"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells

Journal of Neuroscience Research

Volumn 86, Issue 1, 2008, Pages 118-124

  Young, Jennifer J ^a   Mehdi, Amna ^a   Stohl, Lori L ^a   Levin, Lonny R ^a   Buck, Jochen ^a   Wagner, John A ^a   Stessin, Alexander M ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Adenylyl cyclase; Compartmentalization; Nerve growth factor; Neuron; Protein kinase C

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; NERVE GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADENYLATE CYCLASE; ANIMALS; CELL MOVEMENT; CYCLIC AMP; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; NERVE GROWTH FACTOR; PC12 CELLS; PHORBOL ESTERS; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 38049095842     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21458     Document Type: Article

References (30)

1. Altun-Gultekin ZA. 1997. Signal transduction mechanisms and the role of cytoskeleton in PC12 migration: regulation by SRC, RAS, and RAC. New York: Cornell University Press. 172 p.
2. Bhargava S. 2007. Role of nerve growth factor and its receptor in the morphogenesis of neural tube in early chick embryo. Gen Comp Endocrinol (in press).
3. Bornfeldt KE. 2006. A single second messenger: several possible cellular responses depending on distinct subcellular pools. Circ Res 99:790-792.
4. Bundey RA, Insel PA. 2004. Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Sci STKE 2004(231):pe19.
5. Chao MV. 1994. The p75 neurotrophin receptor. J Neurobiol 25:1373-1385.
6. Chao MV, Rajagopal R, Lee FS. 2006. Neurotrophin signalling in health and disease. Clin Sci 110:167-173.
7. Choe Y, Jung H, Khang I, Kim K. 2003. Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. J Neuroendocrinol 15:508-515.
8. Choi EJ, Wong ST, Dittman AH, Storm DR. 1993. Phorbol ester stimulation of the type I and type III adenylyl cyclases in whole cells. Biochemistry 32:1891-1894.
9. Gallagher HC, Odumeru OA, Regan CM. 2000. Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. J Neurosci Res 61:636-645.
10. Glowacka D, Wagner JA. 1990. Role of the cAMP-dependent protein kinase and protein kinase C in regulating the morphological differentiation of PC12 cells. J Neurosci Res 25:453-462.
11. Glowacka D, Ginty DD, Wagner JA. 1992. Synergistic effects of nerve growth factor and phorbol 12-myristate 13-acetate on rapid motility and process formation in PC12 cells: the role of laminin. J Neurosci Res 31:263-272.
12. Greene LA, Tischler AS. 1982. PC12 pheochromocytoma cultures in neurobiological research. Adv Cell Neurobiol 3:373-414.
13. Han H, Stessin AM, Roberts J, Hess KC, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C. 2005. Role of calcium-sensing soluble adenylyl cyclase in TNF signal transduction in human neutrophils. J Exp Med 202:353-361.
14. Jacobowitz O, Iyengar R. 1994. Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc Natl Acad Sci U S A 91:10630-10634.
15. s-stimulated adenylyl cyclases by phorbol ester treatment. J Biol Chem 268:3829-3832.
16. Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y. 1994. Differential activation of adenylyl cyclase by protein kinase C isoenzymes [published erratum appears in J Biol Chem 1994 Sep 9;269:22912]. J Biol Chem 269:16554-16558.
17. Kawabe J, Ebina T, Toya Y, Oka N, Schwencke C, Duzic E, Ishikawa Y. 1996. Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells. FEBS Lett 384:273-276.
18. Kobayashi E, Nakano H, Morimoto M, Tamaoki T. 1989. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
19. Levi-Montalcini R, Angeletti PU. 1968. Nerve growth factor. Physiol Rev 48:534-569.
20. McKenna JP, Hanson PJ. 1993. Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells. Biochem Pharmacol 46:583-588.
21. Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. 2004. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res 95:67-75.
22. Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M. 2006. Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res 98:226-234.
23. Morimoto BH, Koshland D Jr. 1994. Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells. J Biol Chem 269:4065-4069.
24. Stessin AM, Zippin JH, Kamenetsky M, Hess KC, Buck J, Levin LR. 2006. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem 281:17253-17258.
25. Vaudry D, Stork PJ, Lazarovici P, Eiden LE. 2002. Signaling pathways for PC12 cell differentiation: making the right connections. Science 296:1648-1649.
26. Wu KY, Zippin JH, Huron DR, Kamenetsky M, Hengst U, Buck J, Levin LR, Jaffrey SR. 2006. Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci 9:1257-1264.
27. Yoshimura M, Cooper DMF. 1993. Type-specific stimulation of adenylylcyclase by protein kinase C. J Biol Chem 268:4604-4607.
28. Zaccolo M, Pozzan T. 2002. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295:1711-1715.
29. Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J. 2003. Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J 17:82-84.
30. Zippin JH, Farrell J, Huron D, Kamenetsky M, Hess KC, Fischman DA, Levin LR, Buck J. 2004. Bicarbonate-responsive "solubleadenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol 164:527-534.