Preserved orbitofrontal function in first-episode schizophrenia: Further evidence from the object alternation paradigm

Journal of Nervous and Mental Disease

Volumn 196, Issue 1, 2008, Pages 67-70

  González Blanch, César ^a   Vázquez Barquero, José Luis ^a   Carral Fernández, Laura ^a   Rodríguez Sánchez, José Manuel ^a   Álvarez Jiménez, Mario ^a,b   Crespo Facorro, Benedicto ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b ORYGEN RESEARCH CENTRE   (Australia)

Author keywords

Decision making; First episode; Object alternation; Orbitofrontal; Schizophrenia

Indexed keywords

ADULT; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; CORRELATION COEFFICIENT; DECISION MAKING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; ORBITAL CORTEX; RANK SUM TEST; SCHIZOPHRENIA;

ADULT; DECISION MAKING; DISCRIMINATION LEARNING; FEMALE; FRONTAL LOBE; GAMBLING; HUMANS; LONGITUDINAL STUDIES; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; ORIENTATION; PATTERN RECOGNITION, VISUAL; PERCEPTUAL MASKING; PSYCHOMOTOR PERFORMANCE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEMANTICS;

EID: 38349002911     PISSN: 00223018     EISSN: None     Source Type: Journal    
DOI: 10.1097/NMD.0b013e318160ea17     Document Type: Article

References (29)

1. Abbruzzese M, Ferri S, Scarone S (1997) The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: A double dissociation experimental finding. Neuropsychologia. 35:907-912.
2. Andreasen NC (1981) Scale for the Assessment of Negative Symptoms (SANS). Iowa City (IA): University of Iowa.
3. Andreasen NC (1983) Scale for the Assessment of Positive Symptoms (SAPS). Iowa City (IA): University of Iowa.
4. Andreasen NC, Flaum M, Arndt S (1992) The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry. 49:615-623.
5. Bark R, Dieckmann S, Bogerts B, Northoff G (2005) Deficit in decision making in catatonic schizophrenia: An exploratory study. Psychiatry Res. 134:131-141.
6. Beninger RJ, Wasserman J, Zanibbi K, Charbonneau D, Mangels J, Beninger BV (2003) Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: A double dissociation. Schizophr Res. 61:281-292.
7. Brewer WJ, Edwards J, Anderson V, Robinson T, Pantelis C (1996) Neuropsychological, olfactory and hygiene deficits in men with negative symptom schizophrenia. Biol Psychiatry. 40:1021-1031.
8. Brewer WJ, Pantelis C, Anderson V, Velakoulis D, Singh B, Copolov DL, McGorry PD (2001) Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis. Am J Psychiatry. 158:107-115.
9. Brewer WJ, Wood SJ, McGorry PD, Francey SM, Phillips LJ, Yung AR, Anderson V, Copolov DL, Singh B, Velakoulis D, Pantelis C (2003) Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J Psychiatry. 160:1790-1794.
10. Cavallaro R, Cavedini P, Mistretta P, Bassi T, Angelone SM, Ubbiali A, Bellodi L (2003) Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: a controlled, double dissociation study. Biol Psychiatry. 54:437-443.
11. Cavedini P, Zorzi C, Bassi T, Gorini A, Baraldi C, Ubbiali A, Bellodi L (2006) Decision-making functioning as a predictor of treatment outcome in anorexia nervosa. Psychiatry Res. 145:179-187.
12. Crespo-Facorro B, Perez-Iglesias R, Ramirez-Bonilla M, Martinez-Garcia O, Llorca J, Vazquez-Barquero JL (2006) A practical clinical trial comparing haloperidol, risperidone and olanzapine for the acute treatment of first-episode nonaffective psychosis. J Clin Psychiatry. 67:1511-1521.
13. First MB, Spitzer RL, Gibbon M, Williams JBW (1995) Structured Clinical Interview for DSM-IV Axis I Disorders. New York: Biometrics Research Department, New York State Psychiatric Institute.
14. Freedman M (1990) Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease. Brain Cogn. 14:134-143.
15. Freedman M, Black S, Ebert P, Binns M (1998) Orbitofrontal function, object alternation and perseveration. Cereb Cortex. 8:18-27.
16. González-Blanch C, Crespo-Facorro B, Álvarez-Jiménez M, Rodríguez-Sánchez J, Pelayo-Terán JM, Pérez-Iglesias R, Vázquez-Barquero JL (2007) Cognitive dimensions in first-episode schizophrenia spectrum disorders. J Psychiatr Res. 41:968-977.
17. Good KP, Whitehorn D, Rui Q, Milliken H, Kopala LC (2006) Olfactory identification deficits in first-episode psychosis may predict patients at risk for persistent negative and disorganized or cognitive symptoms. Am J Psychiatry. 163:932-933.
18. Hutton SB, Murphy FC, Joyce EM, Rogers RD, Cuthbert I, Barnes TR, McKenna PJ, Sahakian BJ, Robbins TW (2002) Decision making deficits in patients with first-episode and chronic schizophrenia. Schizophr Res. 55:249-257.
19. Kuelz AK, Riemann D, Zahn R, Voderholzer U (2004) Object alternation test - Is it sensitive enough to detect cognitive dysfunction in obsessive-compulsive disorder? Eur Psychiatry. 19:441-443.
20. Moberg PJ, Doty RL, Turetsky BI, Arnold SE, Mahr RN, Gur RC, Bilker W, Gur RE (1997) Olfactory identification deficits in schizophrenia: correlation with duration of illness. Am J Psychiatry. 154:1016-1018.
21. Pantelis C, Brewer W (1995) Neuropsychological and olfactory dysfunction in schizophrenia: Relationship of frontal syndromes to syndromes of schizophrenia. Schizophr Res. 17:35-45.
22. Ritter LM, Meador-Woodruff JH, Dalack GW (2004) Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophr Res. 68:65-73.
23. Rodriguez-Sanchez JM, Crespo-Facorro B, Perez-Iglesias R, González-Blanch C, Alvarez-Jimenez M, Llorca J, Vazquez-Barquero JL (2005) Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: A dissociation between dorsolateral and orbitofrontal functioning. Schizophr Res. 77:279-288.
24. Seidman LJ, Goldstein JM, Goodman JM, Koren D, Turner WM, Faraone SV, Tsuang MT (1997) Sex differences in olfactory identification and Wisconsin Card Sorting performance in schizophrenia: Relationship to attention and verbal ability. Biol Psychiatry. 42:104-115.
25. Seidman LJ, Oscar-Berman M, Kalinowski AG, Ajilore O, Kremen WS, Faraone SV, Tsuang MT (1995) Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia. Neuropsychology. 9:481-490.
26. Sevy S, Burdick KE, Visweswaraiah H, Abdelmessih S, Lukin M, Yechiam E, Bechara A (2007) Iowa Gambling Task in schizophrenia: A review and new data in patients with schizophrenia and co-occurring cannabis use disorders. Schizophr Res. 92:74-84.
27. Shurman B, Horan WP, Nuechterlein KH (2005) Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophr Res. 72:215-224.
28. Wechsler D (1999) Wechsler Adult Intelligence Scale-III. Madrid: TEA Ediciones.
29. Wilder KE, Weinberger DR, Goldberg TE (1998) Operant conditioning and the orbitofrontal cortex in schizophrenic patients: Unexpected evidence for intact functioning. Schizophr Res. 30:169-174.