Dextromethorphan protects male but not female mice with brain ischemia

NeuroReport

Volumn 17, Issue 12, 2006, Pages 1319-1322

  Comi, Anne M ^a,b   Highet, Bridget H ^a   Mehta, Paulomi ^a   Hana Chong, Tae ^a   Johnston, Michael V ^a   Ann Wilson, Mary ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

Carotid ligation; Dextromethorphan; Immature mouse; Ischemia; N methyl D aspartate receptor; Sex related neuroprotection

Indexed keywords

DEXTROMETHORPHAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; EXPERIMENTAL MODEL; FEMALE; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SEX DIFFERENCE;

ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; DEXTROMETHORPHAN; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; NEUROPROTECTIVE AGENTS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 33748361591     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000220136.98918.41     Document Type: Article

References (20)

1. Thorvaldsen P, Kuulasmaa K, Rajakangas AM, Rastenyte D, Sarti C, Wilhelmsen L. Stroke trends in the WHO MONICA project. Stroke 1997; 28:500-506.
2. Wyller TB. Stroke and gender. J Gend Specif Med 1999; 2:41-45.
3. Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke 2005; 36:62-65.
4. Golomb MR, Dick PT, MacGregor DL, Curtis R, Sofronas M, deVeber G. Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. J Child Neurol 2004; 19:493-497.
5. Fullerton HJ, Wu YW, Zhao S, Johnston SC. Risk of stroke in children: ethnic and gender disparities. Neurology 2003; 61:189-194.
6. deVeber GA, MacGregor D, Curtis R, Mayank S. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 2000; 15:316-324.
7. Comi AM, Weisz CJ, Highet BH, Johnston MV, Wilson MA. A new model of stroke and ischemic seizures in the immature mouse. Pediatr Neurol 2004; 31:254-257.
8. Comi AM, Johnston MV,Wilson MA. Strain variability, injury distribution and seizure onset in a mouse model of stroke in the immature brain. Dev Neurosci 2005; 27:127-133.
9. Prince DA, Feeser HR. Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia. Neurosci Lett 1988; 85:291-296.
10. Palmer GC. Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Curr Drug Targets 2001; 2:241-271.
11. Morrison RS, Wenzel HJ, Kinoshita Y, Robbins CA, Donehower LA, Schwartzkroin PA. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J Neurosci 1996; 16:1337-1345.
12. Matsushita H, Johnston MV, Lange MS, Wilson MA. Protective effect of erythropoietin in neonatal hypoxic ischemia in mice. Neuroreport 2003; 14:1757-1761.
13. Paxinos G, Franklin KBJ. The mouse brain in stereotaxic coordinates. San Diego, California: Academic Press; 2001.
14. Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, et al. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem 2004; 279:38563-38570.
15. Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998; 19:287-298.
16. Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M, et al. PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. J Neurochem 2004; 90:1068-1075.
17. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab 2005; 25:502-512.
18. Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y, Blomgren K, Hagberg H. Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem. 2006; 96:1016-1027.
19. Ramachander G, Bapatla KR, Emele JF. Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan. J Pharm Sci 1978; 67:1326-1327.
20. Schlenker EH. Dextromethorphan affects ventilation differently in male and female rats. J Appl Physiol 1996; 81:1911-1916.