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Volumn 146, Issue 1-3, 2008, Pages 46-57

Pre-clinical evaluation of a new orally-active CCK-2R antagonist, Z-360, in gastrointestinal cancer models

Author keywords

Antagonist; Cholecystokinin (CCK) 2 gastrin receptor; Gastrin; Gemcitabine; Pancreatic carcinoma; Xenograft; Z 360

Indexed keywords

CALCIUM; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CISPLATIN; FLUOROURACIL; FOLINIC ACID; GASTRIN 17; GEMCITABINE; IODINE 125; PROTEIN KINASE B; UNCLASSIFIED DRUG; Z 360;

EID: 38149139407     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.08.007     Document Type: Article
Times cited : (19)

References (41)
  • 1
    • 0034805363 scopus 로고    scopus 로고
    • The CCK-2 receptor is located on the ECL cell, but not on the parietal cell
    • Bakke I., Qvigstad G., Sandvik A.K., and Waldum H.L. The CCK-2 receptor is located on the ECL cell, but not on the parietal cell. Scand J Gastroenterol 36 (2001) 1128-1133
    • (2001) Scand J Gastroenterol , vol.36 , pp. 1128-1133
    • Bakke, I.1    Qvigstad, G.2    Sandvik, A.K.3    Waldum, H.L.4
  • 3
    • 0036971071 scopus 로고    scopus 로고
    • Cellular localization of cholecystokinin receptors as the molecular basis of the periperal regulation of acid secretion
    • Schmidt W.E., and Schmitz F. Cellular localization of cholecystokinin receptors as the molecular basis of the periperal regulation of acid secretion. Pharmacol Toxicol 91 (2002) 351-358
    • (2002) Pharmacol Toxicol , vol.91 , pp. 351-358
    • Schmidt, W.E.1    Schmitz, F.2
  • 4
    • 0034714887 scopus 로고    scopus 로고
    • Gastrin as a growth factor in the gastrointestinal tract
    • Koh T.J., and Chen D. Gastrin as a growth factor in the gastrointestinal tract. Regul Pept 93 (2000) 37-44
    • (2000) Regul Pept , vol.93 , pp. 37-44
    • Koh, T.J.1    Chen, D.2
  • 6
    • 0035074774 scopus 로고    scopus 로고
    • Expression of gastrin in developing gastric adenocarcinoma
    • Henwood M., Clarke P.A., Smith A.M., and Watson S.A. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg 88 (2001) 564-568
    • (2001) Br J Surg , vol.88 , pp. 564-568
    • Henwood, M.1    Clarke, P.A.2    Smith, A.M.3    Watson, S.A.4
  • 7
    • 4043152023 scopus 로고    scopus 로고
    • Human gastric tissues coexpress two different splicing cholecystokinin-B/gastrin receptors
    • Zhou J., Hu J., Chen Z., Wang W., Zhang Q., and Chen M. Human gastric tissues coexpress two different splicing cholecystokinin-B/gastrin receptors. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21 (2004) 440-443
    • (2004) Sheng Wu Yi Xue Gong Cheng Xue Za Zhi , vol.21 , pp. 440-443
    • Zhou, J.1    Hu, J.2    Chen, Z.3    Wang, W.4    Zhang, Q.5    Chen, M.6
  • 8
    • 1542615086 scopus 로고    scopus 로고
    • An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus
    • Harris J.C., Clarke P.A., Awan A., Jankowski J., and Watson S.A. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Res 64 (2004) 1915-1919
    • (2004) Cancer Res , vol.64 , pp. 1915-1919
    • Harris, J.C.1    Clarke, P.A.2    Awan, A.3    Jankowski, J.4    Watson, S.A.5
  • 9
    • 0034213130 scopus 로고    scopus 로고
    • Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma
    • Goetze J.P., Nielsen F.C., Burcharth F., and Rehfeld J.F. Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 88 (2000) 2487-2494
