Pathogenic role of cardiac mast cell activation/degranulation, TNF-α, and cell death in acute drug-related fatalities

Vascular Health and Risk Management

Volumn 3, Issue 6, 2007, Pages 1053-1062

  Perskvist, Nasrin ^a   Söderberg, Carl ^a   van Hage, Marianne ^b   Edston, Erik ^a  

^a Department of Forensic Genetics and Forensic Toxicology   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Mast cells; Narcotic stimulant; Sudden death; TNF

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; AMPHETAMINE; BENZODIAZEPINE DERIVATIVE; BUPRENORPHINE; COCAINE; DEXTROPROPOXYPHENE; DIAMORPHINE; ETHYLMORPHINE; METHADONE; SEROTONIN UPTAKE INHIBITOR; STANOZOLOL; TETRAHYDROCANNABINOL; TRAMADOL; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; AORTA DISSECTION; APOPTOSIS; ARTICLE; AUTOPSY; CELL ACTIVATION; CELL DEATH; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ABUSE; DRUG FATALITY; DRUG INTOXICATION; ENZYME BLOOD LEVEL; FEMALE; HEART FAILURE; HEART MUSCLE CELL; HEROIN DEPENDENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; MAST CELL DEGRANULATION; NICK END LABELING; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUDDEN DEATH;

ADULT; APOPTOSIS; CASE-CONTROL STUDIES; CELL DEGRANULATION; DEATH, SUDDEN; FEMALE; FORENSIC PATHOLOGY; FORENSIC TOXICOLOGY; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; MALE; MAST CELLS; MIDDLE AGED; MUSCLE, SMOOTH; MYOCARDIUM; MYOCYTES, CARDIAC; RETROSPECTIVE STUDIES; SUBSTANCE-RELATED DISORDERS; TRYPTASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38149004740     PISSN: 11766344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Anker SD, Clark AL, Kemp M, et al. 1997. Tumor necrosis factor and steroid metabolism in chronic heart failure: possible relation to muscle wasting. J Am Coll Cardiol, 30(4):997-1001.
2. Blancke F, Claeys MJ, Jorens P, et al. 2005. Systemic inflammation and reperfusion injury in patients with acute myocardial infarction. Mediators Inflamm, 2005(6):385-9.
3. Edston E. 1997. Evaluation of agonal artefacts in the myocardium using a combination of histological stains and immunohistochemistry. Am J Forensic Med Pathol, 18(2):163-7.
4. Edston E, van Hage-Hamsten M. 1997. Anaphylactoid shock - a common cause of death in heroin addicts? Allergy, 52:950-4.
5. Edston E, Grontoft L, Johnsson J. 2002. TUNEL: a useful screening method in sudden cardiac death. Int J Legal Med, 116:22-6.
6. Edston E, Eriksson O, van Hage M. 2006. Mast cell tryptase in post-mortem serum-reference values and confounders. Int J Legal Med, 121(4):275-80.
7. Frangogiannis NG, Smith CW, Entman ML. 2002. The inflammatory response in myocardial infarction. Cardiovasc Res, 53(1):31-47.
8. Ferrari R, Bachetti T, Confortini F, et al. 1995. Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation, 92(6):1479-86.
9. Freude B, Masters TN, Robicsek F, et al. 2000. Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol, 32:197-208.
10. Gordon JR, Galli SJ. 1990. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature, 346(6281):274-6.
11. Irani AM, Bradford TR, Kepley CL, et al. 1989. Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem, 37:1509-15.
12. Kovanen PT, Kaartinen M, Paavonen T. 1995. Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rapture in myocardial infarction. Circulation, 92:1084-8.
13. Lessa MA, Tibirica E. 2006. Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl. Anesth Analg, 103(4):815-21.
14. Levine B, Kalman J, Mayer L, et al. 1990. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med, 323(4):236-41.
15. Linden J. 1994. Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci, 15(8):298-306.
16. Perskvist N, Edston E. 2006. Differential accumulation of pulmonary and cardiac mast cell-subsets and eosinophils between fatal anaphylaxis and asthma death. A postmortem comparative study. Forensic Sci Int, 169(1):43-9.
17. Rodriguez M, Schaper J. 2005. Apoptosis: measurement and technical issues. J Mol Cell Cardiol, 38:15-20.
18. Rossig L, Haendeler J, Mallat Z, et al. 2000. Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol. J Am Coll Cardiol, 36(7):2081-9.
19. Schwartz LB, Yunginger JW, Miller J, et al. 1989. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest, 83:1551-5.
20. Sherry B, Cerami A. 1988. Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J Cell Biol, 107(4):1269-77.
21. Somasundaram P, Ren G, Nagar H, et al. 2005. Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol, 205:102-11.
22. Tong W, Lima JA, Meng Q, et al. 2004. Long-term cocaine use is related to cardiac diastolic dysfunction in an African-American population in Baltimore, Maryland. Int J Cardiol, 97(1):25-8.
23. Torre-Amione G, Kapadia S, Lee J, et al. 1995. Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation, 92(6):1487-93.
24. van Haelst PL, Timmer JR, Crijns HJ, et al. 2001. No long-lasting or intermittent mast cell activation in acute coronary syndromes. Int J Cardiol, 78(1):75-80.
25. Vassalli P. 1992. The pathophysiology of tumor necrosis factors. Annu Rev Immunol, 10:411-52.
26. Yao L, Baltatzis S, Zafirakis P, et al. 2003. Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Ocul Immunol Inflamm, 11:211-22.
27. Zhang QY, Ge JB, Chen JZ, et al. 2006. Mast cell contributes to cardiomyocyte apoptosis after coronary microembolization. J Histochem Cytochem, 54(5):515-23.