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Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease
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Johnston N, Knight J, Dettmar PW, et al. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 2004; 114:2129-2134.
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Tezer MS, Kockar MC, Koçkar O, Celik A. Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression. Acta Otolaryngol 2006; 126:958-961. This very interesting article demonstrates the correlation between colonization of H. pylori in the stomach and degree of esophagitis with the severity of LPR.
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Tezer MS, Kockar MC, Koçkar O, Celik A. Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression. Acta Otolaryngol 2006; 126:958-961. This very interesting article demonstrates the correlation between colonization of H. pylori in the stomach and degree of esophagitis with the severity of LPR.
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Gastroesophageal reflux and sequelae of chronic tubotympanal disorders in children
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Velepic MM, Velepic MS, Starcevic R, et al. Gastroesophageal reflux and sequelae of chronic tubotympanal disorders in children. Acta Otolaryngol 2004; 124:914-917.
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Velepic, M.M.1
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Zalesska-Krecicka M, Krecicki T, Iwanczak B, et al. Laryngeal manifestations of gastroesophageal reflux disease in children. Acta Otolaryngol 2002; 122:306-310.
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Zalesska-Krecicka, M.1
Krecicki, T.2
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White DR, Heavner SB, Hardy SM, Prazma J. Gastroesophageal reflux and Eustachian tube dysfunction in an animal model. Laryngoscope 2002; 112:955-961.
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White, D.R.1
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Prazma, J.4
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Is gastric reflux a cause of otitis media with effusion in children?
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Tasker A, Dettmar PW, Panetti M, et al. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002; 112:1930-1934.
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Tasker, A.1
Dettmar, P.W.2
Panetti, M.3
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14
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33845919906
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Otitis media in adults as a symptom of gastroesophageal reflux
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This interesting paper demonstrates a relationship between pepsinogen content in middle ear effusion and LPR symptoms. It also includes a preliminary therapeutic test to reduce pepsinogen in middle ear effusion
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Sone M, Yamamuro Y, Hayashi H, et al. Otitis media in adults as a symptom of gastroesophageal reflux. Otolaryngol Head Neck Surg 2007; 136:19-22. This interesting paper demonstrates a relationship between pepsinogen content in middle ear effusion and LPR symptoms. It also includes a preliminary therapeutic test to reduce pepsinogen in middle ear effusion.
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Otolaryngol Head Neck Surg
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Sone, M.1
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Abd El-Fattah AM, Abdul Maksoud GA, Ramadan AS, et al. Pepsin assay: a marker for reflux in pediatric glue ear. Otolaryngol Head Neck Surg 2007; 136:464-470. This was the first study to prove a significant positive correlation between levels of pepsin/pepsinogen content in middle ear effusion and the number of LPR episodes as measured by dual-probe pH monitoring.
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Abd El-Fattah AM, Abdul Maksoud GA, Ramadan AS, et al. Pepsin assay: a marker for reflux in pediatric glue ear. Otolaryngol Head Neck Surg 2007; 136:464-470. This was the first study to prove a significant positive correlation between levels of pepsin/pepsinogen content in middle ear effusion and the number of LPR episodes as measured by dual-probe pH monitoring.
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16
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Chambers DW, Davis WE. Long term outcome analysis of functional endoscopic sinus surgery: correlation of symptoms with endoscopic examination findings and potential prognostic factors. Laryngoscope 1997; 107:504-510.
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Chambers, D.W.1
Davis, W.E.2
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Ulualp SO, Toohill RJ. Laryngopharyngeal reflux: state of the art diagnosis and treatment. Otolaryngol Clin North Am 2000; 33:785-801.
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DelJaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope 2005; 115:946-957.
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Holmes-Wright, C.N.3
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Chronic hoarseness secondary to gastroesophageal reflux disease: Documentation with 24-h ambulatory pH monitoring
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Wiener GJ, Koufman JA, Wu WC, et al. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol 1989; 84:1503-1508.
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Exclusion of pH artifacts is essential for hypopharyngeal pH monitoring
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This very interesting paper throws strong light on a significant number of pH artifacts during laryngopharyngeal pH monitoring. It demonstrates how small the actual yield of pH monitoring can be and directs us to consider its results carefully
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Harrell SP, Koopman J, Woosley S, Wo JM. Exclusion of pH artifacts is essential for hypopharyngeal pH monitoring. Laryngoscope 2007; 117:470-474. This very interesting paper throws strong light on a significant number of pH artifacts during laryngopharyngeal pH monitoring. It demonstrates how small the actual yield of pH monitoring can be and directs us to consider its results carefully.
