-
2
-
-
34250156373
-
Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
-
This report provides greater detail on current understanding of the impact of superantigen on chronic rhinosinusitis
-
Bachert C, Zhang N, van Zele T, et al. Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis. Clin Allergy Immunol 2007; 20:163-175. This report provides greater detail on current understanding of the impact of superantigen on chronic rhinosinusitis.
-
(2007)
Clin Allergy Immunol
, vol.20
, pp. 163-175
-
-
Bachert, C.1
Zhang, N.2
van Zele, T.3
-
3
-
-
0035038554
-
Total and specific IgE in nasal polyps is related to local eosinophilic inflammation
-
Bachert C, Gevaert P, Holtappels G, et al. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 2001; 107:607-614.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 607-614
-
-
Bachert, C.1
Gevaert, P.2
Holtappels, G.3
-
4
-
-
20244382709
-
EAACI position paper on rhinosinusitis and nasal polyposis: Executive summary
-
Fokkens W, Lund V, Bachert C, et al. EAACI position paper on rhinosinusitis and nasal polyposis: executive summary. Allergy 2005; 60:583-601.
-
(2005)
Allergy
, vol.60
, pp. 583-601
-
-
Fokkens, W.1
Lund, V.2
Bachert, C.3
-
6
-
-
0031569468
-
Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia
-
Simon HU, Yousefi S, Schranz C, et al. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997; 158:3902-3908.
-
(1997)
J Immunol
, vol.158
, pp. 3902-3908
-
-
Simon, H.U.1
Yousefi, S.2
Schranz, C.3
-
7
-
-
0033764445
-
Nasal polyposis: From cytokines to growth
-
Bachert C, Gevaert P, Holtappels G, et al. Nasal polyposis: from cytokines to growth. Am J Rhinol 2000; 14:279-290.
-
(2000)
Am J Rhinol
, vol.14
, pp. 279-290
-
-
Bachert, C.1
Gevaert, P.2
Holtappels, G.3
-
8
-
-
33749046785
-
-
Van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006; 61:1280-1289. This report focuses on the possibility of differentiating between chronic sinus diseases based on cellular and cytokine pattern. An understanding of underlying T-effector cell bias is mandatory for an appreciation of the effects of S. aureus enterotoxins on the respective tissues.
-
Van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006; 61:1280-1289. This report focuses on the possibility of differentiating between chronic sinus diseases based on cellular and cytokine pattern. An understanding of underlying T-effector cell bias is mandatory for an appreciation of the effects of S. aureus enterotoxins on the respective tissues.
-
-
-
-
9
-
-
4944252186
-
Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
-
Van Zele T, Gevaert P, Watelet JB, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 2004; 114:981-983.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 981-983
-
-
Van Zele, T.1
Gevaert, P.2
Watelet, J.B.3
-
10
-
-
25144499173
-
Staphylococcal exotoxins and nasal polyposis: Analysis of systemic and local responses
-
Tripathi A, Kern R, Conley DB, et al. Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses. Am J Rhinol 2005; 19:327-333.
-
(2005)
Am J Rhinol
, vol.19
, pp. 327-333
-
-
Tripathi, A.1
Kern, R.2
Conley, D.B.3
-
11
-
-
38049109740
-
-
1. Furthermore, S. aureus derived protein A may directly induce mast cell degranulation, and thus contribute to the inflammation.
-
1. Furthermore, S. aureus derived protein A may directly induce mast cell degranulation, and thus contribute to the inflammation.
-
-
-
-
12
-
-
33644777428
-
-
Cardona ID, Goleva E, Ou LS, Leung DY. Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J Allergy Clin Immunol 2006; 117:688-695. Natural T-regulatory cells may also be impaired by S. aureus enterotoxins in their capability to suppress T-effector cells.
-
Cardona ID, Goleva E, Ou LS, Leung DY. Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J Allergy Clin Immunol 2006; 117:688-695. Natural T-regulatory cells may also be impaired by S. aureus enterotoxins in their capability to suppress T-effector cells.
