Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study

Acta Paediatrica, International Journal of Paediatrics

Volumn 97, Issue 1, 2008, Pages 31-34

  Sakellaris, George ^a,d   Nasis, George ^b   Kotsiou, Maria ^c   Tamiolaki, Maria ^c   Charissis, Giorgos ^a   Evangeliou, Athanasios ^a  

^a University Hospital of Heraklio   (Greece)

^b Army Share Fund Hospital   (Greece)

^c Aristotle University of Thessaloniki   (Greece)

^d NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; PLACEBO;

ADOLESCENT; AMNESIA; ARTICLE; CHILD; CLINICAL TRIAL; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG EFFECT; FATIGUE; HEADACHE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; NEUROPROTECTION; PILOT STUDY; PREVENTION AND CONTROL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TRAUMATIC BRAIN INJURY; TREATMENT DURATION;

ADOLESCENT; BRAIN INJURIES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CREATINE; DIZZINESS; FATIGUE; HUMANS; INFANT; LENGTH OF STAY; NEUROPROTECTIVE AGENTS; PILOT PROJECTS; POST-TRAUMATIC HEADACHE; PROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 38349082603     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2007.00529.x     Document Type: Article

References (24)

1. Tegas III. JJ, DiScala C., Ramenofsky MC, Barlow B. Mortality and head injury: the paediatric perspective. J Pediatr Surg 1990 25 : 92 6.
2. Sullivan G, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Ann Neurol 2000 48 : 723 9.
3. Scheff SW, Dhillon HS. Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury. Neurochem Res 2004 29 : 469 79.
4. Gasparovic C, Arfai N, Smid N, Feeney DM. Decrease and recovery of N-acetylaspartase/creatine in rat brain remote from focal injury. J Neurotrauma 2001 18 : 241 6.
5. Stockler S, Marescau B, De Deyn PP, Trijbels JM, Hanefeld F. Guanidino compounds in guanidinoacetate methyltransferase deficiency, a new inborn error of creatine synthesis. Metabolism 1997 46 : 1189 93.
6. Schulze A, Bachert P, Schlemmer H, Harting I, Polster T, Salomons GS, et al. Lack of creatine in muscle and brain in an adult with GAMT deficiency. Ann Neurol 2003 53 : 248 51.
7. Tarnopolsky MA, Roy BD, MacDonald JR. A randomized controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 1997 20 : 1502 9.
8. Berger R, Middelanis J, Vaihinger HM, Mies G, Wilken B, Jensen A. Creatine protects the immature brain from hypoxic damage: dose-effect relationship. Brain Res 1999 816 : 124 30.
9. Balestrino M, Rebaudo R, Lunardi G. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship. Brain Res 1999 816 : 124 30.
10. Felber S, Skladal D, Wyss M, Kremser C, Koller A, Sperl W. Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study. Neurol Res 2000 22 : 145 50.
11. Gordon A, Hultmann E, Kaijser L, Kristjansson S, Rolf CJ, Nyquist O, Sylven C. Creatine supplementation in chronic heart failure increases skeletal muscles creatine phosphate and muscle performance. Cardiovascular Res 1995 30 : 413 8.
12. Holtzman D, Togliatti A, Khait I, Jensen F. Creatine increases survival and suppresses seizures in the hypoxic immature rat. Paediatric Res 1998 44 : 410 4.
13. Sakellaris G, Kotsiou M, Tamiolaki M, Kalostos G, Tsapaki E, Spanaki M, et al. Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration. An open label randomised pilot study. J. Trauma 2006 61 : 322 9.
14. Martelli MF, Grayson RL, Zasler ND. Posttraumatic headache: neuropsychological and psychological effects and treatment implications. J Head Trauma Rehabil 1999 14 : 49 69.
15. Evans RW. Post-traumatic headaches. Neurol Clin 2004 22 : 237 49, viii.
16. Lane JC, Arciniegas DB. Post-traumatic headache. Curr Treat Options Neurol 2002 4 : 89 104.
17. Wilson MC, Krolczyk SJ. Pediatric post-traumatic headache. Curr Pain Headache Rep 2006 10 : 387 90.
18. Ylikoski J, Palva T, Sanna M. Dizziness after head trauma: clinical and morphologic findings. Am J Otol 1982 3 : 343 52.
19. Eviatar L, Bergtraum M, Randel RM. Post-traumatic vertigo in children: a diagnostic approach. Paediatric Neurol 1986 2 : 61 6.
20. Stulemeijer M, van der Werf S, Bleijenberg G, Biert J, Brauer J, E Vos P. Recovery from mild traumatic brain injury: a focus on fatigue. J Neurol 2006 253 : 1041 7. Epub 2006 May 17.
21. Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med 1999 5 : 347 50.
22. Lifshitz J, Friberg H, Neumar RW, Raghupathi R, Welsh FA, Janmey P, et al. Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus. J Cereb Blood Flow Metab 2003 23 : 219 31.
23. Borges N, Cerejo A, Santos A, Sarmento A, Azevedo I. Changes in rat cerebral mitochondrial succinate dehydrogenase activity after brain trauma. Int J Neurosci 2004 114 : 217 27.
24. Eppenberger-Eberhardt M, Riesinger I, Messerli M, Schwarb P, Muller M, Eppenberger HM, et al. Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase. J Cell Biol 1991 113 : 289 302.