Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 78, Issue 1, 2008, Pages 3-10

  Terry, K K ^a   Lebel, W S ^a   Riccardi, K A ^a   Grasser, W A ^a   Thompson, D D ^a   Paralkar, V M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[3 [[(4 TERT BUTYLBENZYL)(3 PYRIDINESULFONYL)AMINO]METHYL]PHENOXY]ACETIC ACID; ACETYLCHOLINE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; MISOPROSTOL; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; SULPROSTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; GUINEA PIG; IN VITRO STUDY; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; UTERUS CONTRACTION;

ANIMALS; DINOPROSTONE; FEMALE; GESTATIONAL AGE; GUINEA PIGS; MYOMETRIUM; OXYTOCICS; PREGNANCY; PYRIDINES; RECEPTORS, PROSTAGLANDIN E; UTERINE CONTRACTION; UTERUS;

CAVIA;

EID: 38049081621     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2007.10.003     Document Type: Article

References (32)

1. Kennedy I., Coleman R.A., Humphrey P.P.A., Levy G.P., and Lumley P. Studies on the characterisation of prostanoid receptors: a proposed classification. Prostaglandins 24 (1982) 667-689
2. Coleman R.A., Smith W.L., and Narumiya S. International union of pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 (1994) 205-229
3. Coleman R.A. Prostanoid Receptors (1998), The IUPHAR Receptor Compendium pp. 230-244
4. Negishi M., Sugimoto Y., and Ichikawa A. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim. Biophys. Acta 1259 (1995) 109-120
5. Sugimoto Y., Narumiya S., and Ichikawa A. Distribution and function of prostanoid receptors: studies from kockout mice. Prog. Lipid. Res. 39 (2000) 289-314
6. Breyer R.M., Kennedy C.R.J., Zhang Y., and Breyer M.D. Structure-function analyses of eicosanoid receptors. Ann. N.Y. Acad. Sci. 905 (2000) 221-231
7. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 661-690
8. Novy M.J., and Liggins G.C. Role of prostaglandins, prostacyclin, and thromboxanes in the physiologic control of the uterus and in parturition. Sem. Perinatol. 4 (1980) 45-66
9. Brodt-Eppley J., and Myatt L. Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet. Gynecol. 93 (1999) 89-93
10. Bernal A.L. Mechanisms of labour-biochemical aspects. BJOG: Int. J. Obstet. Gynaecol. 110 Suppl. 20 (2003) 39-45
11. Mahajan D.K., and London S.N. Mifepristone (RU486): a review. Fertil. Steril. 68 (1997) 967-976
12. Carbillon L., Seince N., and Uzan M. Myometrial maturation and labour. Ann. Med. 33 (2001) 571-578
13. Törnblom S.A., Östlund E., Granström L., and Ekman G. Pre-term cervical ripening and labor induction. Eur. J. Obstet. Gynecol. 104 (2002) 120-123
14. Keirse M.J.N.C. Natural prostaglandins for induction of labor and preinduction cervical ripening. Clin. Obstet. Gynecol. 49 (2006) 609-626
15. 2 receptor protein expression in ovine cervix. Reproduction 131 (2006) 743-750
16. Senior J., Marshall K., Sangha R., Baxter G.S., and Clayton J.K. In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometrium. Br. J. Pharmacol. 102 (1991) 747-753
17. Senior J., Sangha R., Baxter G.S., Marshall K., and Clayton J.K. In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium. Br. J. Pharmacol. 107 (1992) 215-221
18. Senior J., Marshall K., Sangha R., and Clayton J.K. In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br. J. Pharmacol. 108 (1993) 501-506
19. 2 synthase-2 expression in ovine intrauterine tissues during the course of labor. Biol. Reprod. 62 (2000) 797-805
20. Smith G.C.S., Wu W.X., and Nathanielsz P.W. Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus. Biol. Reprod. 64 (2001) 1131-1137
21. 2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy. Endocrinology 144 (2003) 3076-3091
22. 2 receptor subtype EP-2 is not involved in the induction of non-pregnant guinea pig uterine contractions associated with terminal pregnancy. Prostaglandins Leukot. Essent. Fatty Acids 71 (2004) 399-404
23. Brodt-Eppley J., and Myatt L. Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum. Biol. Reprod. 59 (1998) 878-883
24. Dong Y.L., and Yallampalli C. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP2 and contractile FP receptors in the rat uterus. Biol. Reprod. 62 (2000) 533-539
25. 2 prostanoid receptor subtypes. Eur. J. Pharmacol. 340 (1997) 227-241
26. Paralkar V.M., Borovecki F., Ke H.Z., et al. An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. PNAS 100 (2003) 6736-6740
27. Institute of Laboratory Animal Resources, National Research Council. Guide for the Care and Use of Animals (1996), National Academy Press, Washington, DC
28. Bedford C.A., Challis J.R.G., Harrison F.A., and Heap R.B. The role of oestrogens and progesterone in the onset of parturition in various species. J. Reprod. Fertil. Suppl. 16 (1972) 1-23
29. Wagner J.E., and Manning P.J. Biology of the Guinea Pig (1976), Academic Press, New York p. 83
30. Grigsby P.L., Sooranna S.R., Adu-Amankwa B., et al. Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Biol. Reprod. 75 (2006) 297-305
31. Coleman H.A., Hart J.D.E., Tonta M.A., and Parkington H.C. Changes in the mechanisms involved in uterine contractions during pregnancy in guinea-pigs. J. Physiol. 523 3 (2000) 785-798
32. 2+ in pregnant rat myometrium. Am. J. Obstet. Gynecol. 175 (1996) 199-206