    • (2000) Cancer , vol.88 , pp. 2487-2494
    • Goetze, J.P.1    Nielsen, F.C.2    Burcharth, F.3    Rehfeld, J.F.4
  • 11
    • 0030762567 scopus 로고    scopus 로고
    • Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma
    • Weinberg D.S., Ruggeri B., Barber M.T., Biswas S., Miknyocki S., and Waldman S.A. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. J Clin Invest 100 (1997) 597-603
    • (1997) J Clin Invest , vol.100 , pp. 597-603
    • Weinberg, D.S.1    Ruggeri, B.2    Barber, M.T.3    Biswas, S.4    Miknyocki, S.5    Waldman, S.A.6
  • 12
    • 0030798118 scopus 로고    scopus 로고
    • The human gastrin/cholecystokinin receptors: type B and type C expression in colonic tumors and cell lines
    • Biagini P., Monges G., Vuaroqueaux V., Parriaux D., Cantaloube J.F., and De Micco P. The human gastrin/cholecystokinin receptors: type B and type C expression in colonic tumors and cell lines. Life Sci 61 (1997) 1009-1018
    • (1997) Life Sci , vol.61 , pp. 1009-1018
    • Biagini, P.1    Monges, G.2    Vuaroqueaux, V.3    Parriaux, D.4    Cantaloube, J.F.5    De Micco, P.6
  • 13
    • 0026576667 scopus 로고
    • Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells
    • Frucht H., Gazdar A.F., Park J.A., Oie H., and Jensen R.T. Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. Cancer Res 52 (1992) 1114-1122
    • (1992) Cancer Res , vol.52 , pp. 1114-1122
    • Frucht, H.1    Gazdar, A.F.2    Park, J.A.3    Oie, H.4    Jensen, R.T.5
  • 15
    • 0024581428 scopus 로고
    • Clinical significance of gastrin receptors in human colon cancers
    • Upp Jr. J.R., Singh P., Townsend Jr. C.M., and Thompson J.C. Clinical significance of gastrin receptors in human colon cancers. Cancer Res 49 (1989) 488-492
    • (1989) Cancer Res , vol.49 , pp. 488-492
    • Upp Jr., J.R.1    Singh, P.2    Townsend Jr., C.M.3    Thompson, J.C.4
  • 16
    • 38149107799 scopus 로고    scopus 로고
    • Development of a specific RT-PCR method to detect expression of CCK-2 receptor isoforms
    • Grabowska A., Clarke P.A., and Watson S.A. Development of a specific RT-PCR method to detect expression of CCK-2 receptor isoforms. Regul Pept 122 (2004) A152
    • (2004) Regul Pept , vol.122
    • Grabowska, A.1    Clarke, P.A.2    Watson, S.A.3
  • 17
    • 0034644655 scopus 로고    scopus 로고
    • Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth
    • Hellmich M.R., Rui X.L., Hellmich H.L., Fleming R.Y., Evers B.M., and Townsend C.M. Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. J Biol Chem 275 (2000) 32122-32128
    • (2000) J Biol Chem , vol.275 , pp. 32122-32128
    • Hellmich, M.R.1    Rui, X.L.2    Hellmich, H.L.3    Fleming, R.Y.4    Evers, B.M.5    Townsend, C.M.6
  • 18
    • 0027043237 scopus 로고
    • Novel expression of gastrin (cholecystokinin-B) receptors in azaserine-induced rat pancreatic carcinoma: receptor determination and characterization
    • Zhou W., Povoski S.P., Longnecker D.S., and Bell Jr. R.H. Novel expression of gastrin (cholecystokinin-B) receptors in azaserine-induced rat pancreatic carcinoma: receptor determination and characterization. Cancer Res 52 (1992) 6905-6911
    • (1992) Cancer Res , vol.52 , pp. 6905-6911
    • Zhou, W.1    Povoski, S.P.2    Longnecker, D.S.3    Bell Jr., R.H.4
  • 19
    • 38149008434 scopus 로고    scopus 로고
