Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a pre-barrett's esophagus setting

Journal of Gastrointestinal Surgery

Volumn 12, Issue 1, 2008, Pages 2-9

  Miyashita, Tomoharu ^a   Shah, Furhawn A ^a   Marti, Guy ^a   Wang, Jiaai ^a   Armstrong, Todd ^a   Bonde, Pramod ^a   Gibson, Michael K ^a   Yoshimura, Kiyoshi ^a   Montgomery, Elizabeth A ^a   Duncan, Mark D ^a   Jaffee, Elizabeth M ^a   Harmon, John W ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Barrett's esophagus; Esophageal cancer; GM CSF; Vaccine

Indexed keywords

CANCER VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADENOCARCINOMA; ANIMAL; ARTICLE; BARRETT ESOPHAGUS; COMPARATIVE STUDY; ESOPHAGOSTOMY; ESOPHAGUS TUMOR; EXPERIMENTAL NEOPLASM; FOLLOW UP; GASTRECTOMY; ILEOSTOMY; IMMUNOLOGY; PATHOLOGY; RAT; REFLUX ESOPHAGITIS; SPRAGUE DAWLEY RAT; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; BARRETT ESOPHAGUS; CANCER VACCINES; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; ESOPHAGITIS, PEPTIC; ESOPHAGOSTOMY; FOLLOW-UP STUDIES; GASTRECTOMY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; ILEOSTOMY; NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 38149017787     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-007-0337-2     Document Type: Article

References (13)

1. Byrnes CK, Bahadursingh A, Akhter N, Parinandi NL, Natarajan V, Montgomery E, Tihan T, Duncan MD, Nass PH, Harmon JW. Duodenal reflux produces hyperproliferative epithelial esophagitis-a possible precursor to esophageal adenocarcinoma in the rat. J Gastrointest Surg 2003;7:172-180.
2. Miwa K, Sahara H, Segawa M, Kinami S, Sato T, Miyazaki I, Hattori T. Reflux of duodenal or gastro-duodenal contents induces esophageal carcinoma in rats. Int J Cancer 1996;67:269-274.
3. Buttar NS, Wang KK, Leontovich O, Westcott JY, Pacifico RJ, Anderson MA, Krishnadath KK, Lutzke LS, Burgart LJ. Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. Gastroenterology 2002;122:1101-1112.
4. Bonde P, Sui G, Dhara S, Wang J, Broor A, Kim IF, Wiley JE, Marti G, Duncan M, Jaffee E, Montgomery E, Maitra A, Harmon JW. Cytogentic characterization and gene expression profiling in the rat reflux induced esophageal tumor model. J Thorac Cardiovasc Surg 2007;133:763-769.
5. Sui G, Bonde P, Dhara S, Broor A, Wang J, Marti G, Feldmann G, Duncan M, Montgomery E, Maitra A, Harmon JW. Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model. J Surg Res 2006;134:131-9.
6. Thomas MC, Greten TF, Pardoll DM, Jaffee EM. Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum Gene Ther 1998;9:835-843.
7. Jaffee EM, Hruban RH, Biedrzycki B, Laheru D, Schepers K, Sauter PR, Goemann M, Coleman J, Grochow L, Donehower RC, Lillemoe KD, O'Reilly S, Abrams RA, Pardoll DM, Cameron JL, Yeo CJ. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001;19:145-156.
8. Emens LA, Armstrong D, Biedrzycki B, Davidson N, Davis-Sproul J, Fetting J, Jaffee E, Onners B, Piantadosi S, Reilly RT, Stearns V, Tartakovsky I, Visvanathan K, Wolff A. A phase I vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyclophosphamide and doxorubicin. Hum Gene Ther 2004;15:313-337.
9. Simons JW, Jaffee EM, Weber CE, Levitsky HI, Nelson WG, Carducci MA, Lazenby AJ, Cohen LK, Finn CC, Clift SM, Hauda KM, Beck LA, Leiferman KM, Owens AH, Jr., Piantadosi S, Dranoff G, Mulligan RC, Pardoll DM, Marshall FF. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 1997;57:1537-1546.
10. Simons JW, Mikhak B, Chang JF, DeMarzo AM, Carducci MA, Lim M, Weber CE, Baccala AA, Goemann MA, Clift SM, Ando DG, Levitsky HI, Cohen LK, Sanda MG, Mulligan RC, Partin AW, Carter HB, Piantadosi S, Marshall FF, Nelson WG. Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer. Cancer Res 1999;59:5160-5168.
11. Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Cohen LK, Mulligan RC, Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998;95:13141-13146.
12. Miyashita T, Ohta T, Fujimura T, Ninomiya I, Fushida S, Hattori T, Miwa K. Duodenal juice stimulates oesophageal stem cells to induce Barrett's oesophagus and oesophageal adenocarcinoma in rats. Oncol Rep 2006;15:1469-1475.
13. Su Y, Chen X, Klein M, Fang M, Wang S, Yang CS, Goyal RK. Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus. Lab Invest 2004;84:753-765.