Increased micronucleus frequency in phytohaemagglutinin-stimulated blood cells of patients with vitiligo

Journal of the European Academy of Dermatology and Venereology

Volumn 22, Issue 2, 2008, Pages 162-167

  Donmez altuntas, H ^a,b   Sut, Z ^a   Ferahbas, A ^a   Hamurcu, Z ^b   Demirtas, H ^a  

^a Erciyes University   (India)

^b ERCIYES UNIVERSITY   (Turkey)

Author keywords

Autoimmune diseases; Keywords; Lymphocytes; Micronucleus; Skin diseases; Vitiligo

Indexed keywords

PHYTOHEMAGGLUTININ; REACTIVE NITROGEN SPECIES;

ADULT; AGE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD CULTURE; BLOOD SAMPLING; CELL STIMULATION; CHROMOSOME DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; FEMALE; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS; MONONUCLEAR CELL; OXIDATIVE STRESS; PHOTOTHERAPY; PIGMENT DISORDER; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; VITILIGO;

ADOLESCENT; ADULT; BLOOD CELLS; CASE-CONTROL STUDIES; CELLS, CULTURED; CHILD; DNA DAMAGE; FEMALE; HUMANS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MITOGENS; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES; VITILIGO;

EID: 38349042317     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2007.02356.x     Document Type: Article

References (30)

1. Passeron T, Ortonne J-P. Physiopathology and genetics of vitiligo. J Autoimmun 2005; 25 (Suppl. 1): 63-68.
2. Ortonne J-P. Vitiligo and other disorders of hypopigmentation. In: Bolognia JL, Jorizzo JL, Rapini RP, Horn TD, Mascaro JM, Saurat J-H, Mancini AJ, Salasche SJ, Stingl G, eds. Dermatology, Vol. 1, 1st edn. Mosby, Edinburgh, 2003: 947-973.
3. Zhang XJ, Chen JJ, Liu JB. The genetic concept of vitiligo. J Dermatol Sci 2005; 39: 137-146.
4. Le Poole IC, Das PK, van den Wijngaard RM, Bos JD, Westerhof W. Review of the etiopathomechanism of vitiligo: A convergence theory. Exp Dermatol 1993; 2: 145-153.
5. Ogg GS, Rod Dunbar P, Romero P, Chen JL, Cerundolo V. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J Exp Med 1998; 188: 1203-1208.
6. Schallreuter KU. A review of recent advances on the regulation of pigmentation in the human epidermis. Cell Mol Biol (Noisy-le-Grand) 1999; 45: 943-949.
7. Maresca V, Roccella M, Roccella F et al. Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. J Invest Dermatol 1997; 109: 310-313.
8. Passi S, Grandinetti M, Maggio F, Stancato A, De Luca C. Epidermal oxidative stress in vitiligo. Pigment Cell Res 1998; 11: 81-85.
9. Dell'Anna ML, Maresca V, Briganti S, Camera E, Falchi M, Picardo M. Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligo. J Invest Dermatol 2001; 117: 908-913.
10. Giovannelli L, Bellandi S, Pitozzi V, Fabbri P, Dolara P, Moretti S. Increased oxidative DNA damage in mononuclear leukocytes in vitiligo. Mutat Res 2004; 556: 101-106.
11. Fenech M. The in vitro micronucleus technique. Mutat Res 2000; 455: 81-95.
12. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 2004; 195: 298-308.
13. Ferahbas A, Donmez-Altuntas H, Hamurcu Z, Aktas E, Utas S. Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients. Photodermatol Photoimmunol Photomed 2004; 20: 81-85.
14. Hamurcu Z, Demirtas H, Ascioglu O, Donmez-Altuntas H, Aktas E. Micronucleus evaluation in mitogen-stimulated lymphocytes of PUVA treated patients. Tohoku J Exp Med 2002; 198: 11-21.
15. Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res 1985; 147: 29-36.
16. Hamurcu Z, Donmez-Altuntas H, Borlu M, Demirtas H, Ascioglu O. Micronucleus frequency in the oral mucosa and lymphocytes of patients with Behcet's Disease. Clin Exp Dermatol 2005; 30: 565-569.
17. Au WW, Walker DM, Ward JB Jr, Whorton E, Legator MS, Singh V. Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Mutat Res 1991; 260: 137-144.
18. Crippa L, Gilardi S, Assimacopoulos A, Engel E. Sister chromatid exchange in patients affected by severe psoriasis. J Genet Hum 1983; 31 (Suppl. 5): 377-384.
19. Porciello G, Scarpato R, Storino F et al. The high frequency of spontaneous micronuclei observed in lymphocytes of systemic sclerosis patients: Preliminary results. Reumatismo 2002; 54: 36-39.
20. Porciello G, Scarpato R, Ferri C et al. Spontaneous chromosome damage (micronuclei) in systemic sclerosis and Raynaud's phenomenon. J Rheumatol 2003; 30: 1244-1247.
21. Migliore L, Bevilacqua C, Scarpato R. Cytogenetic study and FISH analysis in lymphocytes of systemic lupus erythematosus (SLE) and systemic sclerosis (SS) patients. Mutagenesis 1999; 14: 227-231.
22. Petcu I, Savu D, Thierens H, Nagels G, Vral A. In vitro radiosensitivity of peripheral blood lymphocytes in multiple sclerosis patients. Int J Radiat Biol 2006; 82: 793-803.
23. Ramos-Remus C, Dorazco-Barragan G, Aceves-Avila FJ et al. Genotoxicity assessment using micronuclei assay in rheumatoid arthritis patients. Clin Exp Rheumatol 2002; 20: 208-212.
24. Morhenn VB. Cell-mediated autoimmune diseases of the skin: Some hypotheses. Med Hypotheses 1997; 49: 241-245.
25. Badri AM, Todd PM, Garioch JJ, Gudgeon JE, Stewart DG, Goudie RB. An immunohistological study of cutaneous lymphocytes in vitiligo. J Pathol 1993; 170: 149-155.
26. Gunduz K, Ozturk G, Terzioglu E, Sebik F. T cell subpopulations and IL-2R in vitiligo. J Dermatol 2004; 31: 94-97.
27. Lang KS, Caroli CC, Muhm A et al. HLA-A2 restricted, melanocyte-specific CD8 (+) T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA/MART1. J Invest Dermatol 2001; 116: 891-897.
28. Steitz J, Bruck J, Lenz J, Buchs S, Tuting T. Peripheral CD8+ T cell tolerance against melanocytic self-antigens in the skin is regulated in two steps by CD4+ T cells and local inflammation: Implications for the pathophysiology of vitiligo. J Invest Dermatol 2005; 124: 144-150.
29. Chow S, Rizzo C, Ravitskiy L, Sinha AA. The role of T cells in cutaneous autoimmune disease. Autoimmunity 2005; 38: 303-317.
30. Schallreuter KU, Tobin DJ, Panske A. Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed Caucasian patients with vitiligo. Dermatology 2002; 204: 194-201.