    • Characterising the proliferative, differentiative, and anti-apoptotic effects of gastrin; and the expression of sonic hedgehog - a potential differentiation factor - adjacent to the stem cell niche of the stomach
    • El-Zaatari M., and Watson S.A. Characterising the proliferative, differentiative, and anti-apoptotic effects of gastrin; and the expression of sonic hedgehog - a potential differentiation factor - adjacent to the stem cell niche of the stomach. Regul Pept 122 (2004) A151
    • (2004) Regul Pept , vol.122
    • El-Zaatari, M.1    Watson, S.A.2
  • 20
    • 33747879124 scopus 로고    scopus 로고
    • Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor
    • Dickson J.H., Grabowska A., El-Zaatari M., Atherton J., and Watson S.A. Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor. Cancer Res 66 (2006) 7524-7531
    • (2006) Cancer Res , vol.66 , pp. 7524-7531
    • Dickson, J.H.1    Grabowska, A.2    El-Zaatari, M.3    Atherton, J.4    Watson, S.A.5
  • 22
    • 14644442984 scopus 로고    scopus 로고
    • Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production
    • Colucci R., Blandizzi C., Tanini M., Vassalle C., Breschi M.C., and Del Tacca M. Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. Br J Pharmacol 144 (2005) 338-348
    • (2005) Br J Pharmacol , vol.144 , pp. 338-348
    • Colucci, R.1    Blandizzi, C.2    Tanini, M.3    Vassalle, C.4    Breschi, M.C.5    Del Tacca, M.6
  • 23
    • 33746056543 scopus 로고    scopus 로고
    • [A study of gastrin-focal adhesion kinase signal pathway in human colon cancer cells.]
    • Ding J., Yu J.P., Li D., Luo H.S., and Yu H.G. [A study of gastrin-focal adhesion kinase signal pathway in human colon cancer cells.]. Zhonghua Nei Ke Za Zhi 44 (2005) 434-437
    • (2005) Zhonghua Nei Ke Za Zhi , vol.44 , pp. 434-437
    • Ding, J.1    Yu, J.P.2    Li, D.3    Luo, H.S.4    Yu, H.G.5
  • 25
    • 0035292420 scopus 로고    scopus 로고
    • Distribution of 1,2 DMH-induced colonic aberrant crypt foci after administration of a gastrin receptor antagonist (CR2945), in the murine model
    • Fontana M.G., Ghirardi M., Moneghini D., La Pinta M., Villanacci V., Donato F., and Salerni B. Distribution of 1,2 DMH-induced colonic aberrant crypt foci after administration of a gastrin receptor antagonist (CR2945), in the murine model. Ann Ital Chir 72 (2001) 221-225
    • (2001) Ann Ital Chir , vol.72 , pp. 221-225
    • Fontana, M.G.1    Ghirardi, M.2    Moneghini, D.3    La Pinta, M.4    Villanacci, V.5    Donato, F.6    Salerni, B.7
  • 30
    • 0025192442 scopus 로고
    • The effect of the E2 prostaglandin enprostil, and the somatostatin analogue SMS 201 995, on the growth of a human gastric cell line, MKN45G
    • Watson S.A., Durrant L.G., and Morris D.L. The effect of the E2 prostaglandin enprostil, and the somatostatin analogue SMS 201 995, on the growth of a human gastric cell line, MKN45G. Int J Cancer 45 (1990) 90-94
    • (1990) Int J Cancer , vol.45 , pp. 90-94
    • Watson, S.A.1    Durrant, L.G.2    Morris, D.L.3
  • 32
    • 0031807848 scopus 로고    scopus 로고
    • Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines
    • McWilliams D.F., Watson S.A., Crosbee D.M., Michaeli D., and Seth R. Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines. Gut 42 (1998) 795-798
    • (1998) Gut , vol.42 , pp. 795-798
    • McWilliams, D.F.1    Watson, S.A.2    Crosbee, D.M.3    Michaeli, D.4    Seth, R.5
  • 33
    • 0037102094 scopus 로고    scopus 로고
