Impact of age, body mass index, insulin resistance and proteinuria on the kidney function in obese patients with Type 2 diabetes and renal insufficiency

Clinical Nephrology

Volumn 69, Issue 1, 2008, Pages 10-17

  Koch, M ^a,d   Belen, A ^a   Fussholler A ^b   Zitta, S ^c   Haastert, B ^b   Trapp, R ^a  

^a Center of Nephrology   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d Leibniz Center at Heinrich Heine University ^*  (Germany)

Author keywords

Creatinine clearance; Diabetes; Glomerular filtration rate; Inulin clearance; Obesity; Prediction quation; Prognostic factors; Renal insufficiency

Indexed keywords

ALBUMIN; BRAIN NATRIURETIC PEPTIDE; CREATININE; CYSTATIN C; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INULIN; NITROGEN; UREA;

ADULT; AGE DISTRIBUTION; AGED; ALBUMIN BLOOD LEVEL; ALBUMINURIA; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTERMETHOD COMPARISON; INULIN CLEARANCE; KIDNEY FAILURE; KIDNEY FUNCTION; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREDICTION; PROGNOSIS; PROTEINURIA; SAMPLE SIZE; STATISTICAL SIGNIFICANCE; UREA NITROGEN BLOOD LEVEL; VALIDATION PROCESS; WATER CONTENT;

EID: 38349057765     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CNP69010     Document Type: Article

References (25)

1. Alvestrand A. 1997 Carbohydrate and insulin metabolism in renal failure. Kidney Int. 1997; Suppl 62: S48-S52.
2. Anastasio P, Spitali L, Frangiosa A, Molino D, Stellato D, Cirillo E, Pollastro RM, Capodicasa L, Sepe J, Federico P, Gaspare DS. Glomerular filtration rate in severely overweight normotensive humans. Am J Kidney Dis. 2000; 35: 1144-1148.
3. Axelsson J, Rashid QA, Suliman ME, Honda H, Pecoits-Filho R, Heimburger O, Lindholm B, Cederholm T, Stenvinkel P. Truncal fat mass as a contributor to inflammation in end-stage renal disease. Am J Clin Nutr. 2004; 80: 1222-1229.
4. Bostom AG, Kronenberg F, Ritz E. Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels. J Am Soc Nephrol. 2002; 13: 2140-2144.
5. Branten AJ, Vervoort G, Wetzels JF. Serum creatinine is a poor marker of GFR in nephrotic syndrome. Nephrol Dial Transplant. 2005; 20:707-711.
6. Burkhardt H, Bojarsky G, Gretz N, Gladisch R, Burkhardt H, Bojarsky G, Gretz N, Gladisch R. Creatinine clearance, Cockcroft-Gault formula and cystatin C: estimators of true glomerular filtration rate in the elderly? Gerontology. 2002; 48:140-146.
7. Cirillo M, Anastasio P, De Santo NG. Relationship of gender, age, and body mass index to errors in predicted kidney function. Nephrol Dial Transplant. 2005; 20: 1791-1798.
8. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16: 31-41.
9. Estelberger W, Petek W, Zitta S, Mauric A, Horn S, Holzer H, Pogglitsch H. Determination of the glomerular filtration rate by identification of sinistrin kinetics. Eur J Clin Chem Clin Biochem. 1995; 33: 201-209.
10. Fontsere N, Salinas I, Bonal J, Bayes B, Riba J, Torres F, Rios J, Sanmarti A, Romero R. Are prediction equations for glomerular filtration rate useful for the long-term monitoring of Type 2 diabetic patients? Nephrol Dial Transplant. 2006; 21: 2152-2158.
11. Kalambokis GN, Tsatsoulis AA, Tsianos EV. The edematogenie properties of insulin. Am J Kidney Dis. 2004; 44: 575-590.
12. Kobayashi S, Maesato K, Moriya H, Ohtake T, Ikeda T. Insulin resistance in patients with chronic kidney disease. Am J Kidney Dis. 2005; 45: 275-280.
13. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130: 461-470.
14. Lottha K, Kronenberg F, Mayer G. Errechnete Nierenfunktion: Nutzen und Problematik der MDRD-Formel. Dtsch Med Wochenschr. 2005; 130: 2021-2024.
15. Macdonald J, Marcora S, Jibani M, Roberts G, Kumwenda M, Glover R, Barron J, Lemmey A. GFR estimation using cystatin C is not independent of body composition. Am J Kidney Dis. 2006; 48: 712-719.
16. Matsumoto H, Nakao T, Okada T, Nagaoka Y, Iwasawa H, Tomaru R, Wada T. Insulin resistance contributes to obesity-related proteinuria. Intern Med. 2005; 44: 548-553.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28: 412-419.
18. McCord J, Mundy BJ, Hudson MP, Maisel AS, Hollander JE, Abraham WT, Steg PG, Omland T, Knudsen CW, Sandberg KR, McCullough PA. Relationship between obesity and B-type natriuretic peptide levels. Arch Intern Med. 2004; 164: 2247-2252.
19. Rigalleau V, Lasseur C, Perlemoine C, Barthe N, Raffaitin C, de la Faille R, Combe C, Gin H. A simplified Cockcroft-Gault formula to improve the prediction of the glomerular filtration rate in diabetic patients. Diabetes Metab. 2005; 32: 56-62.
20. Saracino A, Morrone LF, Suriano V, Niccoli-Asabella A, Ramunni A, Fanelli M, Rubini G, Coratelli P. A simple method for correcting overestimated glomerular filtration rate in obese subjects evaluated by the Cockcroft and Gault formula: a comparison with 51Cr EDTA clearance. Clin Nephrol. 2004; 62: 97-103.
21. Soper CP, Barron JL, Hyer SL. Long-term glycaemic control directly correlates with glomerular filtration rate in early Type 1 diabetes mellitus before the onset of microalbuminuria. Diabet Med. 1998; 15: 1010-1014.
22. Valensi P, Assayag M, Busby M, Paries J, Lormeau B, Attali JR. Microalbuminuria in obese patients with or without hypertension. Int J Obes Relat Metab Disord. 1996; 20: 574-579.
23. Verhave JC, Fesler P, Ribstein J, du CG, Mimran A. Estimation of renal function in subjects with normal serum creatinine levels: influence of age and body mass index. Am J Kidney Dis. 2005; 46: 233-241.
24. Vervoort G, Willems HL, Wetzels JF, Vervoort G, Willems HL, Wetzels JFM. Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: validity of a new (MDRD) prediction equation. Nephrol Dial Transplant. 2002; 17: 1909-1913.
25. Zitta S, Stoschitzky K, Zweiker R, Oettl K, Reibnegger G, Holzer H, Estelberger W. Dynamic renal function testing by compartmental analysis: assessment of renal functional reserve in essential hypertension. Nephrol Dial Transplant. 2000; 15: 1162-1169.