메뉴 건너뛰기




Volumn 24, Issue 1, 2008, Pages 27-33

EGFR Mutations and EGFR Tyrosine Kinase Inhibition in Non-Small Cell Lung Cancer

(1)  Miller, Vincent A a  

a NONE

Author keywords

EGFR mutation; Epidermal growth factor receptor (EGFR); erlotinib; gefitinib; kirsten ras (KRAS); oncogene addiction

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE;

EID: 38349120527     PISSN: 07492081     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soncn.2007.11.009     Document Type: Article
Times cited : (12)

References (54)
  • 1
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
    • Miller V.A., Kris M.G., Shah N., et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 22 (2004) 1103-1109
    • (2004) J Clin Oncol , vol.22 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 2
    • 10044242293 scopus 로고    scopus 로고
    • Gefitinib (ZD1839) therapy for advanced bronchioloalveolar lung cancer (BAC): Southwest Oncology Group (SWOG) Study S0126
    • (abstr)
    • West H., Franklin W.A., Gumerlock P.H., et al. Gefitinib (ZD1839) therapy for advanced bronchioloalveolar lung cancer (BAC): Southwest Oncology Group (SWOG) Study S0126. Proc Am Soc Clin Oncol 22 (2004) 7014 (abstr)
    • (2004) Proc Am Soc Clin Oncol , vol.22 , pp. 7014
    • West, H.1    Franklin, W.A.2    Gumerlock, P.H.3
  • 3
    • 0012381722 scopus 로고    scopus 로고
    • Multi-Institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M., Yano S., Giaccone G., et al. Multi-Institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21 (2003) 2237-2246
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 4
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 5
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., Janne P.A., Lee J.C., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304 (2004) 1497-1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 6
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W., Miller V., Zakowski M., et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101 (2004) 13306-13311
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 7
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • Manning G., Whyte D.B., Martinez R., et al. The protein kinase complement of the human genome. Science 298 (2002) 1912-1934
    • (2002) Science , vol.298 , pp. 1912-1934
    • Manning, G.1    Whyte, D.B.2    Martinez, R.3
  • 8
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: the biology of ErbB-2 and ErbB-3
    • Citri A., Skaria K.B., and Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 284 (2003) 54-65
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 9
    • 0037145061 scopus 로고    scopus 로고
    • Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
    • Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110 (2002) 669-672
    • (2002) Cell , vol.110 , pp. 669-672
    • Schlessinger, J.1
  • 10
    • 0037429737 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: mechanisms of activation and signalling
    • Jorissen R.N., Walker F., Pouliot N., et al. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 284 (2003) 31-53
    • (2003) Exp Cell Res , vol.284 , pp. 31-53
    • Jorissen, R.N.1    Walker, F.2    Pouliot, N.3
  • 11
  • 12
    • 1042284385 scopus 로고    scopus 로고
    • The epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) shows promising activity in patients with bronchioloalveolar cell carcinoma (BAC): preliminary results of a phase II trial
    • (abstr)
    • Miller V., Patel J., Shah N., et al. The epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) shows promising activity in patients with bronchioloalveolar cell carcinoma (BAC): preliminary results of a phase II trial. Proc Am Soc Clin Oncol 22 (2003) 2491 (abstr)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 2491
    • Miller, V.1    Patel, J.2    Shah, N.3
  • 13
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial
    • (abstr)
    • Shepherd F.A., Pereira J., Ciuleanu T.E., et al. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Proc Am Soc Clin Onc 22 (2004) 7022 (abstr)
    • (2004) Proc Am Soc Clin Onc , vol.22 , pp. 7022
    • Shepherd, F.A.1    Pereira, J.2    Ciuleanu, T.E.3
  • 14
    • 3843116718 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer
    • Parra H.S., Cavina R., Latteri F., et al. Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer. Br J Cancer 91 (2004) 208-212
