Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors

Journal of Biological Chemistry

Volumn 282, Issue 52, 2007, Pages 37529-37536

  Perrin, Marilyn H ^a,b   Grace, Christy R R ^b   DiGruccio, Michael R ^a   Fischer, Wolfgang H ^a   Maji, Samir K ^b   Cantle, Jeffrey P ^a   Smith, Sean ^a   Manning, Gerard ^b   Vale, Wylie W ^a,d   Riek, Roland ^b,c  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c ETH ZURICH   (Switzerland)

^d Neurocrine Biosciences and Acceleron Pharma ^*

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE BOND; POLYPEPTIDE RECEPTORS;

ACTIVATION ANALYSIS; LIGANDS; NUCLEAR MAGNETIC RESONANCE; POLYPEPTIDES;

PROTEINS;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ARGININE; ASPARTIC ACID; ASTRESSIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2BETA; G PROTEIN COUPLED RECEPTOR; GROWTH HORMONE RELEASING FACTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; INCRETIN; MUTANT PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR INTERACTION; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARGININE; ASPARTIC ACID; CERCOPITHECUS AETHIOPS; CORTICOTROPIN-RELEASING HORMONE; COS CELLS; CYSTEINE; IMMUNOHISTOCHEMISTRY; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MUTAGENESIS; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SALTS;

EID: 38049153347     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703748200     Document Type: Article

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