Is Salamol less effective than Ventolin? A randomised, blinded, crossover study in New Zealand

New Zealand Medical Journal

Volumn 120, Issue 1267, 2007, Pages

  Chang, Catherina L ^a   Cooray, Manisha ^a   Mills, Graham ^a   Hancox, Robert J ^a  

^a WAIKATO HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BUDESONIDE; FLUTICASONE; METHACHOLINE; SALBUTAMOL; STEROID; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; GENERIC DRUG;

ACUTE DISEASE; ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG EFFICACY; DRUG RESPONSE; DRUG USE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION SPACER; MALE; METERED DOSE INHALER; NEW ZEALAND; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; COMPARATIVE STUDY; DRUG EFFECT; FOLLOW UP; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; ADULT; ALBUTEROL; ASTHMA; CROSS-OVER STUDIES; DRUGS, GENERIC; FEMALE; FOLLOW-UP STUDIES; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; NEW ZEALAND; PATIENT COMPLIANCE; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 38049144592     PISSN: None     EISSN: 11758716     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. The BTS/SIGN British Guideline on the Management of Asthma. Thorax 2003; Vol 58;Supplement I, April 2004 Update.
2. PHARMAC. New Zealand Pharmaceutical Schedule Update effective 1 July 2005. Wellington: PHARMAC; 2005.
3. Clark DJ, Gordon-Smith J, McPhate G, et al. Lung bioavailability of generic and innovator salbutamol metered dose inhalers. Thorax. 1996;51:325-6
4. Pinto Pericira LM, Clement YN, Pinto Pereiras SM. Comparison of innovator and generic salbutamol inhalers: A double-blind randomised study of efficacy and tolerance. Int J Clin Pharm Res. 2002;22(3):73-80.
5. Reti S. Ventolin to Salamol - a crossover study in New Zealand. N Z Med J. 2006;119(1244). http://www.nzma.org.nz/journal/119-1244/2276
6. Taylor R, Crane J, Kolbe J. Salamol and asthma in New Zealand [letter]. N Z Med J. 2006;119(1245). http://www.nzma.org.nz/journal/119-1245/ 2328
7. Yan K, Salome C, Woolcock AJ. Rapid method for measurement of bronchial responsiveness. Thorax 1983;38:760-5.
8. Hancox RJ, Haney S. Recovery from bronchoconstrictriction and bronchodilator tolerance. Clin Rev Aller Immuno. 2006;31(2-3):181-96
9. Hancox RJ, Aldridge RE, Cowan JO, et al. Tolerance to beta-agonists during acute bronchoconstriction. Eur Respir J. 1999;14:283-7.
10. Jones SL, Cowan JO, Flannery EM, et al. Reversing acute bronchoconstriction in asthma: The effect of bronchodilator tolerance after treatment with formoterol. Eur Respir J. 2001;17:368-73.
11. Wraight JM, Hancox RJ, Herbison GP, et al. Bronchodilator tolerance: The impact of increasing bronchoconstriction. Eur Respir J. 2003;21:810-5.
12. Haney S, Hancox RJ. Tolerance to bronchodilation during treatment with long-acting beta-agonists, a randomised controlled trial. Respiratory Research. 2005;6:107.
13. Asher I. Salamol and inequalities in New Zealand [editorial]. N Z Med J. 2006;119(1244). http://www.nzma.org.nz/journal/119-1244/2275
14. Medsafe. Hot topics. Medsafe Summary report. Salamol inhalers: New Zealand brand switching complaints investigation; 12 December 2005. http://www.medsafe.govt.nz/hot/papersreports/salamol.htm