    • (2004) Br J Cancer , vol.91 , pp. 208-212
    • Parra, H.S.1    Cavina, R.2    Latteri, F.3
  • 15
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak F.M., Zakowski M.F., Miller V.A., et al. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 6 (2000) 4885-4892
    • (2000) Clin Cancer Res , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3
  • 16
    • 19044370434 scopus 로고    scopus 로고
    • Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
    • Moody S.E., Sarkisian C.J., Hahn K.T., et al. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell 2 (2002) 451-461
    • (2002) Cancer Cell , vol.2 , pp. 451-461
    • Moody, S.E.1    Sarkisian, C.J.2    Hahn, K.T.3
  • 17
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • Huettner C.S., Zhang P., Van Etten R.A., et al. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 24 (2000) 57-60
    • (2000) Nat Genet , vol.24 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3
  • 18
    • 0035893318 scopus 로고    scopus 로고
    • Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
    • Fisher G.H., Wellen S.L., Klimstra D., et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15 (2001) 3249-3262
    • (2001) Genes Dev , vol.15 , pp. 3249-3262
    • Fisher, G.H.1    Wellen, S.L.2    Klimstra, D.3
  • 19
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher D.W., and Bishop J.M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4 (1999) 199-207
    • (1999) Mol Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 20
    • 0033614962 scopus 로고    scopus 로고
    • Essential role for oncogenic Ras in tumour maintenance
    • Chin L., Tam A., Pomerantz J., et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400 (1999) 468-472
    • (1999) Nature , vol.400 , pp. 468-472
    • Chin, L.1    Tam, A.2    Pomerantz, J.3
  • 21
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein I. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297 (2002) 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.1
  • 22
    • 0036216405 scopus 로고    scopus 로고
    • STI571 (Gleevec) as a paradigm for cancer therapy
    • Druker B. STI571 (Gleevec) as a paradigm for cancer therapy. Trends Mol Med 8 suppl 4 (2002) S14-S18
    • (2002) Trends Mol Med , vol.8 , Issue.SUPPL. 4
    • Druker, B.1
  • 23
    • 0035211136 scopus 로고    scopus 로고
    • Targeting c-kit mutations in solid tumors; scientific rationale and novel therapeutic options
    • Demetri G.D. Targeting c-kit mutations in solid tumors; scientific rationale and novel therapeutic options. Semin Oncol 28 (2001) 19-26
    • (2001) Semin Oncol , vol.28 , pp. 19-26
    • Demetri, G.D.1
  • 24
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J., DeAngelo D.J., Gotlib J., et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348 (2003) 1201-1214
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    DeAngelo, D.J.2    Gotlib, J.3
  • 25
    • 2442648882 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine kinome in colorectal cancers
    • Bardelli A., Parsons D.W., Silliman N., et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 304 (2004) 1164-1166
    • (2004) Science , vol.304 , pp. 1164-1166
    • Bardelli, A.1    Parsons, D.W.2    Silliman, N.3
  • 26
    • 17844390172 scopus 로고    scopus 로고
    • EGFR mutations, small molecule kinase inhibitors, and non-small cell lung cancer: current knowledge and future directions
    • Pao W., and Miller V.A. EGFR mutations, small molecule kinase inhibitors, and non-small cell lung cancer: current knowledge and future directions. J Clin Oncol 23 (2005) 2556-2568
    • (2005) J Clin Oncol , vol.23 , pp. 2556-2568
    • Pao, W.1    Miller, V.A.2
  • 27
    • 11144333540 scopus 로고    scopus 로고
    • Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer
    • Lee J.W., Soung Y.H., Kim S.Y., et al. Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer. Int J Cancer 113 (2004) 510-511
    • (2004) Int J Cancer , vol.113 , pp. 510-511
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 28
    • 0023663092 scopus 로고
    • Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
    • Honegger A.M., Dull T.J., Felder S., et al. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell 51 (1987) 199-209
    • (1987) Cell , vol.51 , pp. 199-209
    • Honegger, A.M.1    Dull, T.J.2    Felder, S.3
  • 29