-
-
-
-
13
-
-
0032948786
-
Staphylococcal toxins augment specific IgE responses by atopic patients exposed to allergen
-
Hofer MF, Harbeck RJ, Schlievert PM, Leung DY. Staphylococcal toxins augment specific IgE responses by atopic patients exposed to allergen. J Invest Dermatol 1999; 112:171-176.
-
(1999)
J Invest Dermatol
, vol.112
, pp. 171-176
-
-
Hofer, M.F.1
Harbeck, R.J.2
Schlievert, P.M.3
Leung, D.Y.4
-
14
-
-
0029838834
-
The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching
-
Jabara HH, Geha RS. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. Int Immunol 1996; 8:1503-1510.
-
(1996)
Int Immunol
, vol.8
, pp. 1503-1510
-
-
Jabara, H.H.1
Geha, R.S.2
-
15
-
-
0030469572
-
T helper cell-dependent, microbial superantigen mediated B cell activation in vivo
-
Tumang JR, Zhou JL, Gietl D, et al. T helper cell-dependent, microbial superantigen mediated B cell activation in vivo. Autoimmunity 1996; 24:247-255.
-
(1996)
Autoimmunity
, vol.24
, pp. 247-255
-
-
Tumang, J.R.1
Zhou, J.L.2
Gietl, D.3
-
16
-
-
0034744489
-
Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma
-
Ying S, Humbert M, Meng Q, et al. Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. J Allergy Clin Immunol 2001; 107:686-692.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 686-692
-
-
Ying, S.1
Humbert, M.2
Meng, Q.3
-
17
-
-
0034114471
-
Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients
-
Kleinjan A, Vinke JG, Severijnen LW, Fokkens WJ. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur Respir J 2000; 15:491-497.
-
(2000)
Eur Respir J
, vol.15
, pp. 491-497
-
-
Kleinjan, A.1
Vinke, J.G.2
Severijnen, L.W.3
Fokkens, W.J.4
-
18
-
-
0242494188
-
Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
-
Coker HA, Durham SR, Gould HJ. Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients. J Immunol 2003; 171:5602-5610.
-
(2003)
J Immunol
, vol.171
, pp. 5602-5610
-
-
Coker, H.A.1
Durham, S.R.2
Gould, H.J.3
-
19
-
-
37549027665
-
-
Van Zele T, Gevaert P, Holtappels G, et al. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 2007 [Epub ahead of print]. The impact of staphylococcal superantigens on T cells in polyp tissue is well described; here we extend findings on the B-cell linage and demonstrate a shift in immunoglobulin production.
-
Van Zele T, Gevaert P, Holtappels G, et al. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 2007 [Epub ahead of print]. The impact of staphylococcal superantigens on T cells in polyp tissue is well described; here we extend findings on the B-cell linage and demonstrate a shift in immunoglobulin production.
-
-
-
-
20
-
-
0028315869
-
Nasal polyps: Effects of seasonal allergen exposure
-
Keith PK, Conway M, Evans S, et al. Nasal polyps: effects of seasonal allergen exposure. J Allergy Clin Immunol 1994; 93:567-574.
-
(1994)
J Allergy Clin Immunol
, vol.93
, pp. 567-574
-
-
Keith, P.K.1
Conway, M.2
Evans, S.3
-
21
-
-
0027200566
-
Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens
-
Leung DY, Harbeck R, Bina P, et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest 1993; 92:1374-1380.
-
(1993)
J Clin Invest
, vol.92
, pp. 1374-1380
-
-
Leung, D.Y.1
Harbeck, R.2
Bina, P.3
-
22
-
-
20444455762
-
Prostaglandin, leukotriene and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis
-
Perez-Novo CA, Van Cauwenberge P, Bachert C. Prostaglandin, leukotriene and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 2005; 115:1189-1196.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 1189-1196
-
-
Perez-Novo, C.A.1
Van Cauwenberge, P.2
Bachert, C.3
-
23
-
-
20444464066
-
Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer
-
Sherven Sharma, Seok-Chul Yang, Li Zhu, et al. Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Cancer Res 2005; 65:5211-5220.
