Inhibition of tubulin polymerization by select alkenyldiarylmethanes

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 469-473

  Cullen, Matthew D ^a   Sarkar, Taradas ^b   Hamel, Ernest ^b   Hartman, Tracy L ^c   Watson, Karen M ^c   Buckheit Jr , Robert W ^c   Pannecouque, Christophe ^d   De Clercq, Erik ^d   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b Developmental Therapeutics Program   (United States)

^c ImQuest Biosciences   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

ADAM; Alkenyldiarylmethane; Anti HIV; Anticancer; Antiviral; Cytotoxicity; HIV; Tubulin

Indexed keywords

CC 5079; COLCHICINE; CYTOTOXIC AGENT; METHANE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TUBULIN POLYMERIZATION INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DIAGNOSTIC VALUE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; INHIBITION KINETICS; MICROTUBULE ASSEMBLY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BIOPOLYMERS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HIV REVERSE TRANSCRIPTASE; HUMANS; METHANE; REVERSE TRANSCRIPTASE INHIBITORS; TUBULIN;

EID: 38349013226     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.114     Document Type: Article

References (25)

1. AIDS Epidemic Update, December 2006; Joint United Nations Programme on HIV/AIDS (UNAIDS): Geneva, 2006; pp 1-98.
2. Gotte M., Kameoka M., McLellan N., Cellai L., and Wainberg M.A. J. Biol. Chem. 276 (2001) 6711
3. Kerr S.G., and Anderson K.S. Biochemistry 36 (1997) 14056
4. Kati W.M., Johnson K.A., Jerva L.F., and Anderson K.S. J. Biol. Chem. 267 (1992) 25988
5. Cushman M., Golebiewski M., Buckheit Jr. R.W., Graham L., and Rice W.G. Bioorg. Med. Chem. Lett. 5 (1995) 2713
6. Cushman M., Golebiewski W.M., Graham L., Turpin J.A., Rice W.G., Fliakas-Boltz V., and Buckheit Jr. R.W. J. Med. Chem. 39 (1996) 3217
7. Casimiro-Garcia A., Micklatcher M., Turpin J.A., Stup T.L., Watson K., Buckheit R.W., and Cushman M. J. Med. Chem. 42 (1999) 4861
8. Xu G., Micklatcher M., Silvestri M.A., Hartman T.L., Burrier J., Osterling M.C., Wargo H., Turpin J.A., Buckheit Jr. R.W., and Cushman M. J. Med. Chem. 44 (2001) 4092
9. Unpublished results, 2006.
10. Muller, G. W.; Man, H. -W. US 2006052596, 2006.
11. Zhang L.-H., Wu L., Raymon H.K., Chen R.S., Corral L., Shirley M.A., Narla R.K., Gamez J., Muller G.W., Stirling D.I., Bartlett J.B., Schafer P.H., and Payvandi F. Cancer Res. 66 (2006) 951
12. Jordan M.A., Hadfield J.A., Lawrence N.J., and McGown A.T. Med. Res. Rev. (1998) 18
13. Downing K.H. Annu. Rev. Cell. Dev. Biol. 16 (2000) 89
14. Hait W.N., Rubin E., and Goodin S. Cancer Chemother. Biol. Response Modif. 21 (2003) 41
15. Giacca M. Retrovirology (2005) 7
16. Cullen M.D., Deng B., Hartman T.L., Watson K.M., Buckheit Jr. R.W., Pannecouque C., De Clercq E., and Cushman M.S. J. Med. Chem. 50 (2007) 4854
17. Sakamoto T., Cullen M.D., Hartman Tracy L., Watson K.M., Buckheit Robert W., Pannecouque C., De Clercq E., and Cushman M. J. Med. Chem. 50 (2007) 3314
18. Deng B.-L., Hartman T.L., Buckheit Jr. R.W., Pannecouque C., De Clercq E., Fanwick P.E., and Cushman M. J. Med. Chem. 48 (2005) 6140
19. 19,20
20. Hamel E., and Lin C.M. Biochemistry 23 (1984) 4173
21. Hamel E. Cell Biochem. Biophys. 38 (2003) 1
22. Silvestri M.A., Nagarajan M., De Clercq E., Pannecouque C., and Cushman M. J. Med. Chem. 47 (2004) 3149
23. Rice W.G.B., and Bader J.P. Adv. Pharmacol. (San Diego) 33 (1995) 389
24. Pauwels R., Baba M., Snoeck R., Schols D., Herdewijn P., Desmyter J., and De Clercq E. J. Virol. Methods 20 (1988) 309
25. Hargrave K.D., Proudfoot J.R., Grozinger K., Cullen E., Kapadia S.R., Patel U.R., Fuchs V.U., Mauldin S.C., Vitous J., Behnke M.L., Klunder J.M., Plal K., Skiles J.W., McNeil D.W., Rose J.M., Chow G.C., Skoog M.T., Wu J.C., Schmidt G., Engel W.W., Eberlein W.G., Saboe T.D., Campbell S.J., Rosenthal A.S., and Adams J. J. Med. Chem. 34 (1991) 2231