Functional saponins in tea flower (flower buds of Camellia sinensis): Gastroprotective and hypoglycemic effects of floratheasaponins and qualitative and quantitative analysis using HPLC

Yakugaku Zasshi

Volumn 128, Issue 1, 2008, Pages 141-151

  Yoshikawa, Masayuki ^a   Wang, Tao ^a   Sugimoto, Sachiko ^a   Nakamura, Seikou ^a   Nagatomo, Akifumi ^a   Matsuda, Hisashi ^a   Harima, Shoichi ^b  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Harima Kampo Co Ltd   (Japan)

Author keywords

Camellia sinensis; Floratheasaponins; Gastroprotective effect; Hypoglycemic effect; Quantitative HPLC analysis; Tea flower

Indexed keywords

ALCOHOL; ALDEHYDE REDUCTASE; ALPHA GLUCOSIDASE; CAFFEINE; FLORATHEASAPONIN; FLORATHEASAPONIN A; FLORATHEASAPONIN B; FLORATHEASAPONIN C; FLORATHEASAPONIN D; FLORATHEASAPONIN E; FLORATHEASAPONIN F; GLUCOSE; INDOMETACIN; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; FLOWER; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDIA; JAPANESE; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; STOMACH MUCOSA LESION; TEA;

ANIMALS; CAMELLIA SINENSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLOWERS; HYPERGLYCEMIA; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SAPONINS; STOMACH ULCER;

EID: 38349016429     PISSN: 00316903     EISSN: 13475231     Source Type: Journal    
DOI: 10.1248/yakushi.128.141     Document Type: Article

References (44)