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse M., and Kuriyan J. The conformational plasticity of protein kinases. Cell 109 (2002) 275-282
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 30
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
    • Greulich H., Chen T.H., Feng W., et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2 (2005) e313
    • (2005) PLoS Med , vol.2
    • Greulich, H.1    Chen, T.H.2    Feng, W.3
  • 31
    • 33846187218 scopus 로고    scopus 로고
    • Update on epidermal growth factor receptor mutations in non-small cell lung cancer
    • Riely G.J., Politi K.A., Miller V.A., et al. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 12 (2006) 7232-7241
    • (2006) Clin Cancer Res , vol.12 , pp. 7232-7241
    • Riely, G.J.1    Politi, K.A.2    Miller, V.A.3
  • 32
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N., Chang A., Parikh P., et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366 (2005) 1527-1537
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 33
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
    • Shigematsu H., Takahashi T., Nomura M., et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 65 (2005) 1642-1646
    • (2005) Cancer Res , vol.65 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3
  • 34
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard D.A., Johnson B.E., Amler L.C., et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23 (2005) 5900-5909
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 35
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W., Wang T.Y., Riely G.J., et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2 (2005) e17
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 36
    • 33947389287 scopus 로고    scopus 로고
    • EGFR mutation and copy number, EGFR protein expression and KRAS mutation as predictors of outcome with erlotinib in bronchioloalveolar cell carcinoma (BAC): results of a prospective phase II trial
    • (abstr 7003)
    • Miller V.A., Zakowski M., Riely G.J., et al. EGFR mutation and copy number, EGFR protein expression and KRAS mutation as predictors of outcome with erlotinib in bronchioloalveolar cell carcinoma (BAC): results of a prospective phase II trial. J Clin Oncol 24 (2006) 18S (abstr 7003)
    • (2006) J Clin Oncol , vol.24
    • Miller, V.A.1    Zakowski, M.2    Riely, G.J.3
  • 37
    • 5644293135 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
    • Tracy S., Mukohara T., Hansen M., et al. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res 64 (2004) 7241-7244
    • (2004) Cancer Res , vol.64 , pp. 7241-7244
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3
  • 38
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F., Hirsch F.R., Rossi E., et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97 (2005) 643-655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 39
    • 24144448896 scopus 로고    scopus 로고
    • Molecular analysis of the epidermal growth factor receptor (EGFR) gene and protein expression in patients treated with erlotinib in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial BR.21
    • (abstr 7007)
    • Tsao M.S., Sakurada A., Lorimer J., et al. Molecular analysis of the epidermal growth factor receptor (EGFR) gene and protein expression in patients treated with erlotinib in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial BR.21. J Clin Oncol 23 16S (2005) (abstr 7007)
    • (2005) J Clin Oncol , vol.23 , Issue.16 S
    • Tsao, M.S.1    Sakurada, A.2    Lorimer, J.3
  • 40
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A., Suzuki T., Fukuhara T., et al. Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 24 (2006) 3340-3346
    • (2006) J Clin Oncol , vol.24 , pp. 3340-3346
    • Inoue, A.1    Suzuki, T.2    Fukuhara, T.3
  • 41
    • 33846702438 scopus 로고    scopus 로고
    • Prospective analysis of the epidermal growth factor receptor gene mutations in non-small cell lung cancer in Japan
    • (abstr 7077)
    • Morikawa A., Inoue A., Suzuki T., et al. Prospective analysis of the epidermal growth factor receptor gene mutations in non-small cell lung cancer in Japan. J Clin Oncol 24 18S (2006) (abstr 7077)
    • (2006) J Clin Oncol , vol.24 , Issue.18 S
    • Morikawa, A.1    Inoue, A.2    Suzuki, T.3
  • 42
    • 33845434121 scopus 로고    scopus 로고
    • A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR)
    • (abstr 7020)
