Liquid chromatography/electrospray ionization mass spectrometry method for the determination of the active metabolite M-1 of suplatast tosilate in human plasma

Biomedical Chromatography

Volumn 21, Issue 12, 2007, Pages 1297-1302

  Ding, Li ^a   Ding, Likun ^a   Zhou, Xia ^a   Yang, Lin ^b   Wen, Aidong ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

4 (3 ethoxy 2 hydroxypropoxy) acrylanilide; LC ESIMS; Pharmacokinetics; Suplatast tosilate

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN);

4-(3-ETHOXY-2-HYDROXYPROPOXY) ACRYLANILIDE; ACTIVE METABOLITES; AMMONIUM ACETATE; DIETHYL ETHERS; HUMAN PLASMAS; LC/ESI-MS; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; MOBILE PHASIS; PLASMA SAMPLES; SUPLATAST TOSILATE;

PHARMACOKINETICS;

DRUG METABOLITE; SUPLATAST TOSYLATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 38049082930     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.894     Document Type: Article

References (7)

1. CDER. Guidance for Industry, Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, May 2001.
2. 14C-suplatast tosilate(TPD-1151T) to rats. Drug Metabolism and pharmacokinetics 1992; 7: 399.
3. Meng F, Chen XY, Zeng YL and Zhong DF. Sensitive liquid chromatography-tandem mass spectrometry, method for the determination of cefixime in human plasma: application to a pharma-cokinetics study. Journal of Chromatography A 2005; 819: 277.
4. Satoh T, Sasaki G, Wu MH, Yokozeki H, Katayama I and Nishioka K. Suplatast tosilate inhibits ensinophil production and recruitment into the skin in murine contact sensitivity. Clinical Immunology 2003; 108: 257.
5. Taniguchi H, Togawa M, Ohwata K, Kiniwa M, Matsuura N, Nagai H and Koda A. Suplatast tosilate, a new type of antiallergic agent, prevents the expression of airway hyperresponsiveness in guinea pigs. Journal of European Pharmacology 1996; 318: 447.
6. Tei M, Kodama K, Yafune A, Muranushi A, Takayanagi H, Takebe M, Shindoh T, Masuda H, Kuwata K, Matsushima E, Muramoto K and Umeno Y. Pharmacokinetics of suplatast tosilate (TPD-1151T) in man after oral administration. Clinical Report 1992; 26: 3199.
7. Ushio T and Yamamoto K. High-performance liquid chromatoghraphy of enantiomers {2-(4-(3-ethoxy-2-hydroxypropoxy) phenylcarbamoyl) ethyl} dimethylsulforium p-toluenesulfonate (suplatast tosilate) on a cellulose tris-3,5-dimethyphenylcarbamate column. Journal of Chromatography A 1994; 684: 235.