Neural Stem Cells Reduce Brain Injury After Unilateral Carotid Ligation

Pediatric Neurology

Volumn 38, Issue 2, 2008, Pages 86-92

  Comi, Anne M ^a,b   Cho, Eunpi ^b   Mulholland, Justin D ^a   Hooper, Andrew ^a   Li, Qun ^a,b   Qu, Yun ^a,b   Gary, Devin S ^a,b   McDonald, John W ^a,b   Johnston, Michael V ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN MATURATION; CAROTID ARTERY LIGATION; CELL SURVIVAL; CONTROLLED STUDY; HEMISPHERE; MALE; MORTALITY; MOUSE; NEURAL STEM CELL; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SEIZURE; STEM CELL TRANSPLANTATION; STROKE;

ANIMALS; ATROPHY; BRAIN ISCHEMIA; BRAIN NEOPLASMS; CAROTID ARTERIES; CELL SURVIVAL; LIGATION; MICE; NEURONS; SEIZURES; STEM CELL TRANSPLANTATION; STEM CELLS; STEREOTAXIC TECHNIQUES; STROKE; TERATOMA; TRETINOIN;

EID: 38149091867     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2007.10.007     Document Type: Article

References (26)

1. Lynch J.K., Hirtz D.G., DeVeber G., and Nelson K.B. Report of the National Institute of Neurological Disorders and Stroke Workshop on Perinatal and Childhood Stroke. Pediatrics 109 (2002) 116-123
2. Delsing B.J., Catsman-Berrevoets C.E., and Appel I.M. Early prognostic indicators of outcome in ischemic childhood stroke. Pediatr Neurol 24 (2001) 283-289
3. Koelfen W., Freund M., and Varnholt V. Neonatal stroke involving the middle cerebral artery in term infants: Clinical presentation, EEG and imaging studies, and outcome. Dev Med Child Neurol 37 (1995) 204-212
4. Comi A.M., Weisz C.J., Highet B.H., Johnston M.V., and Wilson M.A. A new model of stroke and ischemic seizures in the immature mouse. Pediatr Neurol 31 (2004) 254-257
5. Comi A.M., Highet B.H., Mehta P., Hana C.T., Johnston M.V., and Wilson M.A. Dextromethorphan protects male but not female mice with brain ischemia. Neuroreport 17 (2006) 1319-1322
6. Lynch J.K., and Nelson K.B. Epidemiology of perinatal stroke. Curr Opin Pediatr 13 (2001) 499-505
7. Keidan I., Shahar E., Barzilay Z., Passwell J., and Brand N. Predictors of outcome of stroke in infants and children based on clinical data and radiologic correlates. Acta Paediatr 83 (1994) 762-765
8. Bliss T., Guzman R., Daadi M., and Steinberg G.K. Cell transplantation therapy for stroke. Stroke 38 (2007) 817-826
9. Morrison R.S., Wenzel H.J., Kinoshita Y., Robbins C.A., Donehower L.A., and Schartzkroin P.A. Loss of the p53 tumor suppressor gene protects neurons against kainate-induced cell death. J Neurosci 16 (1996) 1337-1345
10. Hadjantonakis A.K., Gertsenstein M., Ikawa M., Okabe M., and Nagy A. Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech Dev 76 (1998) 79-90
11. Vadivelu S., Platik M.M., Choi L., et al. Multi-germ layer lineage CNS repair: Transplanted embryonic stem cells generate both nerve cells and vascular cells in the injured brain. J Neurosurg 103 (2005) 124-135
12. Kondziolka D., Steinberg G.K., Wechsler L., et al. Neurotransplantation for patients with subcortical motor stroke: A phase 2 randomized trial. J Neurosurg 103 (2005) 38-45
13. Nelson P.T., Kondziolka D., Wechsler L., et al. Clonal human (hNT) neuron grafts for stroke therapy: Neuropathology in a patient 27 months after implantation. Am J Pathol 160 (2002) 1201-1206
14. Savitz S.I., Dinsmore J., Wu J., Henderson G.V., Stieg P., and Caplan L.R. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study. Cerebrovasc Dis 20 (2005) 101-107
15. Lepore A.C., Neuhuber B., Connors T.M., et al. Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience 142 (2006) 287-304
16. Zheng T., Rossignol C., Leibovici A., Anderson K.J., Steindler D.A., and Weiss M.D. Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Brain Res 1112 (2006) 99-105
17. Park K.I., Teng Y.D., and Snyder E.Y. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol 20 (2002) 1111-1117
18. Qu S.Q., Luan Z., Yin G.C., et al. Transplantation of human fetal neural stem cells into cerebral ventricle of the neonatal rat following hypoxic-ischemic injury: Survival, migration and differentiation. [in Japanese]. Zhonghua Er Ke Za Zhi 43 (2005) 576-579
19. Park K.I., Himes B.T., Stieg P.E., Tessler A., Fischer I., and Snyder E.Y. Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Exp Neurol 199 (2006) 179-190
20. Yasuhara T., Matsukawa N., Yu G., et al. Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury. Cell Transplant 15 (2006) 231-238
21. Meier C., Middelanis J., Wasielewski B., et al. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatr Res 59 (2006) 244-249
22. Luan Z., Yin G.C., Hu X.H., et al. Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle. [in Japanese]. Zhonghua Er Ke Za Zhi 43 (2005) 580-583
23. Bieberich E., Silva J., Wang G., Krishnamurthy K., and Condie B.G. Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol 167 (2004) 723-734
24. Torihashi S., Kuwahara M., Ogaeri T., Zhu P., Kurahashi M., and Fujimoto T. Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation. Stem Cells 24 (2006) 2618-2626
25. Erdo F., Buhrle C., Blunk J., et al. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 23 (2003) 780-785
26. Dihne M., Bernreuther C., Hagel C., Wesche K.O., and Schachner M. Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain. Stem Cells 24 (2006) 1458-1466