    • mRNA-specific reverse transcription-polymerase chain reaction from human tissue extracts
    • Hurteau G.J., and Spivack S.D. mRNA-specific reverse transcription-polymerase chain reaction from human tissue extracts. Anal Biochem 307 (2002) 304-315
    • (2002) Anal Biochem , vol.307 , pp. 304-315
    • Hurteau, G.J.1    Spivack, S.D.2
  • 34
    • 16744368637 scopus 로고    scopus 로고
    • United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)
    • United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer 77 (1998) 1-10
    • (1998) Br J Cancer , vol.77 , pp. 1-10
  • 36
    • 0034667445 scopus 로고    scopus 로고
    • Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor
    • Watson S.A., Clarke P.A., Morris T.M., and Caplin M.E. Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. Cancer Res 60 (2000) 5902-5907
    • (2000) Cancer Res , vol.60 , pp. 5902-5907
    • Watson, S.A.1    Clarke, P.A.2    Morris, T.M.3    Caplin, M.E.4
  • 37
    • 0032737972 scopus 로고    scopus 로고
    • A comparison of the therapeutic effectiveness of gastrin neutralisation in two human gastric cancer models: relation to endocrine and autocrine/paracrine gastrin mediated growth
    • Watson S.A., Morris T.M., Varro A., Michaeli D., and Smith A.M. A comparison of the therapeutic effectiveness of gastrin neutralisation in two human gastric cancer models: relation to endocrine and autocrine/paracrine gastrin mediated growth. Gut 45 (1999) 812-817
    • (1999) Gut , vol.45 , pp. 812-817
    • Watson, S.A.1    Morris, T.M.2    Varro, A.3    Michaeli, D.4    Smith, A.M.5
  • 38
    • 22944473652 scopus 로고    scopus 로고
    • New approaches and therapeutics targeting apoptosis in disease
    • Fischer U., and Schulze-Osthoff K. New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev 57 (2005) 187-215
    • (2005) Pharmacol Rev , vol.57 , pp. 187-215
    • Fischer, U.1    Schulze-Osthoff, K.2
  • 39
    • 33645734079 scopus 로고    scopus 로고
    • Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin binding epidermal-like growth factor
    • Clarke P.A., Dickson J.H., Harris J.C., Grabowska A., and Watson S.A. Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin binding epidermal-like growth factor. Cancer Res 66 (2006) 3504-3512
    • (2006) Cancer Res , vol.66 , pp. 3504-3512
    • Clarke, P.A.1    Dickson, J.H.2    Harris, J.C.3    Grabowska, A.4    Watson, S.A.5
  • 40
    • 33750139635 scopus 로고    scopus 로고
    • The combine effects of proglumide and fluorouracil on the growth of murine Colon 38 cancer cells in vitro
    • Melen-Mucha G., Lawnicka H., and Mucha S. The combine effects of proglumide and fluorouracil on the growth of murine Colon 38 cancer cells in vitro. Endokrynol Pol 56 (2005) 933-938
    • (2005) Endokrynol Pol , vol.56 , pp. 933-938
    • Melen-Mucha, G.1    Lawnicka, H.2    Mucha, S.3
  • 41
    • 38149037446 scopus 로고    scopus 로고
    • Gastrin mediated XIAP up-regulation and associated cisplatin resistance in the pre-malignant and malignant oesophagus
    • Harris J.C., Clarke P., and Watson S.A. Gastrin mediated XIAP up-regulation and associated cisplatin resistance in the pre-malignant and malignant oesophagus. Gastroenterology 128 (2005) 301
    • (2005) Gastroenterology , vol.128 , pp. 301
    • Harris, J.C.1    Clarke, P.2    Watson, S.A.3


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