Insulin resistance contributes to obesity-related proteinuria

Internal Medicine

Volumn 44, Issue 6, 2005, Pages 548-553

  Matsumoto, Hiroshi ^a   Nakao, Toshiyuki ^a   Okada, Tomonari ^a   Nagaoka, Yume ^a   Iwasawa, Hideaki ^a   Tomaru, Ryo ^a   Wada, Toshikazu ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Insulin resistance; Minor glomerular abnormality; Overweight; Proteinuria; Troglitazone

Indexed keywords

CREATININE; GLUCOSE; INSULIN; INSULIN SENSITIZING AGENT; TROGLITAZONE;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DIET RESTRICTION; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KIDNEY BIOPSY; MALE; NEPHROSCLEROSIS; OBESITY; PATHOGENESIS; PROTEINURIA;

ADULT; BIOPSY; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CHROMANS; CREATININE; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; KIDNEY; MALE; MODELS, BIOLOGICAL; OBESITY; PROTEINURIA; RISK FACTORS; THIAZOLIDINEDIONES;

EID: 21644472959     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.44.548     Document Type: Article

References (19)

1. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. The nephrotic syndrome: A complication of massive obesity. Ann Intern Med 81: 440-447, 1974.
2. Kasiske BL, Napier J. Glomerular sclerosis in patients with massive obesity. Am J Nephrol 5: 45-50, 1985.
3. Praga M, Hernandez E, Morales E, et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 16: 1790-1798, 2001.
4. Kambham N, Markowitz GS, Valeri AM, Lin J, D'Agati VD. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 59: 1498-1509, 2001.
5. Chagnac A, Weinstein T, Korzets A, Ramadan E, Hirsch J, Gafter U. Glomerular hemodinamics in severe obesity. Am J Physiol Renal Physiol 278: F817-F822, 2000.
6. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194, 1991.
7. Juncos LA, Ito S. Disparate effects of insulin on isolated rabbit afferent and efferent arterioles. J Clin Invest 92: 1981-1985, 1993.
8. Kuzuya T, Nakagawa S, Satoh J, et al. Reports of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus. Diabetes Res Clin Pract 55: 65-85, 2002.
9. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
10. Laakso M. How good a marker is insulin level for insulin resistance? Am J Epidemiol 137: 959-965, 1993.
11. Hall JE, Brandsy MW, Henegar JR, Shek EW. Abdominal kidney function as a cause and consequence of obesity hypertension. Clin Exp Pharmacol Physiol 25: 58-64, 1998.
12. Ribstein J, du Cailar G, Mimran A. Combined renal effects of overweight and hypertension 28: 610-615, 1995.
13. Foster GD, Wadden TA, Makris AP, et al. Primary care physicians' attitudes about obesity and treatment. Obes Res 11: 1168-1177, 2003.
14. Wesson DE, Kurtzman NA, Frommer JP. Massive obesity and nephrotic proteinuria with a normal renal biopsy. Nephron 40: 235-237, 1985.
15. McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism 53: 495-499, 2004.
16. Bianchi S, Bigazzi R, Valtriani C, et al. Elevated serum insulin levels in patients with essential hypertension and microalbuminuria. Hypertension 23: 681-687, 1994.
17. Ogihara T, Rakugi H, Ikegami H, Mikami H, Masuo K. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens 8: 316-320, 1995.
18. Rocchini AP, Key J, Bondie D, et al. The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med 31: 580-585, 1989.
19. Guan Y, Breyer MD. Peroxisome proliferator-activated receptor (PPARs): novel therapeutic targets in renal disease. Kidney Int 60: 14-30, 2001.