-
(2005)
Cancer Res
, vol.65
, pp. 5211-5220
-
-
Sharma, S.1
Yang, S.2
Zhu, L.3
-
24
-
-
33748678132
-
-
Perez-Novo CA, Claeys C, van Zele T, et al. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. Am J Rhinol 2006; 20:456-460. It is suggested that there might be a link between aspirin sensitivity and IgE formation in response to enterotoxins. Here, changes in the arachidonic acid metabolism related to enterotoxin-specific IgE in polyps are discussed.
-
Perez-Novo CA, Claeys C, van Zele T, et al. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. Am J Rhinol 2006; 20:456-460. It is suggested that there might be a link between aspirin sensitivity and IgE formation in response to enterotoxins. Here, changes in the arachidonic acid metabolism related to enterotoxin-specific IgE in polyps are discussed.
-
-
-
-
26
-
-
34249740696
-
-
Bachert C, Gevaert P, Zhang N, et al. Role of staphylococcal superantigens in airway disease. Chem Immunol Allergy 2007; 93:214-236. S. aureus enterotoxins not only affect the upper but also the lower airways! Current knowledge on the role of superantigens in rhinitis, asthma, chronic obstructive pulmonary disease and early childhood wheezing is reviewed.
-
Bachert C, Gevaert P, Zhang N, et al. Role of staphylococcal superantigens in airway disease. Chem Immunol Allergy 2007; 93:214-236. S. aureus enterotoxins not only affect the upper but also the lower airways! Current knowledge on the role of superantigens in rhinitis, asthma, chronic obstructive pulmonary disease and early childhood wheezing is reviewed.
-
-
-
-
27
-
-
0034048372
-
-
Hauk PJ, Hamid QA, Chrousos GP, Leung DY. Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens. J Allergy Clin Immunol 2000; 105:782-787.
-
Hauk PJ, Hamid QA, Chrousos GP, Leung DY. Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens. J Allergy Clin Immunol 2000; 105:782-787.
-
-
-
-
28
-
-
0036062279
-
Staphylococcus aureus: Colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis
-
Breuer K, Häussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 2002; 147:55-61.
-
(2002)
Br J Dermatol
, vol.147
, pp. 55-61
-
-
Breuer, K.1
Häussler, S.2
Kapp, A.3
Werfel, T.4
-
29
-
-
34250000045
-
-
Rebecca A, Buonpane1, Hywyn R, et al. Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med 2007; 13: 725-729. The authors have constructed compounds to antagonize SEB, which is a therapeutic principle of possible relevance for proof-of-concept studies in acute exposure scenarios.
-
Rebecca A, Buonpane1, Hywyn R, et al. Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med 2007; 13: 725-729. The authors have constructed compounds to antagonize SEB, which is a therapeutic principle of possible relevance for proof-of-concept studies in acute exposure scenarios.
-
-
-
-
30
-
-
33750508779
-
-
Gevaert P, Lang-Loidolt D, Stammberger H, et al. Nasal Interleukin-5 levels determine the response to antiinterleukin-5 treatment in nasal polyp patients. J Allergy Clin Immunol 2006; 118:1133-1141. This is the first single-shot study using a humanized anti-IL-5 monoclonal antibody to treat nasal polyposis, showing a promising effect in a predictable subpopulation of patients. The study formed the basis for a currently running trial with repeated injections of anti-IL-5, which is showing superior clinical efficacy.
-
Gevaert P, Lang-Loidolt D, Stammberger H, et al. Nasal Interleukin-5 levels determine the response to antiinterleukin-5 treatment in nasal polyp patients. J Allergy Clin Immunol 2006; 118:1133-1141. This is the first single-shot study using a humanized anti-IL-5 monoclonal antibody to treat nasal polyposis, showing a promising effect in a predictable subpopulation of patients. The study formed the basis for a currently running trial with repeated injections of anti-IL-5, which is showing superior clinical efficacy.
-
-
-
|