye Res., 3, 23-26.
33. Masters, B.R. & Chance, B. (1993) Redox confocal imaging: intrinsic fluorescent probes of cellular metabolism. In Mason, W.T. (Ed.), Fluorescent and Luminescent Probes for Biological Activity. Academic Press, New York.
34. Napper, R.M. & Harvey, R.J. (1988) Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. J. Comp. Neurol., 274, 168-177.
35. Nunzi, M.G., Birastiel, S., Bhattacharyya, B.J., Slater, N.T. & Mugnaini, E. (2001) Unipolar brush cells form a glutamatergic projection system within the mouse cerebellar cortex. J. Comp. Neurol., 434, 329-341.
36. Ragan, C.I. & Garland, P.B. (1969) The intra-mitochondrial localization of flavoproteins previously assigned to the respiratory chain. Eur. J. Biochem., 10, 399-410.
37. Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T. & Tanaka, R. (2003) Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence. J. Physiol (Lond.), 549, 919-927.
38. Shuttleworth, C.W., Brennan, A.M. & Connor, J.A. (2003) NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices. J. Neurosci., 23, 3196-3208.
39. Tempia, F., Alojado, M.E., Strata, P. & Knöpfel, T. (2001) Characterization of the mGluR(1)-mediated electrical and calcium signaling in Purkinje cells of mouse cerebellar slices. J. Neurophysiol., 86, 1389-1397.
40. Vranesic, I., Batchelor, A., Gahwiler, B.H., Garthwaite, J., Staub, C. & Knöpfel, T. (1991) Trans-ACPD-induced Ca2+ signals in cerebellar Purkinje cells. Neuroreport, 2, 759-762.