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Laryngoscope
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Harrell, S.P.1
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Smit, C.F.1
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Evaluation of omeprazole in the treatment of reflux laryngitis: A prospective, placebo-controlled, randomized, double-blind study
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Noordzij JP, Khidr A, Evans BA, et al. Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 2001; 111:2147-2151.
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Noordzij JP, Khidr A, Desper E, et al. Correlation of pH probe-measured laryngopharyngeal reflux with symptoms and signs of reflux laryngitis. Laryngoscope 2002; 112:2192-2195.
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Vincent DA Jr, Garrett JD, Radionoff SL, et al. The proximal probe in esophageal pH monitoring: development of a normative database. J Voice 2000; 14:247-254.
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Ozturk O, Oz F, Karakullukcu B, et al. Hoarseness and laryngopharyngeal reflux: a cause and effect relationship or coincidence? Eur Arch Otorhinolaryngol 2006; 263:935-939.
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Ylitalo R, Lindestad PA, Ramel S. Symptoms, laryngeal findings, and 24-h pH monitoring in patients with suspected gastroesophago-pharyngeal reflux. Laryngoscope 2001; 111:1735-1741.
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Ylitalo, R.1
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Harrell S, Evans B, Goudy S, et al. Design and implementation of an ambulatory pH monitoring protocol in patients with suspected laryngopharyngeal reflux. Laryngoscope 2005; 115:89-92.
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Harrell, S.1
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Treatment of chronic posterior laryngitis with esomeprazole
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Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006; 116:254-260.
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Vaezi, M.F.1
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Stasney, C.R.3
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Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure
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Pandolfino JE, Schreiner MA, Lee TJ, et al. Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure. Am J Gastroenterol 2005; 100:1466-1476.
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Pandolfino, J.E.1
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0036342032
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Book DT, Rhee JS, Toohill RJ, Smith TL. Perspectives in laryngopharyngeal reflux: an international survey. Laryngoscope 2002; 112:1399-1406.
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Book DT, Rhee JS, Toohill RJ, Smith TL. Perspectives in laryngopharyngeal reflux: an international survey. Laryngoscope 2002; 112:1399-1406.
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Karkos PD, Benton J, Leong SC, et al. Trends in laryngopharyngeal reflux: a British ENT survey. Eur Arch Otorhinolaryngol 2007; 264:513-517. This interesting survey demonstrates the real ENT practice related to laryngopharyngeal reflux. It reveals the wide gap between research and practice.
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Karkos PD, Benton J, Leong SC, et al. Trends in laryngopharyngeal reflux: a British ENT survey. Eur Arch Otorhinolaryngol 2007; 264:513-517. This interesting survey demonstrates the real ENT practice related to laryngopharyngeal reflux. It reveals the wide gap between research and practice.
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37
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34247482292
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Reflux and laryngitis: A systematic review
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This very interesting critical review article analyses previous relevant studies carefully and meticulously. It raises much controversy about the clinical relevance and diagnostic importance of pH monitoring with regard to LPR
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Joniau S, Bradshaw A, Esterman A, Carney S. Reflux and laryngitis: a systematic review. Otolaryngol Head Neck Surg 2007; 136:686-692. This very interesting critical review article analyses previous relevant studies carefully and meticulously. It raises much controversy about the clinical relevance and diagnostic importance of pH monitoring with regard to LPR.
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Joniau, S.1
Bradshaw, A.2
Esterman, A.3
Carney, S.4
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38
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Vandenplas Y, Goyvaerts H, Helven R, Sacre-Smith L. Gastroesophageal reflux, as measured by 24-h pH monitoring in 509 healthy infants screened for risk of sudden infant death syndrome. Pediatrics 1991; 88:834-840.
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The validity and reliability of the reflux finding score (RFS)
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Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001; 111:1313-1317.
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, vol.111
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Belafsky, P.C.1
Postma, G.N.2
Koufman, J.A.3
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Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002; 16:274-277.
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Belafsky, P.C.1
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Wise SK, Wise JC, DelGaudio JM. Gastroesophageal reflux and laryngopharyngeal reflux in patients with sleep-disordered breathing. Otolaryngol Head Neck Surg 2006; 135:253-257.
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Kelchner LN, Horne J, Lee L, et al. Reliability of speech-language pathologist and otolaryngologist ratings of laryngeal signs of reflux in an asymptomatic population using the Reflux Finding Score. J Voice 2007; 21:92-100. This paper clearly demonstrates a need for greater consensus among professionals regarding the physical findings associated with LPR. It raises the importance of identifying the normal variations so that we may properly measure the abnormal ones.
