Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels

FEBS Letters

Volumn 582, Issue 2, 2008, Pages 165-170

  Iovine, M Kathryn ^a   Gumpert, Anna M ^a   Falk, Matthias M ^a   Mendelson, Tamra C ^b  

^a LEHIGH UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Connexin; Cx23; Gap junction; Pannexin; Zebrafish

Indexed keywords

CONNEXIN 23; CONNEXIN 4; CYSTEINE; GAP JUNCTION PROTEIN; INNEXIN; ISOPROTEIN; PANNEXIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; GAP JUNCTION; GENETIC CONSERVATION; GENOME; HUMAN; HUMAN CELL; MAMMAL; MEMBRANE BIOLOGY; MEMBRANE CHANNEL; MOLECULAR PHYLOGENY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEOMICS; SEQUENCE HOMOLOGY; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CONNEXINS; CYSTEINE; DNA PRIMERS; GAP JUNCTIONS; HELA CELLS; HUMANS; IN SITU HYBRIDIZATION; LENS, CRYSTALLINE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; ZEBRAFISH;

DANIO RERIO; MAMMALIA;

EID: 38049036928     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.11.079     Document Type: Article

References (21)

1. Sohl G., and Willecke K. Gap junctions and the connexin protein family. Cardiovasc. Res. 62 (2004) 228-232
2. White T.W., Wang H., Mui R., Litteral J., and Brink P.R. Cloning and functional expression of invertebrate connexins from Halocynthia pyriformis. FEBS Lett. 577 (2004) 42-48
3. Panchin Y., Kelmanson I., Matz M., Lukyanov K., Usman N., and Lukyanov S. A ubiquitous family of putative gap junction molecules. Curr. Biol. 10 (2000) R473-R474
4. Baranova A., et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 83 (2004) 706-716
5. Yen M.R., and Saier Jr. M.H. Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog. Biophys. Mol. Biol. 94 (2007) 5-14
6. Phelan P. Innexins: members of an evolutionarily conserved family of gap-junction proteins. Biochim. Biophys. Acta 1711 (2005) 225-245
7. Alexopoulos H., et al. Evolution of gap junctions: the missing link?. Curr. Biol. 14 (2004) R879-R880
8. Kumar N.M., and Gilula N.B. Molecular biology and genetics of gap junction channels. Semin. Cell Biol. 3 (1992) 3-16
9. Panchin Y.V. Evolution of gap junction proteins-the pannexin alternative. J. Exp. Biol. 208 (2005) 1415-1419
10. Foote C.I., Zhou L., Zhu X., and Nicholson B.J. The pattern of disulfide linkages in the extracellular loop regions of connexin 32 suggests a model for the docking interface of gap junctions. J. Cell Biol. 140 (1998) 1187-1197
11. Eastman S.D., Chen T.H., Falk M.M., Mendelson T.C., and Iovine M.K. Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics 87 (2006) 265-274
12. *, Phylogenetic Analysis Using Parsimony (* and other methods). Sinauer Associates, Sunderland, MA.
13. Felsenstein, J. (2007) PHYLIP-Phylogeny Inference Package (Version 3.67). Available from: .
14. Li H., Liu T.F., Lazrak A., Peracchia C., Goldberg G.S., Lampe P.D., and Johnson R.G. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J. Cell Biol. 134 (1996) 1019-1030
15. Hoptak-Solga A.D., Klein K.A., Derosa A.M., White T.W., and Iovine M.K. Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communication. FEBS Lett. 581 (2007) 3297-3302
16. Contreras J.E., Saez J.C., Bukauskas F.F., and Bennett M.V. Gating and regulation of connexin 43 (Cx43) hemichannels. Proc. Natl. Acad. Sci. USA 100 (2003) 11388-11393
17. Pfahnl A., and Dahl G. Gating of cx46 gap junction hemichannels by calcium and voltage. Pflugers Arch. 437 (1999) 345-353
18. Quist A.P., Rhee S.K., Lin H., and Lal R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 148 (2000) 1063-1074
19. Thimm J., Mechler A., Lin H., Rhee S., and Lal R. Calcium-dependent open/closed conformations and interfacial energy maps of reconstituted hemichannels. J. Biol. Chem. 280 (2005) 10646-10654
20. Trexler E.B., Bennett M.V., Bargiello T.A., and Verselis V.K. Voltage gating and permeation in a gap junction hemichannel. Proc. Natl. Acad. Sci. USA 93 (1996) 5836-5841
21. Bao L., Sachs F., and Dahl G. Connexins are mechanosensitive. Am. J. Physiol. Cell Physiol. 287 (2004) C1389-C1395