Behavioral analysis of chronic exposure to diphenylarsinic acid associated with influence on central nervous systems

Japanese Journal of Neuropsychopharmacology

Volumn 27, Issue 5-6, 2007, Pages 181-189

  Miyagawa, Kazuya ^a   Narita, Minoru ^a   Miyatake, Mayumi ^a   Kato, Koichi ^b   Yamanaka, Kenzo ^b   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Anxiety; Apoptosis; Diphenylarsinic acid; Mice; Motor impairment

Indexed keywords

ARSINIC ACID DERIVATIVE; CASPASE 3; DIPHENYLARSINIC ACID; DOPAMINE RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MYELIN ASSOCIATED GLYCOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; BIOASSAY; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CEREBELLUM DISEASE; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; ENCEPHALOMALACIA; ENZYME ACTIVATION; GLIA CELL; IMMUNOREACTIVITY; IN VIVO STUDY; LEARNING DISORDER; LONG TERM EXPOSURE; MAZE TEST; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NEUROTOXICITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; RECEPTOR DOWN REGULATION;

ANIMALS; ANXIETY DISORDERS; ARSENIC POISONING; ARSENICALS; CASPASE 3; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FEMALE; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; MOVEMENT DISORDERS; NEUROGLIA; PREGNANCY; PSYCHOMOTOR DISORDERS; WATER POLLUTANTS, CHEMICAL;

EID: 38049055214     PISSN: 13402544     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Hollmann, M. and Heinemann, S. (1994) Cloned glutamate receptors. Annu Rev Neurosci, 17: 31-108.
2. Ishii, K., Tamaoka, A., Otsuka, F., Iwasaki, N., Shin, K., Matsui, A., Endo, G., Kumagai, Y., Ishii, T., Shoji, S., Ogata, T., Ishizaki, M., Doi, M. and Shimojo, N. (2004) Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan. Ann Neurol, 56: 741-745.
3. Kaneko, S., Hikida, T., Watanabe, D., Ichinose, H., Nagatsu, T., Kreitman, R. J., Pastan, I. and Nakanishi, S. (2000) Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science, 289: 633-637.
4. Kinoshita, K., Ochi, T., Suzuki, T., Kita, K. and Kaise, T. (2006) Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid. Toxicology, 225: 142-149.
5. Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., Nagatsu, I., Fujita, K., Kreitman, R. J., Pastan, I. and Nagatsu, T. (1995) Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice. Proc Natl Acad Sci USA, 92: 1132-1136.
6. Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E. C., Otto, A. and Pfrieger, F. W. (2001) CNS synaptogenesis promoted by glial-derived cholesterol. Science, 294: 1354-1357.
7. Nägler, K., Mauch, D. H. and Pfrieger, F. W. (2001) Glia-derived signals induce synapse formation in neurons of the rat central nervous system. J Physiol, 533: 665-679.
8. Ochi, T., Kinoshita, K., Suzuki, T., Miyazaki, K., Noguchi, A. and Kaise, T. (2006) The role of glutathione on the cytotoxic effects and cellular uptake of diphenylarsinic acid, a degradation product of chemical warfare agents. Arch Toxicol, 80: 486-491
9. Okazaki, M., Sakaue, M., Kunimoto, S., Morita, M. and Kunimoto, M. (2003) Assessment of potential neurotoxic actions of organoarsenic compounds using human neuroblastoma NB-1 cells and rat cerebellar neurons in primary culture. J Health Sci, 49: 410-415.
10. Saunders, N. R. and Mollgard, K. (1984) Development of the blood-brain barrier. J Dev Physiol, 6: 45-57.
11. Temple, S. (2001) The development of neural stem cells. Nature, 414: 112-117.
12. Ullian, E. M., Sapperstein, S. K., Christopherson, K. S. and Barres, B. A. (2001) Control of synapse number by glia. Science, 291: 657-Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R. J., Pastan, I. and Nakanishi, S. (1998) Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell, 95: 17-27.