Is gastric reflux a cause of otitis media with effusion in children?

Laryngoscope

Volumn 112, Issue 11, 2002, Pages 1930-1934

  Tasker, Andrea ^a   Dettmar, Peter W ^b   Panetti, Marguerite ^c   Koufman, James A ^c   Birchall, John P ^c   Pearson, Jeffrey P ^c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b RECKITT BENCKISER   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Gastric juice; Gastroesophageal reflux; Otitis media with effusion; Pepsin

Indexed keywords

ALBUMIN; FIBRINOGEN; PEPSIN A; PEPSINOGEN;

ARTICLE; CHILD; EFFUSION; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROESOPHAGEAL REFLUX; HEARING IMPAIRMENT; HUMAN; MIDDLE EAR; MYRINGOTOMY; OTITIS MEDIA; PATHOGENESIS; PRIORITY JOURNAL; STOMACH JUICE;

ALBUMINS; CHILD; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOENZYME TECHNIQUES; OTITIS MEDIA WITH EFFUSION; PEPSIN A; PEPSINOGEN A; PROTEINS;

EID: 0036844007     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200211000-00004     Document Type: Article

References (14)

1. Paradise JL. Otitis media in infants and children. Pediatrics 1980;65:917-943.
2. Sade J. Middle ear mucosa. Arch Otolaryngol 1966;84:137-143.
3. Karver SB. Otitis media. Ear, Nose and Throat Disord 1998;25:619-632.
4. Faden H, Duffy L, Boeve M. Otitis media: Back to basics. Pediatr Infect Dis J 1998;17:1105-1113.
5. Poelmans J, Tack J, Feenstra L. Chronic middle ear disease and gastroesophageal reflux disease: A causal relation? Otol Neurotol 2001;22:447-450.
6. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101:1-78.
7. Shepherd RW, Wren J, Evans JWS, Lander M, Ong TH. Gastroesophageal reflux in children: Clinical profile, course and outcome with active therapy in 126 cases. Clin Pediatr 1987;26:55-60.
8. Bluestone CD, Beery QC, Andrus WS. Mechanics of the eustachian tube as it influences susceptibility to and persistence of middle ear effusions in children. Ann Otol Rhinol Laryngol Suppl 1974;83:27-34.
9. Wezyk MT, Makowski A. pH of fluid collected from middle ear in the course of otitis media in children. Otolaryngol Polska 2000;54:131-133.
10. Hutton DA, Allen A, Pearson JP, Ward R, Venables CW. Separation of pepsins in human gastric juice: Analysis of proteolytic and mucolytic activity. Biochem Soc Trans 1986;14:735-736.
11. Lin Y, Means GE, Feeney RE. The action of proteolytic enzymes on N, N-dimethyl proteins. J Biol Chem 1969;244:789-793.
12. Furihata C, Senma T, Saito D, Matsushima T, Sugimura T. A new fluorescent microassay method for pepsin using succinyl-albumin. Anal Biochem 1978;84:479-485.
13. Heavner SB, Hardy SM, White DR, Prazma J, Pillsbury HC III. Transient inflammatory and dysfunction of the eustachian tube secondary to multiple exposures of simulated gastroesophageal refluxant. Ann Otol Rhinol Laryngol 2001;110:928-934.
14. Shilkin R. Crying babies. Br J Gen Pract 1991;41:258.