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Kelchner LN, Horne J, Lee L, et al. Reliability of speech-language pathologist and otolaryngologist ratings of laryngeal signs of reflux in an asymptomatic population using the Reflux Finding Score. J Voice 2007; 21:92-100. This paper clearly demonstrates a need for greater consensus among professionals regarding the physical findings associated with LPR. It raises the importance of identifying the normal variations so that we may properly measure the abnormal ones.
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43
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33644689190
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Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux
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Qadeer MA, Swoger J, Milstein C, et al. Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux. Laryngoscope 2005; 115:1947-1952.
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Milstein, C.3
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44
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33645234361
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Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: A systematic review
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In this systematic review, the authors direct attention toward the lack of evidence of the common practice in treating laryngopharyngeal reflux empirically. They also critically analyse the currently used clinical diagnostic tools
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Karkos PD, Wilson JA. Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review. Laryngoscope 2006; 116:144-147. In this systematic review, the authors direct attention toward the lack of evidence of the common practice in treating laryngopharyngeal reflux empirically. They also critically analyse the currently used clinical diagnostic tools.
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Laryngoscope
, vol.116
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Karkos, P.D.1
Wilson, J.A.2
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Branski RC, Bhattacharyya N, Shapiro J. The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease. Laryngoscope 2002; 112:1019-1024.
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Branski, R.C.1
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Sen P, Georgalas C, Bhattacharyya N. A systematic review of the rule of proton pump inhibitors for symptoms of laryngopharyngeal reflux. Clin Otolaryngol 2006; 31:20-24.
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Sen, P.1
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47
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An effective management regimen for laryngeal granuloma caused by gastro-esophageal reflux: Combination therapy with suggestions for lifestyle modifications
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This short communication clarifies the importance of combining lifestyle modification with medical treatment to control laryngeal granuloma, a condition well known to be difficult to control both medically and surgically
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Tsunoda K, Ishimoto S, Suzuki M, et al. An effective management regimen for laryngeal granuloma caused by gastro-esophageal reflux: combination therapy with suggestions for lifestyle modifications. Acta Otolaryngol 2007; 127:88-92. This short communication clarifies the importance of combining lifestyle modification with medical treatment to control laryngeal granuloma, a condition well known to be difficult to control both medically and surgically.
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Acta Otolaryngol
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Tsunoda, K.1
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Laryngopharyngeal reflux: Prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response
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Park W, Hicks DM, Khandwala F, et al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope 2005; 115:1230-1238.
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Laryngoscope
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Park, W.1
Hicks, D.M.2
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DelGaudio JM, Waring JP. Empiric esomeprazole in the treatment of laryngopharyngeal reflux. Laryngoscope 2002; 113:598-601.
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Laryngoscope
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DelGaudio, J.M.1
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Belafsky PC, Postma GN, Koufman JA. Laryngopharyngeal reflux symptoms improve before changes in physical findings. Laryngoscope 2001; 111:979-981.
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Reichel O, Keller J, Rasp G, et al. Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-h pH monitoring. Otolaryngol Head Neck Surg 2007; 136:205-210. In this paper, the discrepancy between clinical diagnosis and pH monitoring in LPR patients is described. The discussion is well prepared and informative regarding the different treatment regimens using PPIs
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Reichel O, Keller J, Rasp G, et al. Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-h pH monitoring. Otolaryngol Head Neck Surg 2007; 136:205-210. In this paper, the discrepancy between clinical diagnosis and pH monitoring in LPR patients is described. The discussion is well prepared and informative regarding the different treatment regimens using PPIs.
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Medical position statement: Guidelines on the use of esophageal pH recording
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American Gastroenterology Association
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American Gastroenterology Association. Medical position statement: guidelines on the use of esophageal pH recording. Gastroenterology 1996; 110:1981.
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(1981)
Gastroenterology 1996
, pp. 110
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33847138673
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Chest, This is an interesting paper which draws attention to the possible role of non-acid reflux in cases of LPR which fail PPI treatment. This is a very important aspect of LPR which needs more studies
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Orr WC, Craddock A, Goodrich S. Acidic and nonacidic reflux during sleep under conditions of powerful acid suppression. Chest 2007; 131:460-465. This is an interesting paper which draws attention to the possible role of non-acid reflux in cases of LPR which fail PPI treatment. This is a very important aspect of LPR which needs more studies.
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(2007)
Acidic and nonacidic reflux during sleep under conditions of powerful acid suppression
, vol.131
, pp. 460-465
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Orr, W.C.1
Craddock, A.2
Goodrich, S.3
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