    • Paz-Ares L., Sanchez J.M., Garcia-Velasco A., et al. A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR). J Clin Oncol (2006) 18S (abstr 7020)
    • (2006) J Clin Oncol
    • Paz-Ares, L.1    Sanchez, J.M.2    Garcia-Velasco, A.3
  • 43
    • 34250009465 scopus 로고    scopus 로고
    • Phase II study of the efficacy of gefitinib in patients with non-small cell lung cancer with the EGFR mutations
    • (abstr 7183)
    • Sunaga N., Yanagitani N., Kaira K., et al. Phase II study of the efficacy of gefitinib in patients with non-small cell lung cancer with the EGFR mutations. J Clin Oncol 24 (2006) 18S (abstr 7183)
    • (2006) J Clin Oncol , vol.24
    • Sunaga, N.1    Yanagitani, N.2    Kaira, K.3
  • 44
    • 34249986515 scopus 로고    scopus 로고
    • Phase II study of gefitinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutations detected by PNA-LNA PCR clamp
    • (abstr 7076)
    • Sutani A., Nagai Y., Udagawa K., et al. Phase II study of gefitinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutations detected by PNA-LNA PCR clamp. J Clin Oncol 24 (2006) 18S (abstr 7076)
    • (2006) J Clin Oncol , vol.24
    • Sutani, A.1    Nagai, Y.2    Udagawa, K.3
  • 45
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • Asahina H., Yamazaki K., Kinoshita I., et al. A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer 95 (2006) 998-1004
    • (2006) Br J Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3
  • 46
    • 36949006637 scopus 로고    scopus 로고
    • iTARGET: A phase II trial to assess the response to gefitinib in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) tumors
    • (abstr 7504)
    • Sequist L.V., Martins R.G., Spigel D., et al. iTARGET: A phase II trial to assess the response to gefitinib in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) tumors. J Clin Oncol 25 (2007) 18S (abstr 7504)
    • (2007) J Clin Oncol , vol.25
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 47
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H., Lin L., Takahashi T., et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97 (2005) 339-346
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 48
    • 0033785313 scopus 로고    scopus 로고
    • Apoptosis and cancer: strategies for integrating programmed cell death
    • Reed J. Apoptosis and cancer: strategies for integrating programmed cell death. Semin Hematol 37 (2000) 9-16
    • (2000) Semin Hematol , vol.37 , pp. 9-16
    • Reed, J.1
  • 49
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
    • Engelman J.A., Mukohara T., Zejnullahu K., et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 116 (2006) 2695-2706
    • (2006) J Clin Invest , vol.116 , pp. 2695-2706
    • Engelman, J.A.1    Mukohara, T.2    Zejnullahu, K.3
  • 50
    • 23844544647 scopus 로고    scopus 로고
    • Rapid PCR-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
    • Pan Q., Pao W., and Ladanyi M. Rapid PCR-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 7 (2005) 396-403
    • (2005) J Mol Diagn , vol.7 , pp. 396-403
    • Pan, Q.1    Pao, W.2    Ladanyi, M.3
  • 51
    • 32944468710 scopus 로고    scopus 로고
    • A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening
    • Janne P.A., Borras A.M., Kuang Y., et al. A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening. Clin Cancer Res 12 (2006) 751-758
    • (2006) Clin Cancer Res , vol.12 , pp. 751-758
    • Janne, P.A.1    Borras, A.M.2    Kuang, Y.3
  • 52
    • 20044364933 scopus 로고    scopus 로고
    • EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    • Marchetti A., Martella C., Felicioni L., et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 23 (2005) 857-865
    • (2005) J Clin Oncol , vol.23 , pp. 857-865
    • Marchetti, A.1    Martella, C.2    Felicioni, L.3
  • 53
    • 33644539850 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
    • Endo K., Konishi A., Sasaki H., et al. Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer 50 (2005) 375-384
    • (2005) Lung Cancer , vol.50 , pp. 375-384
    • Endo, K.1    Konishi, A.2    Sasaki, H.3
  • 54
    • 23844544647 scopus 로고    scopus 로고
    • Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
    • Pan Q., Pao W., and Ladanyi M. Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 7 (2005) 396-403
    • (2005) J Mol Diagn , vol.7 , pp. 396-403
    • Pan, Q.1    Pao, W.2    Ladanyi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.