In vitro biotransformation of amitriptyline and imipramine with rat hepatic S9 fraction: Evaluation of the toxicity with spirotox and thamnotoxkit F™ tests

Archives of Environmental Contamination and Toxicology

Volumn 54, Issue 2, 2008, Pages 266-273

  Nałȩcz Jawecki, Grzegorz ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Antidepressants; Metabolites ; Pharmaceuticals; Spirostomum ambiguum; Thamnocephalus platyurus

Indexed keywords

AMITRIPTYLINE; CLOMIPRAMINE; DESIPRAMINE; IMIPRAMINE; IODIDE; NORTRIPTYLINE;

BIOTRANSFORMATION; DRUG; ECOTOXICOLOGY; METABOLITE; POLLUTION EFFECT; POLLUTION EXPOSURE; RODENT; TOXICITY;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CRUSTACEA; DRUG METABOLISM; ECOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; RAT;

AMITRIPTYLINE; ANIMALS; ANOSTRACA; BIOTRANSFORMATION; CILIOPHORA; DESIPRAMINE; IMIPRAMINE; LETHAL DOSE 50; LIVER; MALE; NORTRIPTYLINE; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

CRUSTACEA; PROTOZOA; RATTUS; SPIROSTOMUM AMBIGUUM; THAMNOCEPHALUS PLATYURUS;

EID: 38349084046     PISSN: 00904341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00244-007-9052-y     Document Type: Article

References (28)

1. Brever-Pfaff U (2004) The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metab Rev 36:723-746
2. Bull S, Catalani P, Garle M, Coecke S, Clothier R (1999) Imipramine for cytochrome P450 activity determination: a multiple-species metabolic probe. Toxicol in Vitro 13:537-541
3. Calleja MC, Persoone G, Geladi P (1994) Human acute toxicity prediction of the first 50 MEIC chemicals by a battery of ecotoxicological tests and physicochemical properties. Fd Chem Toxicol 32:173-187
4. Coutts RT, Bach MV, Baker GB (1997) Metabolism of amitriptyline with CYP2D6 expressed in a human cell line. Xenobiotica 27:33-47
5. Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122-159
6. Gerner P (2004) Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again. Reg Anesth Pain Med 29:286-289
7. Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5-17
8. Hilton MJ, Thomas KV (2003) Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 1015:129-141
9. Hiratsuka M, Mizugaki M (2001) Genetic polymorphisms in drug-metabolizing enzymes and drug targets. Mol Genet Metabol 73:298-305
10. Kahru A, Borchardt B (1994) Toxicity of 39 MEIC chemicals to bioluminescent Photobacteria (The Biotox™ test): Correlation with other test systems. ATLA 22:147-160
11. Lin G, McKay G, Midha KK (1996) Characterization of metabolites of clozapine N-oxide in the rat by micro-column high performance liquid chromatography/mass spectrometry with electrospray interface. J Pharm Biomed Anal 14:1561-1577
12. McEvoy GK (2000) AHFS Drug Information®. ASHP, Bethesda, Maryland, pp 2013-2036
13. Nałȩcz-Jawecki G (2005) Spirotox test-Spirostomum ambiguum acute toxicity test. In: Blaise C, Férard J (eds) Small-scale freshwater toxicity investigations. Volume 1-toxicity test methods. Springer, Dordrecht, pp 299-322
14. Nałȩcz-Jawecki G, Michniewicz M, Stufka-Olczyk J, Sawicki J (2000) Toxicity of major pollutants occurring in the pulp and paper mill effluents. A Poloniae Toxicol 8:263-269
15. Nałȩcz-Jawecki G, Persoone G (2006) Toxicity of selected pharmaceuticals to the anostracan crustacean Thamnocephalus platyurus comparison of sublethal and lethal effect levels with the 1h Rapidtoxkit and the 24h Thamnotoxkit microbiotests. Environ Sci Pollut Res 13:22-27
16. Nałȩcz-Jawecki G, Sawicki J (2003) The toxicity of selected pharmaceuticals to the protozoa Spirostomum ambiguum and Tetrahymena termophila. Fresenius Environ Bull 12:840-843
17. Nałȩcz-Jawecki G, Sawicki J (2005) Influence of water hardness on the toxicity of selected pharmaceuticals and metals to the protozoa Spirostomum ambiguum and Tetrahymena termophila. Fresenius Environ Bull 14:873-877
18. Nielsen KK, Brosen K (1993) High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine. J Chromatogr 612:87-94
19. Otani K, Mihara K, Yasui-Furukori N, Suzuki A, Kondo T, Kaneko S (2002) Clinical implications of pharmacogenetics of antidepressants. International Congress Series, Elsevier, pp 105-109
20. Shen WW (1997) The metabolism of psychoactive drugs: A review of enzymatic biotransformation and inhibition. Biol Psychiatry 41:814-826
21. Strumper D, Durieux ME (2004) Antidepressants as long-acting local anesthetics. Reg Anesth Pain Med 29:277-285
22. Ternes TA (2001) Analytical methods for the determination of pharmaceuticals in aqueous environmental samples. Trends Anal Chem 20:419-434
23. Thamnotoxkit F (1995) Crustacean toxicity screening test for freshwater. Standard operational procedure. MicroBioTests Inc., Nazareth, Belgium, pp 23
24. Thummel KE, Kunze KL, Shen DD (1997) Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Advanced Drug Delivery Rev 27:99-127
25. Vetulani J, Nalepa I (2000) Antidepressants: Past, present and future. Eur J Pharmacol 405:351-363
26. Webb SF (2001a) A data based perspective on the environmental risk assessment of human pharmaceuticals I-collation of available ecotoxicity data. In: Kümmerer K (ed) Pharmaceuticals in the environment. Sources, fate, effects and risks. Springer-Verlag, Berlin, pp 176-201
27. Webb SF (2001b) A data based perspective on the environmental risk assessment of human pharmaceuticals II-aquatic risk characterization. In: Kümmerer K (ed) Pharmaceuticals in the environment. Sources, fate, effects and risks. Springer-Verlag, Berlin, pp 203-219
28. Zuccato E, Bagnati R, Fioretti F, Natangelo M, Calamari D, Fanelli R (2001) Environmental loads and detection of pharmaceuticals in Italy. In: Kümmerer K (ed) Pharmaceuticals in the environment. Sources, fate, effects and risks. Springer-Verlag, Berlin, pp 19-27