Induction of hepatic cytochrome P4501A1/2B activity and disruption of thyroglobulin synthesis/secretion by mono-ortho polychlorinated biphenyl and its hydroxylated metabolites in rat cell lines

Environmental Toxicology and Chemistry

Volumn 27, Issue 1, 2008, Pages 220-225

  Yang, Fangxing ^a   Xu, Ying ^a   Pan, Hongmei ^b   Wu, Desheng ^b  

^a INSTITUTE OF HYDROBIOLOGY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

7 Ethoxyresorufin O deethylase; 7 Pentoxyresorufin O dealkylase; Hydroxylated polychlorinated biphenyl; Mono ortho polychlorinated biphenyl; Thyroglobulin

Indexed keywords

7-ETHOXYRESORUFIN-O-DEETHYLASE; 7-PENTOXYRESORUFIN-O-DEALKYLASE; HYDROXYLATED POLYCHLORINATED BIPHENYL; MONO-ORTHO POLYCHLORINATED BIPHENYL; THYROGLOBULIN;

CELLS; HYDROXYLATION; METABOLITES; POLYCHLORINATED BIPHENYLS; RATS;

HORMONES;

4' POLYCHLORINATED BIPHENYL 121; 4' POLYCHLORINATED BIPHENYL 159; 4' POLYCHLORINATED BIPHENYL 172; CYTOCHROME P450 1A1; CYTOCHROME P450 2B; ETHOXYRESORUFIN DEETHYLASE; MONO 2 POLYCHLORINATED BIPHENYL 156; PENTOXYRESORUFIN DEALKYLASE; POLYCHLORINATED BIPHENYL DERIVATIVE; THYROGLOBULIN; UNCLASSIFIED DRUG;

CELL ORGANELLE; CYTOCHROME; IMMUNOASSAY; METABOLITE; PCB; POLLUTION EFFECT; RODENT; TOXICITY;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; RADIOIMMUNOASSAY; RAT; THYROID FOLLICLE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; HYDROXYLATION; LIVER; METABOLISM; POLYCHLORINATED BIPHENYLS; RATS; THYROGLOBULIN;

RATTUS;

EID: 38049041368     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/07-108.1     Document Type: Article

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