1. This paper is number XVIII in our series from medicinal flower studies. Medicinal Flower XVII: New Dammarane-Type Triterpene Glycosides from Flower Buds of American Ginseng, Panax quinquefoliuml. Nakamura S., Sugimoto S., Matsuda H., Yoshikawa M., Chem. Pharm. Bull., 55, 1342-1348 (2007).
2. Yoshikawa M., Shokuhin to Kagaku, 43, 40-42 (2001).
3. Yosioka I., Nishimura T., Matsuda A., Kitagawa I., Tetrahedron Lett., 5973-5978 (1966).
4. Tschesche R., Weber A., Wulff G., Justus Liebigs Ann. Chem., 721, 209-219 (1969).
5. Tsukamoto S., Kanegae T., Nagoya T., Shimamura M., Kato T., Watanabe S., Kawaguchi M., Alcohol Alcohol., 28, 687-692 (1993).
6. Sagesaka Y., Uemura T., Suzuki Y., Sugiura T., Yoshida M., Yamaguchi K., Kyuki K., Yakugaku Zasshi, 116, 238-243 (1996).
7. Sagesaka Y., Sugiura T., Miwa Y., Yamaguchi K., Kyuki K., Yakugaku Zasshi, 116, 388-395 (1996).
8. Kitagawa I., Hori K., Motozawa T., Murakami T., Yoshikawa M., Chem. Pharm. Bull., 46, 1901-1906 (1998).
9. Murakami T., Nakamura J., Matsuda H., Yoshikawa M., Chem. Pharm. Bull., 47, 1759-1764 (1999).
10. Murakami T., Nakamura J., Kageura T., Matsuda H., Yoshikawa M., Chem. Pharm. Bull., 48, 1720-1725 (2000).
11. Yoshikawa M., Morikawa T., Li N., Nagatomo A., Li X., Matsuda H., Chem. Pharm. Bull., 53, 1559-1564 (2005).
12. Morikawa T., Matsuda H., Li N., Nakamura S., Li X., Yoshikawa M., Heterocycles, 68, 1139-1148 (2006).
13. Morikawa T., Li N., Nagatomo A., Matsuda H., Li X., Yoshikawa M., J. Nat. Prod., 69, 185-190 (2006).
14. Yoshikawa M., Morikawa T., Nakamura S., Li N., Li X., Matsuda H., Chem. Pharm. Bull., 55, 57-63 (2007).
15. Li N., Morikawa T., Matsuda H., Ninomiya K., Li X., Yoshikawa M., Heterocycles, 71, 1193-1201 (2007).
16. Morikawa T., Nakamura S., Kato Y., Muraoka O., Matsuda H., Yoshikawa M., Chem. Pharm. Bull., 55, 293-298 (2007).
17. Shimada S., Nagasawa Y., Komatsubara N., Watanabe H., Ishii Y., "Ninon no Syokuseikatsu Zensyu 32, Hirakisho, Shimane no Shokuji," Nousangyosonbunkakyoukai, Tokyo, 1991, pp. 327-328.
18. Higuchi K., Tanabe S., Watanabe H., "Supervised, Aji no Furusato 12, Shimane no Aji," Kadokawa Shoten, Tokyo, 1978, pp. 13, 31.
19. Yoshikawa M., Shokuhin to Kagaku, 49, 25-28 (2007).
20. Yoshikawa M., "Supervised, Development of Medicinal Foods," CMC Publishers, Tokyo, 2007, pp. 103-109.
21. Yoshikawa M., Morikawa T., Murakami T., Toguchida I., Harima S., Matsuda H., Chem. Pharm. Bull., 47, 340-345 (1999).
22. Yoshikawa M., Morikawa T., Toguchida I., Harima S., Matsuda H., Chem. Pharm. Bull., 48, 651-656 (2000).
23. Matsuda H., Morikawa T., Toguchida I., Harima S., Yoshikawa M., Chem. Pharm. Bull., 50, 972-975 (2002).
24. Yoshikawa M., Murakami T., Kishi A., Kageura T., Matsuda H., Chem. Pharm. Bull., 49, 863-870 (2001).
25. Murakami T., Kishi A., Yoshikawa M., Chem. Pharm. Bull., 49, 974-978 (2001).
26. Matsuda H., Ninomiya K., Shimoda H., Yoshikawa M., Bioorg. Med. Chem., 10, 707-712 (2002).
27. Yoshikawa M., Murakami T., Ishiwada T., Morikawa T., Kagawa M., Higashi Y., Matsuda H., J. Nat. Prod., 65, 1151-1155 (2002).
28. Matsuda H., Morikawa T., Ishiwada T., Managi H., Kagawa M., Higashi Y., Yoshikawa M., Chem. Pharm. Bull., 51, 440-443 (2003).
29. Yoshikawa M., Morikawa T., Kashima Y., Ninomiya K., Matsuda H., J. Nat. Prod., 66, 922-927 (2003).
30. Matsuda H., Morikawa T., Ohgushi T., Ishiwada T., Nishida N., Yoshikawa M., Chem. Pharm. Bull., 53, 387-392 (2005).
31. Yoshikawa M., Morikawa T., Fujiwara E., Ohgushi T., AsaoY., Matsuda H., Heterocycles, 55, 1653-1658 (2001).
32. Yoshikawa M., Morikawa T., Asao Y., Fujiwara E., Nakamura S., Matsuda H., Chem. Pharm. Bull., 55, 606-612 (2007).
33. Yoshikawa M., Sugimoto S., Nakamura S., Matsuda H., Chem. Pharm. Bull., 55, 571-576 (2007).
34. Nakamura S., Sugimoto S., Matsuda H., Yoshikawa M., Heterocycles, 71, 577-588 (2007).
35. Yoshikawa M., Sugimoto S., Nakamura S., Sakumae H., Matsuda H., Chem. Pharm. Bull., 55, 1034-1038 (2007).
36. Yoshikawa M., Xu F., Morikawa T., Pongpiriyadacha Y., Nakamura S., Asao Y., Kumahara A., Matsuda H., Chem. Pharm. Bull., 55, 308-316 (2007).
37. Yoshikawa M., Morikawa T., Yamamoto K., Kato Y., Nagatomo A., Matsuda H., J. Nat. Prod., 68, 1360-1365 (2005).
38. Yoshikawa M., Nakamura S., Kato Y., Matsuhira K., Matsuda H., Chem. Pharm. Bull., 55, 598-605 (2007).
39. Yoshikawa M., Nakamura S., Sugimoto S., Kato Y., Wang T., Matsuda H., Chem. Pharm. Bull. (to be published).
40. Matsuda H., Yutana P., Morikawa T., Kishi A., Kataoka S., Yoshikawa M., Bioorg. Med. Chem. Lett., 13, 1101-1106 (2003).
41. Matsuda H., Ochi M., Nagatomo A., Yoshikawa M., Eur. J. Pharmacol., 561, 172-181 (2007).
42. Yoshikawa M., Pongpiriyadacha Y., Kishi A., Kageura T., Wang T., Morikawa T., Matsuda H., Yakugaku Zasshi, 123, 871-880 (2003).
43. Ding M., Yang H., Xiao S., J. Chromatogr. A., 23, 637-640 (1999).
44. Liang M., Pu S., Sun R., Chin. Tea, 24, 16-17 (2002).