Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye

British Journal of Ophthalmology

Volumn 92, Issue 1, 2008, Pages 116-119

  Joffre, C ^a,c   Souchier, M ^b   Gregoire S ^a   Viau, S ^a   Bretillon, L ^a   Acar, N ^a   Bron, A M ^b   Creuzot Garcher, C ^b  

^a CEMAGREF   (France)

^b DIJON UNIVERSITY HOSPITAL   (France)

^c CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER; FATTY ACID; OIL; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID; TRIACYLGLYCEROL; WAX;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRY EYE; EVALUATION; EXCRETION; EYELID DISEASE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; INFORMATION PROCESSING; LIPID COMPOSITION; MALE; MASS FRAGMENTOGRAPHY; MEIBOMIAN GLAND; MEIBOMIAN GLAND DYSFUNCTION; METHYLATION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; AGED; CHEMISTRY; METABOLISM; METHODOLOGY; MIDDLE AGED; PROSPECTIVE STUDY;

AGED; CHROMATOGRAPHY, GAS; DRY EYE SYNDROMES; EYELID DISEASES; FATTY ACIDS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 38349137382     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2007.126144     Document Type: Article

References (35)

1. Foulks GN, Bron AJ. Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading. Ocul Surf 2003;1:107-26.
2. McCulley JP, Shine WE. The lipid layer: the outer surface of the ocular surface tear film. Biosci Rep 2001;21:407-18.
3. Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol 2001;45(Suppl 2):203-10S.
4. Greiner JV, Glonek T, Korb DR, et al. Phospholipids in meibomian gland secretion. Ophthalmic Res 1996;28:44-9.
5. McCulley JP, Shine WE. Meibomian secretions in chronic blepharitis. Adv Exp Med Biol. 1998;438:319-26.
6. Shine WE, McCulley JP. Role of wax ester fatty alcohols in chronic blepharitis. Invest Ophthalmol Vis Sci 1993;34:3515-21.
7. Mathers WD, Lane JA. Meibomian gland lipids, evaporation, and tear film stability. In: Sullivan DA et al. Lacrimal gland, tear film, and dry eye syndromes 2. New York: Plenum Press, 1998: 349-60.
8. Shine WE, McCulley JP. The role of cholesterol in chronic blepharitis. Invest Ophthalmol Vis Sci 1991;32:2272-80.
9. Nicolaides N, Kaitaranta JK, Rawdah TN, et al. Meibomian gland studies: comparison of steer and human lipids. Invest Ophthalmol Vis Sci 1981;20:522-36.
10. McCulley JP, Shine WE. Meibomian gland function and the tear lipid layer. Ocul Surf 2003;1:97-106.
11. Shine WE, McCulley JP. Keratoconjunctivitis sicca associated with meibomian secretion polar lipid abnormality. Arch Ophthalmol 1998;116:849-52.
12. Tiffany JM. Physiological functions of the meibomian glands. Prog Retin Eye Res 1995;14:47-74.
13. Tsai PS, Evans JE, Green KM, et al. Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol 2006;90:372-7.
14. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf 2004;2:124-30.
15. Driver PJ, Lemp MA. Meibomian gland dysfunction. Surv Ophthalmol 1996;40:343-67.
16. Hom MM, Martinson JR, Knapp LL, et al. Prevalence of Meibomian gland dysfunction. Optom Vis Sci 1990;67:710-2.
17. Ong BL. Relation between contact lens wear and Meibomian gland dysfunction. Optom Vis Sci 1996;73:208-10.
18. Craig JP, Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation. Optom Vis Sci 1997;74:8-13.
19. Mathers W. Evaporation from the ocular surface. Exp Eye Res 2004;78:389-94.
20. Goto E, Endo K, Suzuki A, et al. Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2003;44:533-9.
21. Morrison WL, Smith LM. Preparation of fatty acids methyl esters and dimethylacetals from lipids with boron fluoride methanol. J Lipid Res 1964;5:600-8.
22. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. Clao J 1995;21:221-32.
23. Lemp MA, Baudouin C, Baum J, et al. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007;5:75-92.
24. Sullivan BD, Evans JE, Dana MR, et al. Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions. Arch Ophthalmol 2006;124:1286-92.
25. Sullivan DA, Sullivan BD, Ullman MD, et al. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci 2000;41:3732-42.
26. Dougherty JM, Osgood JK, McCulley JP. The role of wax and sterol ester fatty acids in chronic blepharitis. Invest Ophthalmol Vis Sci 1991;32:1932-7.
27. McCulley JP, Shine W. A compositional based model for the tear film lipid layer. Trans Am Ophthalmol Soc 1997;95:79-88. [discussion 88-93]
28. Dougherty JM, McCulley JP. Bacterial lipases and chronic blepharitis. Invest Ophthalmol Vis Sci 1986;27:486-91.
29. Schonfeld P, Kahlert S, Reiser G. In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition. Biochem J 2004;383:121-8.
30. Kahlert S, Schonfeld P, Reiser G. The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes. Neurobiol Dis 2005;18:110-8.
31. Idel S, Ellinghaus P, Wolfrum C, et al. Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells. J Biol Chem 2002;277:49319-25.
32. McCulley JP, Dougherty JM, Deneau DG. Classification of chronic blepharitis. Ophthalmology 1982;89:1173-80.
33. Nagymihalyi A, Dikstein S, Tiffany JM. The influence of eyelid temperature on the delivery of meibomian oil. Exp Eye Res 2004;78:367-70.
34. Pflugfelder SC. Anti-inflammatory therapy of dry eye. Ocul Surf 2003;1:31-6.
35. Sullivan BD, Cermak JM, Sullivan RM, et al. Correlations between nutrient intake and the polar lipid profiles of meibomian gland secretions in women with Sjögren's syndrome. Adv Exp Med Biol 2002;506:441-7.